Motif ID: Nr4a2
Z-value: 0.925
Transcription factors associated with Nr4a2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nr4a2 | ENSMUSG00000026826.7 | Nr4a2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr4a2 | mm10_v2_chr2_-_57113053_57113072 | 0.71 | 4.3e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.8 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
| 0.5 | 1.6 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.5 | 1.4 | GO:0071336 | lung growth(GO:0060437) positive regulation of fat cell proliferation(GO:0070346) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 0.4 | 1.7 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.3 | 2.4 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.3 | 0.8 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.2 | 0.7 | GO:0019405 | alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) |
| 0.2 | 0.6 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.2 | 1.9 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.2 | 0.6 | GO:0070973 | COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.2 | 3.0 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
| 0.2 | 0.5 | GO:1902109 | negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109) |
| 0.2 | 1.1 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.1 | 0.6 | GO:0010796 | regulation of multivesicular body size(GO:0010796) |
| 0.1 | 1.2 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.1 | 1.0 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.1 | 1.0 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 0.8 | GO:1903624 | regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624) |
| 0.1 | 0.6 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.1 | 0.8 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.1 | 0.7 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.1 | 1.4 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.0 | 1.4 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.0 | 0.4 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.0 | 0.7 | GO:0006308 | DNA catabolic process(GO:0006308) |
| 0.0 | 0.4 | GO:0070301 | cellular response to hydrogen peroxide(GO:0070301) |
| 0.0 | 0.5 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.0 | 1.6 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.0 | 0.7 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.0 | 3.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.3 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.0 | 1.7 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 0.4 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.0 | 0.8 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.3 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
| 0.0 | 0.7 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.0 | 0.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.3 | GO:0046628 | positive regulation of insulin receptor signaling pathway(GO:0046628) |
| 0.0 | 0.3 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 0.0 | 0.7 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.0 | GO:0035811 | negative regulation of urine volume(GO:0035811) |
| 0.0 | 0.3 | GO:1900078 | positive regulation of cellular response to insulin stimulus(GO:1900078) |
| 0.0 | 0.5 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 0.4 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.0 | 0.6 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.0 | 0.4 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 0.1 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.7 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 1.1 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 1.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 0.6 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 0.6 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.1 | 3.0 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 1.0 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 0.3 | GO:0034715 | U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715) |
| 0.1 | 0.4 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.1 | 1.8 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 0.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.7 | GO:0000780 | condensed nuclear chromosome, centromeric region(GO:0000780) |
| 0.0 | 0.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 1.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.3 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 1.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.0 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.4 | 1.6 | GO:0019808 | polyamine binding(GO:0019808) |
| 0.4 | 1.1 | GO:0004307 | ethanolaminephosphotransferase activity(GO:0004307) |
| 0.4 | 1.4 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.3 | 0.8 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.2 | 1.8 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 1.2 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.2 | 1.2 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.2 | 1.7 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.2 | 0.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 0.7 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
| 0.1 | 0.7 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.1 | 0.6 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 0.7 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.1 | 1.4 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.3 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.1 | 0.7 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 0.4 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 0.6 | GO:0004438 | phosphatidylinositol-3-phosphatase activity(GO:0004438) |
| 0.0 | 0.9 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.3 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.0 | 1.1 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 0.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 1.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.4 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.0 | 0.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 1.2 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.0 | 2.0 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.4 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.5 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.8 | GO:0005518 | collagen binding(GO:0005518) |
