Motif ID: Lhx8

Z-value: 0.815


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.195.2e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_66227573 5.152 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr13_-_66851513 2.992 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr13_-_66852017 2.833 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr10_-_67912620 1.646 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr7_+_91090728 1.625 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090697 1.614 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr13_+_65512678 1.439 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr4_-_136898803 1.170 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr6_-_136173492 1.008 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr13_+_5861489 0.837 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr18_+_23415400 0.790 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr11_+_16257706 0.782 ENSMUST00000109645.2
ENSMUST00000109647.2
 Vstm2a

V-set and transmembrane domain containing 2A

chr9_-_124493793 0.767 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr6_+_15185203 0.756 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr2_-_72986716 0.731 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr3_-_116712696 0.726 ENSMUST00000169530.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr17_-_90088343 0.689 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr3_-_73056943 0.643 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr5_-_76905390 0.621 ENSMUST00000135954.1
 Aasdh
aminoadipate-semialdehyde dehydrogenase
chr4_-_155645408 0.572 ENSMUST00000115821.2
 Gm10563
predicted gene 10563

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.5 1.6 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.3 1.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 1.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.0 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 0.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.2 0.7 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.2 0.5 GO:0045204 MAPK export from nucleus(GO:0045204)
0.2 0.5 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.0 0.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.5 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.4 GO:0031280 negative regulation of cyclase activity(GO:0031280)
0.1 0.3 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.3 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.3 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.1 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000343)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.5 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 1.0 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.2 0.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.7 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.0 0.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.3 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.1 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)