Motif ID: Hmga2

Z-value: 1.966


Transcription factors associated with Hmga2:

Gene SymbolEntrez IDGene Name
Hmga2 ENSMUSG00000056758.8 Hmga2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga2mm10_v2_chr10_-_120476469_120476527-0.107.3e-01Click!


Activity profile for motif Hmga2.

activity profile for motif Hmga2


Sorted Z-values histogram for motif Hmga2

Sorted Z-values for motif Hmga2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmga2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_98667264 13.697 ENSMUST00000099683.1
Gm10800
predicted gene 10800
chr9_+_3013140 13.200 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr14_-_19418930 11.931 ENSMUST00000177817.1
Gm21738
predicted gene, 21738
chr9_+_3004457 9.599 ENSMUST00000178348.1
Gm11168
predicted gene 11168
chr9_+_3023547 8.659 ENSMUST00000099046.3
Gm10718
predicted gene 10718
chr9_+_3025417 8.073 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr9_+_3017408 6.936 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr9_+_3018753 6.599 ENSMUST00000179272.1
Gm10719
predicted gene 10719
chr2_+_158375638 2.962 ENSMUST00000109488.1
Snhg11
small nucleolar RNA host gene 11
chr11_+_82035569 2.157 ENSMUST00000000193.5
Ccl2
chemokine (C-C motif) ligand 2
chr5_+_21372642 1.986 ENSMUST00000035799.5
Fgl2
fibrinogen-like protein 2
chr13_-_62607499 1.839 ENSMUST00000091563.4
6720489N17Rik
RIKEN cDNA 6720489N17 gene
chr16_-_43979050 1.749 ENSMUST00000165648.1
ENSMUST00000036321.7
Zdhhc23

zinc finger, DHHC domain containing 23

chr10_+_123264076 1.537 ENSMUST00000050756.7
Fam19a2
family with sequence similarity 19, member A2
chr3_+_53845086 1.527 ENSMUST00000108014.1
Gm10985
predicted gene 10985
chr9_-_123260776 1.394 ENSMUST00000068140.4
Tmem158
transmembrane protein 158
chr11_-_102897123 1.331 ENSMUST00000067444.3
Gfap
glial fibrillary acidic protein
chr19_-_11818806 1.309 ENSMUST00000075304.6
Stx3
syntaxin 3
chr4_+_130913120 1.276 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_44756553 1.111 ENSMUST00000107824.2
Zcchc7
zinc finger, CCHC domain containing 7
chr9_-_8134294 1.046 ENSMUST00000037397.6
AK129341
cDNA sequence AK129341
chrM_+_9452 1.001 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr11_+_75999912 0.992 ENSMUST00000066408.5
1700016K19Rik
RIKEN cDNA 1700016K19 gene
chr13_-_62371936 0.992 ENSMUST00000107989.3
Gm3604
predicted gene 3604
chr9_+_22411515 0.990 ENSMUST00000058868.7
9530077C05Rik
RIKEN cDNA 9530077C05 gene
chr14_+_25980039 0.972 ENSMUST00000173155.1
Duxbl1
double homeobox B-like 1
chrX_-_164980310 0.969 ENSMUST00000004715.1
ENSMUST00000112248.2
Mospd2

motile sperm domain containing 2

chr10_+_25359798 0.950 ENSMUST00000053748.8
Epb4.1l2
erythrocyte protein band 4.1-like 2
chr16_+_87454976 0.918 ENSMUST00000119504.1
ENSMUST00000131356.1
Usp16

ubiquitin specific peptidase 16

chr16_-_26371828 0.910 ENSMUST00000023154.2
Cldn1
claudin 1
chrX_-_16817339 0.910 ENSMUST00000040820.6
Maob
monoamine oxidase B
chr14_-_36919513 0.860 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chrM_+_10167 0.847 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr13_-_74482943 0.846 ENSMUST00000074369.6
Zfp825
zinc finger protein 825
chr8_-_84176552 0.844 ENSMUST00000070102.5
Nanos3
nanos homolog 3 (Drosophila)
chr1_+_172698046 0.809 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr15_-_84065329 0.789 ENSMUST00000156187.1
Efcab6
EF-hand calcium binding domain 6
chr14_-_36919314 0.783 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr1_+_136676413 0.781 ENSMUST00000181491.1
Gm19705
predicted gene, 19705
chr2_+_5951440 0.756 ENSMUST00000060092.6
Upf2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr17_+_40811089 0.666 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr9_+_122351723 0.650 ENSMUST00000111497.3
Abhd5
abhydrolase domain containing 5
chr4_+_57637816 0.628 ENSMUST00000150412.1
Gm20459
predicted gene 20459
chr5_-_106926245 0.582 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr9_+_122351555 0.560 ENSMUST00000156520.1
Abhd5
abhydrolase domain containing 5
chrX_+_37126777 0.559 ENSMUST00000016553.4
Nkap
NFKB activating protein
chr11_-_102897146 0.559 ENSMUST00000077902.4
Gfap
glial fibrillary acidic protein
chr4_-_36136463 0.537 ENSMUST00000098151.2
Lingo2
leucine rich repeat and Ig domain containing 2
chr7_-_97738222 0.523 ENSMUST00000084986.6
Aqp11
aquaporin 11
chr16_-_89508313 0.521 ENSMUST00000056118.2
Krtap7-1
keratin associated protein 7-1
chr11_+_77462325 0.506 ENSMUST00000102493.1
Coro6
coronin 6
chr6_+_21949571 0.486 ENSMUST00000031680.3
ENSMUST00000115389.1
ENSMUST00000151473.1
Ing3


inhibitor of growth family, member 3


chr10_+_58446845 0.481 ENSMUST00000003310.5
Ranbp2
RAN binding protein 2
chr7_+_45526330 0.473 ENSMUST00000120985.1
ENSMUST00000051810.8
Plekha4

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4

chrX_+_103356464 0.467 ENSMUST00000116547.2
Chic1
cysteine-rich hydrophobic domain 1
chr3_-_152210032 0.451 ENSMUST00000144950.1
Dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_+_135485605 0.443 ENSMUST00000029814.9
Manba
mannosidase, beta A, lysosomal
chr1_+_93235836 0.440 ENSMUST00000062202.7
Sned1
sushi, nidogen and EGF-like domains 1
chr10_-_117282262 0.421 ENSMUST00000092163.7
Lyz2
lysozyme 2
chr7_+_49975228 0.414 ENSMUST00000107603.1
Nell1
NEL-like 1
chr4_-_58912678 0.396 ENSMUST00000144512.1
ENSMUST00000102889.3
ENSMUST00000055822.8
AI314180


expressed sequence AI314180


chr17_-_6961156 0.396 ENSMUST00000063683.6
Tagap1
T cell activation GTPase activating protein 1
chr9_-_97111117 0.386 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr4_-_25281801 0.378 ENSMUST00000102994.3
Ufl1
UFM1 specific ligase 1
chr18_+_37411674 0.369 ENSMUST00000051126.2
Pcdhb10
protocadherin beta 10
chr19_-_5510467 0.364 ENSMUST00000070172.4
Snx32
sorting nexin 32
chr10_+_29313500 0.358 ENSMUST00000020034.4
Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr12_-_23780265 0.349 ENSMUST00000072014.4
Gm10330
predicted gene 10330
chr13_+_104178797 0.343 ENSMUST00000022225.5
ENSMUST00000069187.5
Trim23

tripartite motif-containing 23

chr2_+_62664279 0.328 ENSMUST00000028257.2
Gca
grancalcin
chr4_-_32923455 0.325 ENSMUST00000035719.4
ENSMUST00000084749.1
Ankrd6

ankyrin repeat domain 6

chr1_+_46066738 0.321 ENSMUST00000069293.7
Dnah7b
dynein, axonemal, heavy chain 7B
chr16_-_18876522 0.318 ENSMUST00000119273.1
Mrpl40
mitochondrial ribosomal protein L40
chr2_+_19344317 0.308 ENSMUST00000141289.1
4930447M23Rik
RIKEN cDNA 4930447M23 gene
chr4_+_126286792 0.307 ENSMUST00000070132.6
Col8a2
collagen, type VIII, alpha 2
chr2_+_29124106 0.294 ENSMUST00000129544.1
Setx
senataxin
chr16_-_18876655 0.294 ENSMUST00000023391.8
Mrpl40
mitochondrial ribosomal protein L40
chr19_+_12573508 0.292 ENSMUST00000025595.4
Fam111a
family with sequence similarity 111, member A
chr1_-_24612700 0.288 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr1_+_55131253 0.266 ENSMUST00000027122.7
Mob4
MOB family member 4, phocein
chrX_-_38576166 0.249 ENSMUST00000050083.5
Cul4b
cullin 4B
chr9_+_75037838 0.248 ENSMUST00000169188.1
Arpp19
cAMP-regulated phosphoprotein 19
chrM_+_9870 0.243 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr16_+_33185045 0.221 ENSMUST00000039733.8
Osbpl11
oxysterol binding protein-like 11
chr6_-_106800051 0.220 ENSMUST00000013882.7
ENSMUST00000049675.4
ENSMUST00000113239.3
Crbn


cereblon


chr7_-_42642547 0.213 ENSMUST00000098503.2
9830147E19Rik
RIKEN cDNA 9830147E19 gene
chr2_-_102901346 0.208 ENSMUST00000111192.2
ENSMUST00000111190.2
ENSMUST00000111198.2
ENSMUST00000111191.2
ENSMUST00000060516.7
ENSMUST00000099673.2
ENSMUST00000005218.8
ENSMUST00000111194.1
Cd44







CD44 antigen







chr3_+_88214474 0.206 ENSMUST00000181356.1
ENSMUST00000181396.1
Gm3764

predicted gene 3764

chrX_-_95956890 0.191 ENSMUST00000079987.6
ENSMUST00000113864.2
Las1l

LAS1-like (S. cerevisiae)

chr2_-_122702615 0.189 ENSMUST00000005952.4
ENSMUST00000099457.3
Slc30a4

solute carrier family 30 (zinc transporter), member 4

chr2_-_75981967 0.188 ENSMUST00000099994.3
Ttc30a1
tetratricopeptide repeat domain 30A1
chr9_+_70012540 0.171 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
Gtf2a2




general transcription factor II A, 2




chr7_-_5413145 0.162 ENSMUST00000108569.2
Vmn1r58
vomeronasal 1 receptor 58
chr17_+_36958571 0.160 ENSMUST00000040177.6
Znrd1as
Znrd1 antisense
chr1_-_144004142 0.149 ENSMUST00000127206.1
Rgs2
regulator of G-protein signaling 2
chr11_+_108682602 0.149 ENSMUST00000106718.3
ENSMUST00000106715.1
ENSMUST00000106724.3
Cep112


centrosomal protein 112


chr16_-_76403673 0.127 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr16_+_29579331 0.114 ENSMUST00000160597.1
Opa1
optic atrophy 1
chr10_+_94550852 0.113 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3

transmembrane and coiled coil domains 3

chr4_-_139380374 0.112 ENSMUST00000181556.1
2700016F22Rik
RIKEN cDNA 2700016F22 gene
chr18_-_35662180 0.110 ENSMUST00000025209.4
ENSMUST00000096573.2
Spata24

spermatogenesis associated 24

chrX_-_36991724 0.084 ENSMUST00000152291.1
Sept6
septin 6
chr4_-_150003130 0.078 ENSMUST00000084117.6
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr4_+_44756609 0.077 ENSMUST00000143385.1
Zcchc7
zinc finger, CCHC domain containing 7
chr7_-_12422488 0.069 ENSMUST00000120220.1
Zfp551
zinc fingr protein 551
chrX_-_57393020 0.066 ENSMUST00000143310.1
ENSMUST00000098470.2
ENSMUST00000114726.1
Rbmx


RNA binding motif protein, X chromosome


chr16_+_32277449 0.061 ENSMUST00000155649.1
ENSMUST00000014218.8
ENSMUST00000171474.1
Rnf168


ring finger protein 168


chr19_+_46689902 0.056 ENSMUST00000074912.7
2010012O05Rik
RIKEN cDNA 2010012O05 gene
chr9_+_13619990 0.041 ENSMUST00000159294.1
Maml2
mastermind like 2 (Drosophila)
chr5_-_96164147 0.036 ENSMUST00000137207.1
Cnot6l
CCR4-NOT transcription complex, subunit 6-like
chr2_-_84678828 0.031 ENSMUST00000111665.1
Tmx2
thioredoxin-related transmembrane protein 2
chr9_+_92309362 0.025 ENSMUST00000098477.1
ENSMUST00000150594.1
1700057G04Rik

RIKEN cDNA 1700057G04 gene

chr17_+_73107982 0.023 ENSMUST00000130574.1
ENSMUST00000149064.1
ENSMUST00000067545.6
Lclat1


lysocardiolipin acyltransferase 1


chr6_+_125039760 0.019 ENSMUST00000140131.1
ENSMUST00000032480.7
Ing4

inhibitor of growth family, member 4

chr11_+_105178765 0.014 ENSMUST00000106939.2
Tlk2
tousled-like kinase 2 (Arabidopsis)
chr2_+_27676440 0.009 ENSMUST00000129514.1
Rxra
retinoid X receptor alpha
chr5_+_14514918 0.005 ENSMUST00000030691.10
ENSMUST00000182407.1
Pclo

piccolo (presynaptic cytomatrix protein)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.4 1.2 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.3 1.0 GO:0016598 protein arginylation(GO:0016598)
0.3 1.9 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.3 0.9 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.2 0.9 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) histone H2A K63-linked deubiquitination(GO:0070537)
0.2 0.5 GO:0048388 endosomal lumen acidification(GO:0048388)
0.2 1.3 GO:0016081 synaptic vesicle docking(GO:0016081)
0.1 0.8 GO:0032929 negative regulation of macrophage derived foam cell differentiation(GO:0010745) negative regulation of superoxide anion generation(GO:0032929)
0.1 0.7 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 2.4 GO:0019835 cytolysis(GO:0019835)
0.1 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.2 GO:2000561 CD4-positive, alpha-beta T cell proliferation(GO:0035739) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.1 0.5 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.6 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 0.4 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 1.7 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.4 GO:2000598 regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.1 0.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.8 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.8 GO:0031100 organ regeneration(GO:0031100)
0.0 0.1 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.6 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.2 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 1.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.6 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.4 GO:0006862 nucleotide transport(GO:0006862)
0.0 0.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0044299 C-fiber(GO:0044299)
0.5 1.9 GO:0097450 astrocyte end-foot(GO:0097450)
0.3 1.3 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.1 0.3 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.2 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0005940 septin ring(GO:0005940)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 2.0 GO:0070469 respiratory chain(GO:0070469)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0030134 multivesicular body(GO:0005771) ER to Golgi transport vesicle(GO:0030134)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.7 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.3 GO:0050544 arachidonic acid binding(GO:0050544)
0.2 0.8 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.4 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.4 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 1.2 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.3 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.1 1.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.1 2.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.5 GO:0015250 water channel activity(GO:0015250)
0.0 0.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 1.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.5 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)