Motif ID: Foxo4

Z-value: 1.140


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.263.7e-01Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Showing 1 to 20 of 85 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103813913 3.752 ENSMUST00000098192.3
Hbb-bt
hemoglobin, beta adult t chain
chr4_-_97778042 2.456 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_+_6487231 1.990 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr4_+_97777606 1.762 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr2_-_175338197 1.757 ENSMUST00000121393.2
Gm4631
predicted gene 4631
chr2_-_175931051 1.690 ENSMUST00000108949.2
ENSMUST00000109018.2
Gm8898

predicted gene 8898

chr2_-_177957239 1.512 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
Gm14326


predicted gene 14326


chr2_+_176521056 1.449 ENSMUST00000108997.2
ENSMUST00000178443.1
Gm14431

predicted gene 14431

chr17_+_80944611 1.393 ENSMUST00000025092.4
Tmem178
transmembrane protein 178
chr2_-_175141999 1.273 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
Gm14399


predicted gene 14399


chr2_+_175372436 1.241 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chr14_-_25903100 1.233 ENSMUST00000052286.8
Plac9a
placenta specific 9a
chr14_-_26182480 1.199 ENSMUST00000184142.1
Plac9b
placenta specific 9b
chr2_+_175469985 1.136 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr2_-_175703646 1.135 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr2_-_177840318 1.098 ENSMUST00000108939.2
ENSMUST00000150650.1
Gm14325

predicted gene 14325

chr2_+_178023284 1.076 ENSMUST00000108925.3
ENSMUST00000108926.2
Etohi1

ethanol induced 1

chr19_-_50030735 1.056 ENSMUST00000071866.1
Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr2_+_175965331 1.007 ENSMUST00000109007.1
ENSMUST00000174416.1
Gm2026

predicted gene 2026

chr2_+_176670522 0.984 ENSMUST00000121956.1
ENSMUST00000108985.2
Gm14306

predicted gene 14306


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0060074 synapse maturation(GO:0060074)
0.1 1.6 GO:0060539 diaphragm development(GO:0060539)
0.1 1.4 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 1.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.9 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.2 0.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 0.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.6 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.2 0.5 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0 0.5 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.4 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.3 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 0.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.3 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.3 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.3 GO:0006983 ER overload response(GO:0006983)
0.1 0.2 GO:0032829 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) negative regulation of interleukin-2 biosynthetic process(GO:0045085) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.2 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)

Gene overrepresentation in cellular_component category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.0 GO:0072562 blood microparticle(GO:0072562)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.8 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 1.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.5 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.1 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)