Motif ID: Runx3

Z-value: 0.765


Transcription factors associated with Runx3:

Gene SymbolEntrez IDGene Name
Runx3 ENSMUSG00000070691.4 Runx3



Activity profile for motif Runx3.

activity profile for motif Runx3


Sorted Z-values histogram for motif Runx3

Sorted Z-values for motif Runx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_40655020 3.133 ENSMUST00000053467.4
 Zfpm2
zinc finger protein, multitype 2
chr3_+_121953213 2.646 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr18_-_47368446 1.559 ENSMUST00000076043.6
ENSMUST00000135790.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chrX_-_73869804 1.152 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr11_+_75532127 1.152 ENSMUST00000127226.1
 Slc43a2
solute carrier family 43, member 2
chr11_+_75532099 1.150 ENSMUST00000169547.2
 Slc43a2
solute carrier family 43, member 2
chr5_+_21424934 1.114 ENSMUST00000056045.4
 Fam185a
family with sequence similarity 185, member A
chr13_-_51734695 1.021 ENSMUST00000110039.1
 Sema4d
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr7_+_35802593 1.014 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr1_-_24100306 0.909 ENSMUST00000027337.8
 Fam135a
family with sequence similarity 135, member A
chr6_-_100671126 0.810 ENSMUST00000089245.6
ENSMUST00000113312.2
ENSMUST00000170667.1
 Shq1


SHQ1 homolog (S. cerevisiae)


chr10_+_128083273 0.789 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr13_-_25020289 0.760 ENSMUST00000021772.2
 Mrs2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr7_-_35802968 0.698 ENSMUST00000061586.4
 Zfp507
zinc finger protein 507
chrX_+_99136119 0.659 ENSMUST00000052839.6
 Efnb1
ephrin B1
chr17_+_27556613 0.658 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr17_+_27556641 0.654 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr17_+_27556668 0.625 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chr10_-_62602261 0.613 ENSMUST00000045866.7
 Ddx21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chrX_-_98890781 0.600 ENSMUST00000113826.1
ENSMUST00000033560.2
ENSMUST00000142267.1
 Ophn1


oligophrenin 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.1 GO:0003195 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0 2.7 GO:0015807 L-amino acid transport(GO:0015807)
0.0 1.9 GO:0006284 base-excision repair(GO:0006284)
0.1 1.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 1.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.3 1.0 GO:1900220 negative regulation of alkaline phosphatase activity(GO:0010693) semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.3 0.8 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.2 0.8 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.8 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 0.7 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.7 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.2 0.6 GO:0046077 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.1 0.6 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.6 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.6 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.0 0.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 0.5 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.5 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1 0.5 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.2 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.8 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 0.6 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 0.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.5 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.4 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.3 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0097431 mitotic spindle pole(GO:0097431)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 2.6 GO:0030165 PDZ domain binding(GO:0030165)
0.1 2.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 1.9 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.2 1.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.7 GO:0051434 BH3 domain binding(GO:0051434)
0.2 0.6 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.2 0.6 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.6 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 0.5 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.5 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.5 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.1 0.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.4 GO:0003883 CTP synthase activity(GO:0003883)