Motif ID: Nr4a2

Z-value: 0.925


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57113053_571130720.714.3e-03Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 109 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_86711059 2.945 ENSMUST00000068423.3
 Cbln2
cerebellin 2 precursor protein
chr6_-_99096196 2.447 ENSMUST00000175886.1
 Foxp1
forkhead box P1
chr6_-_59024340 2.207 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr6_-_59024470 2.082 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr13_+_93303757 2.013 ENSMUST00000109494.1
 Homer1
homer homolog 1 (Drosophila)
chr5_+_150259922 1.907 ENSMUST00000087204.5
 Fry
furry homolog (Drosophila)
chr8_+_68880491 1.737 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr6_-_138422898 1.728 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
 Lmo3


LIM domain only 3


chr10_-_42478280 1.683 ENSMUST00000151747.1
 Lace1
lactation elevated 1
chr10_-_42478488 1.643 ENSMUST00000041024.8
 Lace1
lactation elevated 1
chr2_+_121295437 1.583 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr6_+_96113146 1.571 ENSMUST00000122120.1
 Fam19a1
family with sequence similarity 19, member A1
chr18_-_56975333 1.459 ENSMUST00000139243.2
ENSMUST00000025488.8
 C330018D20Rik

RIKEN cDNA C330018D20 gene

chr13_+_118714678 1.436 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr17_-_17624458 1.431 ENSMUST00000041047.2
 Lnpep
leucyl/cystinyl aminopeptidase
chr11_-_70656467 1.293 ENSMUST00000131642.1
 Gm12319
predicted gene 12319
chr5_+_111581422 1.270 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr16_+_8830093 1.267 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chrX_+_152233228 1.164 ENSMUST00000112588.2
ENSMUST00000082177.6
 Kdm5c

lysine (K)-specific demethylase 5C

chr5_+_30232581 1.135 ENSMUST00000145167.1
 Ept1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 3.0 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.3 2.4 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 1.9 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.6 1.8 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.4 1.7 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 1.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.5 1.6 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 1.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.5 1.4 GO:0071336 lung growth(GO:0060437) positive regulation of fat cell proliferation(GO:0070346) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.1 1.4 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.4 GO:0097320 membrane tubulation(GO:0097320)
0.1 1.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.2 1.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 1.0 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 1.0 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 0.8 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 0.8 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.1 0.8 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0043034 costamere(GO:0043034)
0.1 1.8 GO:0035861 site of double-strand break(GO:0035861)
0.2 1.7 GO:0042627 chylomicron(GO:0042627)
0.1 1.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 1.0 GO:0016460 myosin II complex(GO:0016460)
0.0 1.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.7 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.1 0.6 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.1 0.4 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.3 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.0 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 1.8 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 1.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 1.6 GO:0019808 polyamine binding(GO:0019808)
0.4 1.4 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 1.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 1.2 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.4 1.1 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 1.1 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 0.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.1 0.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 0.7 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.7 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)