Motif ID: Sox3_Sox10

Z-value: 1.757

Transcription factors associated with Sox3_Sox10:

Gene SymbolEntrez IDGene Name
Sox10 ENSMUSG00000033006.9 Sox10
Sox3 ENSMUSG00000045179.8 Sox3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox10mm10_v2_chr15_-_79164477_79164496-0.751.9e-03Click!
Sox3mm10_v2_chrX_-_60893430_608934400.451.1e-01Click!


Activity profile for motif Sox3_Sox10.

activity profile for motif Sox3_Sox10


Sorted Z-values histogram for motif Sox3_Sox10

Sorted Z-values for motif Sox3_Sox10



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox3_Sox10

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_51432663 9.401 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr12_-_31713873 8.711 ENSMUST00000057783.4
ENSMUST00000174480.2
ENSMUST00000176710.1
 Gpr22


G protein-coupled receptor 22


chr11_+_67586675 7.941 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr4_-_82705735 7.676 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chr6_+_51432678 7.062 ENSMUST00000160133.1
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr4_+_102254739 6.822 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chrX_-_143933089 6.250 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_+_158666690 5.590 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr11_+_67586520 5.430 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr6_-_99028874 5.058 ENSMUST00000154163.2
 Foxp1
forkhead box P1
chr1_+_66322102 4.903 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr18_-_43059418 4.859 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr18_-_47333311 4.826 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr3_+_65109343 4.337 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr5_+_66968559 4.207 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr13_-_56252163 4.180 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr7_-_120982260 4.130 ENSMUST00000033169.8
 Cdr2
cerebellar degeneration-related 2
chr2_-_64975762 4.085 ENSMUST00000156765.1
 Grb14
growth factor receptor bound protein 14
chr6_+_17065129 3.951 ENSMUST00000115467.4
ENSMUST00000154266.2
ENSMUST00000076654.7
 Tes


testis derived transcript


chr1_+_66321708 3.871 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 370 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 13.6 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 11.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.5 9.1 GO:0021860 pyramidal neuron development(GO:0021860)
1.1 8.8 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 8.4 GO:0051017 actin filament bundle assembly(GO:0051017)
0.4 7.8 GO:2001224 positive regulation of neuron migration(GO:2001224)
1.9 7.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.6 7.0 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
1.0 6.8 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.4 6.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.6 5.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 5.7 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
1.4 5.6 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.7 5.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.4 5.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 5.5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 5.1 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.7 4.9 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.2 4.9 GO:0048266 behavioral response to pain(GO:0048266)
0.3 4.8 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.0 GO:0001726 ruffle(GO:0001726)
0.5 11.1 GO:0000930 gamma-tubulin complex(GO:0000930)
1.2 11.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 10.9 GO:0043034 costamere(GO:0043034)
0.4 10.5 GO:0071565 nBAF complex(GO:0071565)
0.4 7.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 7.2 GO:0005874 microtubule(GO:0005874)
0.3 7.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 6.0 GO:0005829 cytosol(GO:0005829)
0.1 5.7 GO:0043204 perikaryon(GO:0043204)
0.1 5.4 GO:0031941 filamentous actin(GO:0031941)
0.1 5.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 4.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 4.9 GO:0005871 kinesin complex(GO:0005871)
0.8 4.8 GO:1990635 proximal dendrite(GO:1990635)
0.1 4.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 4.3 GO:0044295 axonal growth cone(GO:0044295)
0.1 4.2 GO:0043198 dendritic shaft(GO:0043198)
1.3 3.9 GO:0002142 stereocilia ankle link complex(GO:0002142)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 244 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.3 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.1 11.0 GO:0051015 actin filament binding(GO:0051015)
0.1 10.9 GO:0003779 actin binding(GO:0003779)
1.3 10.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 9.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 8.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 8.3 GO:0042277 peptide binding(GO:0042277)
0.2 7.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.4 7.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.0 6.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 6.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 6.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 6.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 6.1 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.9 6.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.6 5.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.2 5.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 4.9 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.5 4.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 4.4 GO:0003785 actin monomer binding(GO:0003785)