Motif ID: Lhx8

Z-value: 0.815


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.195.2e-01Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_66227573 5.152 ENSMUST00000167981.2
 Gm10772
predicted gene 10772
chr13_-_66851513 2.992 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr13_-_66852017 2.833 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr10_-_67912620 1.646 ENSMUST00000064656.7
 Zfp365
zinc finger protein 365
chr7_+_91090728 1.625 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090697 1.614 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr13_+_65512678 1.439 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr4_-_136898803 1.170 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr6_-_136173492 1.008 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr13_+_5861489 0.837 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr18_+_23415400 0.790 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr11_+_16257706 0.782 ENSMUST00000109645.2
ENSMUST00000109647.2
 Vstm2a

V-set and transmembrane domain containing 2A

chr9_-_124493793 0.767 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr6_+_15185203 0.756 ENSMUST00000154448.1
 Foxp2
forkhead box P2
chr2_-_72986716 0.731 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr3_-_116712696 0.726 ENSMUST00000169530.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr17_-_90088343 0.689 ENSMUST00000173917.1
 Nrxn1
neurexin I
chr3_-_73056943 0.643 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr5_-_76905390 0.621 ENSMUST00000135954.1
 Aasdh
aminoadipate-semialdehyde dehydrogenase
chr4_-_155645408 0.572 ENSMUST00000115821.2
 Gm10563
predicted gene 10563
chr5_-_139129662 0.546 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr3_-_116712644 0.531 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr12_+_4082596 0.530 ENSMUST00000049584.5
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr4_-_129121889 0.478 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
 Hpca


hippocalcin


chr5_-_62765618 0.440 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_-_59210881 0.439 ENSMUST00000040622.1
 P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr11_+_26387194 0.407 ENSMUST00000109509.1
ENSMUST00000136830.1
 Fancl

Fanconi anemia, complementation group L

chr12_+_38783455 0.396 ENSMUST00000161980.1
ENSMUST00000160701.1
 Etv1

ets variant gene 1

chr10_-_4432285 0.373 ENSMUST00000155172.1
 Rmnd1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr12_-_20900867 0.371 ENSMUST00000079237.5
 Zfp125
zinc finger protein 125
chr17_-_31519914 0.345 ENSMUST00000167419.1
ENSMUST00000171291.1
 Wdr4

WD repeat domain 4

chr19_-_24961545 0.344 ENSMUST00000025815.8
 Cbwd1
COBW domain containing 1
chr2_+_65620829 0.333 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr15_+_21111452 0.324 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr19_-_11336107 0.313 ENSMUST00000056035.2
ENSMUST00000067532.4
 Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr11_+_110968016 0.292 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr8_+_110079758 0.289 ENSMUST00000058804.8
 Zfp612
zinc finger protein 612
chr2_-_114013619 0.278 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr3_-_53017195 0.275 ENSMUST00000036665.4
 Cog6
component of oligomeric golgi complex 6
chr8_-_57652993 0.267 ENSMUST00000110316.2
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr10_-_19907545 0.264 ENSMUST00000134220.1
 Pex7
peroxisomal biogenesis factor 7
chr19_-_4042165 0.263 ENSMUST00000042700.9
 Gstp2
glutathione S-transferase, pi 2
chr16_-_16829276 0.250 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr8_-_69373383 0.248 ENSMUST00000072427.4
 Gm10033
predicted gene 10033
chr4_+_126556994 0.242 ENSMUST00000147675.1
 Clspn
claspin
chr2_-_45110336 0.230 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr9_+_44334685 0.221 ENSMUST00000052686.2
 H2afx
H2A histone family, member X
chr3_+_106113229 0.201 ENSMUST00000079132.5
ENSMUST00000139086.1
 Chia

chitinase, acidic

chr4_-_62502233 0.191 ENSMUST00000037820.2
 Hdhd3
haloacid dehalogenase-like hydrolase domain containing 3
chr13_-_62466709 0.191 ENSMUST00000076195.5
 Zfp935
zinc finger protein 935
chr18_-_43687695 0.191 ENSMUST00000082254.6
 Jakmip2
janus kinase and microtubule interacting protein 2
chr2_+_21205719 0.176 ENSMUST00000054591.3
ENSMUST00000102952.1
ENSMUST00000138965.1
ENSMUST00000138914.1
ENSMUST00000102951.1
 Thnsl1




threonine synthase-like 1 (bacterial)




chr7_-_19359477 0.160 ENSMUST00000047036.8
 Cd3eap
CD3E antigen, epsilon polypeptide associated protein
chr3_+_107291215 0.157 ENSMUST00000029502.7
 Slc16a4
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr3_-_100685431 0.140 ENSMUST00000008907.7
 Man1a2
mannosidase, alpha, class 1A, member 2
chr1_+_33908172 0.137 ENSMUST00000182513.1
ENSMUST00000183034.1
 Dst

dystonin

chr2_-_119662756 0.135 ENSMUST00000028768.1
ENSMUST00000110801.1
ENSMUST00000110802.1
 Ndufaf1


NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1


chr8_-_57653023 0.132 ENSMUST00000034021.5
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr18_-_31911903 0.126 ENSMUST00000054984.6
 Sft2d3
SFT2 domain containing 3
chr1_-_170867761 0.122 ENSMUST00000027974.6
 Atf6
activating transcription factor 6
chr8_-_41054771 0.121 ENSMUST00000093534.4
 Mtus1
mitochondrial tumor suppressor 1
chr2_-_52558539 0.118 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr12_+_38783503 0.117 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr1_-_72284248 0.115 ENSMUST00000097698.4
ENSMUST00000027381.6
 Pecr

peroxisomal trans-2-enoyl-CoA reductase

chr2_-_114175321 0.110 ENSMUST00000043160.6
 Aqr
aquarius
chr5_-_98566762 0.108 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr5_-_76905463 0.101 ENSMUST00000146570.1
ENSMUST00000142450.1
ENSMUST00000120963.1
 Aasdh


aminoadipate-semialdehyde dehydrogenase


chr18_+_37341702 0.097 ENSMUST00000053037.3
 Pcdhb7
protocadherin beta 7
chr10_-_4432312 0.095 ENSMUST00000126102.1
ENSMUST00000131853.1
ENSMUST00000042251.4
 Rmnd1


required for meiotic nuclear division 1 homolog (S. cerevisiae)


chr1_-_45890078 0.092 ENSMUST00000183590.1
 Gm5269
predicted gene 5269
chr15_+_78935177 0.089 ENSMUST00000145157.1
ENSMUST00000123013.1
 Nol12

nucleolar protein 12

chr1_+_17145357 0.086 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chr11_+_98798653 0.085 ENSMUST00000037930.6
 Msl1
male-specific lethal 1 homolog (Drosophila)
chr15_-_83595111 0.085 ENSMUST00000016901.3
 Ttll12
tubulin tyrosine ligase-like family, member 12
chr11_+_110968056 0.072 ENSMUST00000125692.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr7_+_88430257 0.069 ENSMUST00000107256.2
 Rab38
RAB38, member of RAS oncogene family
chr3_+_54361103 0.063 ENSMUST00000107985.3
ENSMUST00000117373.1
ENSMUST00000073012.6
ENSMUST00000081564.6
 Postn



periostin, osteoblast specific factor



chr10_+_58497918 0.063 ENSMUST00000036576.8
 Ccdc138
coiled-coil domain containing 138
chr1_-_74588117 0.048 ENSMUST00000066986.6
 Zfp142
zinc finger protein 142
chr3_+_89773562 0.048 ENSMUST00000038356.8
 Ube2q1
ubiquitin-conjugating enzyme E2Q (putative) 1
chr15_+_51877742 0.043 ENSMUST00000136129.1
 Utp23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr4_+_53011916 0.026 ENSMUST00000107665.3
 Nipsnap3b
nipsnap homolog 3B (C. elegans)
chr7_+_27553244 0.026 ENSMUST00000067386.7
 2310022A10Rik
RIKEN cDNA 2310022A10 gene
chr5_+_121795034 0.021 ENSMUST00000162327.1
 Atxn2
ataxin 2
chr1_+_131153175 0.018 ENSMUST00000112446.2
ENSMUST00000068805.7
ENSMUST00000068791.4
 Eif2d


eukaryotic translation initiation factor 2D


chrX_-_8074720 0.018 ENSMUST00000115636.3
ENSMUST00000115638.3
 Suv39h1

suppressor of variegation 3-9 homolog 1 (Drosophila)

chr9_+_6168601 0.014 ENSMUST00000168039.1
 Pdgfd
platelet-derived growth factor, D polypeptide
chr7_+_12977834 0.010 ENSMUST00000108537.1
ENSMUST00000108535.1
ENSMUST00000045810.7
 Zfp446


zinc finger protein 446


chr6_+_11926758 0.008 ENSMUST00000133776.1
 Phf14
PHD finger protein 14

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.3 1.3 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 0.7 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.2 3.2 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.2 0.5 GO:0045204 MAPK export from nucleus(GO:0045204)
0.2 0.5 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 0.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.3 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 1.0 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 0.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 1.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.3 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.3 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0 0.5 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.2 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.4 GO:0031280 negative regulation of cyclase activity(GO:0031280)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.1 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000343)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.0 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 1.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.5 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0031673 H zone(GO:0031673)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 3.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.7 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.1 0.3 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.1 1.0 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)