Motif ID: Foxo4

Z-value: 1.140


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.263.7e-01Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_103813913 3.752 ENSMUST00000098192.3
Hbb-bt
hemoglobin, beta adult t chain
chr4_-_97778042 2.456 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_+_6487231 1.990 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr4_+_97777606 1.762 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr2_-_175338197 1.757 ENSMUST00000121393.2
Gm4631
predicted gene 4631
chr2_-_175931051 1.690 ENSMUST00000108949.2
ENSMUST00000109018.2
Gm8898

predicted gene 8898

chr2_-_177957239 1.512 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
Gm14326


predicted gene 14326


chr2_+_176521056 1.449 ENSMUST00000108997.2
ENSMUST00000178443.1
Gm14431

predicted gene 14431

chr17_+_80944611 1.393 ENSMUST00000025092.4
Tmem178
transmembrane protein 178
chr2_-_175141999 1.273 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
Gm14399


predicted gene 14399


chr2_+_175372436 1.241 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chr14_-_25903100 1.233 ENSMUST00000052286.8
Plac9a
placenta specific 9a
chr14_-_26182480 1.199 ENSMUST00000184142.1
Plac9b
placenta specific 9b
chr2_+_175469985 1.136 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr2_-_175703646 1.135 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr2_-_177840318 1.098 ENSMUST00000108939.2
ENSMUST00000150650.1
Gm14325

predicted gene 14325

chr2_+_178023284 1.076 ENSMUST00000108925.3
ENSMUST00000108926.2
Etohi1

ethanol induced 1

chr19_-_50030735 1.056 ENSMUST00000071866.1
Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr2_+_175965331 1.007 ENSMUST00000109007.1
ENSMUST00000174416.1
Gm2026

predicted gene 2026

chr2_+_176670522 0.984 ENSMUST00000121956.1
ENSMUST00000108985.2
Gm14306

predicted gene 14306

chr2_+_176226569 0.936 ENSMUST00000099009.2
ENSMUST00000136719.1
2210418O10Rik

RIKEN cDNA 2210418O10 gene

chr12_+_75308308 0.915 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr14_+_32028989 0.893 ENSMUST00000022460.4
Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr2_+_181767283 0.863 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chrX_-_166585679 0.863 ENSMUST00000000412.2
Egfl6
EGF-like-domain, multiple 6
chr2_+_177000956 0.805 ENSMUST00000108975.2
ENSMUST00000156844.1
Gm14419

predicted gene 14419

chr11_-_77078404 0.786 ENSMUST00000102494.1
Ccdc55
coiled-coil domain containing 55
chr2_-_176927809 0.782 ENSMUST00000099007.2
Gm14296
predicted gene 14296
chr2_+_176708328 0.733 ENSMUST00000108981.2
ENSMUST00000108980.2
Gm14305

predicted gene 14305

chr2_+_181767040 0.723 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr9_+_107906866 0.705 ENSMUST00000035203.7
Mst1r
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
chr1_+_171437535 0.685 ENSMUST00000043839.4
F11r
F11 receptor
chr6_+_42286676 0.685 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr2_+_175869219 0.675 ENSMUST00000109011.1
Gm6710
predicted gene 6710
chr2_-_177206421 0.673 ENSMUST00000108964.1
Gm14410
predicted gene 14410
chr14_-_98169542 0.662 ENSMUST00000069334.7
ENSMUST00000071533.6
Dach1

dachshund 1 (Drosophila)

chr2_-_175435782 0.647 ENSMUST00000152941.1
ENSMUST00000109045.2
Gm4724

predicted gene 4724

chr2_-_176636318 0.632 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
Gm14308


predicted gene 14308


chr2_-_175206899 0.612 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
Gm14391



predicted gene 14391



chr8_+_26119361 0.610 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
Rnf170



ring finger protein 170



chr2_+_176798612 0.593 ENSMUST00000118012.2
Gm14295
predicted gene 14295
chr7_-_27355944 0.587 ENSMUST00000003857.6
Shkbp1
Sh3kbp1 binding protein 1
chr15_-_35938009 0.550 ENSMUST00000156915.1
Cox6c
cytochrome c oxidase subunit VIc
chr2_-_176486773 0.543 ENSMUST00000120959.1
ENSMUST00000120521.1
Gm14434

predicted gene 14434

chr11_-_102365111 0.542 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr2_-_178078425 0.493 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
Zfp931


zinc finger protein 931


chr15_-_80014808 0.493 ENSMUST00000000500.6
Pdgfb
platelet derived growth factor, B polypeptide
chr6_+_42286709 0.468 ENSMUST00000163936.1
Clcn1
chloride channel 1
chrX_-_134600976 0.431 ENSMUST00000033621.6
Gla
galactosidase, alpha
chr8_-_45410539 0.349 ENSMUST00000034056.4
ENSMUST00000167106.1
Tlr3

toll-like receptor 3

chr11_+_101246960 0.346 ENSMUST00000107282.3
Ramp2
receptor (calcitonin) activity modifying protein 2
chr10_-_53638269 0.314 ENSMUST00000164393.1
Fam184a
family with sequence similarity 184, member A
chr19_-_5796924 0.313 ENSMUST00000174808.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr18_-_38918642 0.301 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr13_-_91223955 0.292 ENSMUST00000022119.4
Atg10
autophagy related 10
chr13_-_117025505 0.279 ENSMUST00000022239.6
Parp8
poly (ADP-ribose) polymerase family, member 8
chr4_+_8690399 0.271 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr8_+_79639618 0.265 ENSMUST00000173078.1
ENSMUST00000173286.1
Otud4

OTU domain containing 4

chr17_-_23745829 0.254 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr5_+_139543889 0.250 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chrX_+_7579666 0.249 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3

forkhead box P3

chr7_-_139582790 0.243 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr15_-_35938186 0.222 ENSMUST00000014457.8
Cox6c
cytochrome c oxidase subunit VIc
chr17_+_36869567 0.216 ENSMUST00000060524.9
Trim10
tripartite motif-containing 10
chr12_+_69893105 0.216 ENSMUST00000021466.8
Atl1
atlastin GTPase 1
chr18_-_6490808 0.208 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr6_-_128424883 0.194 ENSMUST00000001559.8
Itfg2
integrin alpha FG-GAP repeat containing 2
chr5_-_24445254 0.166 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr5_-_24445166 0.161 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr15_-_97767798 0.160 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr11_-_102579461 0.095 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr8_-_94012120 0.081 ENSMUST00000143265.1
Amfr
autocrine motility factor receptor
chr12_-_69892989 0.077 ENSMUST00000110567.1
ENSMUST00000171211.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr6_+_56714891 0.066 ENSMUST00000031805.8
Avl9
AVL9 homolog (S. cerevisiase)
chr11_+_101155884 0.060 ENSMUST00000043654.9
Tubg2
tubulin, gamma 2
chr14_-_32085595 0.050 ENSMUST00000022461.4
ENSMUST00000067955.5
ENSMUST00000124303.1
ENSMUST00000112000.1
Dph3



diphthamine biosynthesis 3



chr7_-_3629874 0.046 ENSMUST00000155592.1
ENSMUST00000108641.3
Tfpt

TCF3 (E2A) fusion partner

chr4_-_32950813 0.046 ENSMUST00000084750.1
ENSMUST00000084748.2
Ankrd6

ankyrin repeat domain 6

chr1_+_133309778 0.038 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
Golt1a

Kiss1

GOLT1A
golgi transport 1 homolog A (S. cerevisiae)

KiSS-1 metastasis-suppressor

KISS1 isoform e
chr13_-_8940977 0.032 ENSMUST00000071184.2
Rpl10a-ps2
ribosomal protein L10A, pseudogene 2
chr11_+_3290300 0.027 ENSMUST00000057089.6
ENSMUST00000093402.5
Patz1

POZ (BTB) and AT hook containing zinc finger 1

chr9_+_57076395 0.026 ENSMUST00000168177.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr4_+_130360132 0.024 ENSMUST00000105994.3
Snrnp40
small nuclear ribonucleoprotein 40 (U5)
chr7_+_29303958 0.015 ENSMUST00000049977.6
Dpf1
D4, zinc and double PHD fingers family 1
chr9_+_45954101 0.015 ENSMUST00000181487.1
A830035O19Rik
RIKEN cDNA A830035O19 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.2 0.5 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 1.6 GO:0060539 diaphragm development(GO:0060539)
0.1 0.3 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 1.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 1.4 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 0.2 GO:0032829 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) negative regulation of interleukin-2 biosynthetic process(GO:0045085) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 0.3 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.9 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.4 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 1.8 GO:0060074 synapse maturation(GO:0060074)
0.0 0.2 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.0 0.3 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.2 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.3 GO:0006983 ER overload response(GO:0006983)
0.0 0.5 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.6 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.0 0.2 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 1.0 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.8 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 0.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.5 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)