Motif ID: Smad2

Z-value: 0.878


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76241892_76242046-0.705.6e-03Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_57694651 3.706 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr4_+_117849361 3.211 ENSMUST00000163288.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr4_+_117849193 3.054 ENSMUST00000132043.2
ENSMUST00000169990.1
 Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr6_-_6882068 2.832 ENSMUST00000142635.1
ENSMUST00000052609.8
 Dlx5

distal-less homeobox 5

chr8_-_105637403 2.800 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr1_-_172297989 2.481 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr11_+_63131512 2.315 ENSMUST00000018361.3
 Pmp22
peripheral myelin protein 22
chr8_-_105637350 2.002 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr18_+_40258361 1.981 ENSMUST00000091927.4
 Kctd16
potassium channel tetramerisation domain containing 16
chr14_-_31168587 1.932 ENSMUST00000036618.7
 Stab1
stabilin 1
chr19_+_59458372 1.816 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr8_+_66386292 1.734 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr5_-_113800356 1.679 ENSMUST00000160374.1
ENSMUST00000067853.5
 Tmem119

transmembrane protein 119

chr3_-_116968827 1.615 ENSMUST00000119557.1
 Palmd
palmdelphin
chr13_-_78199757 1.597 ENSMUST00000091458.6
 Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr10_-_49788743 1.570 ENSMUST00000105483.1
ENSMUST00000105487.1
 Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr3_-_116968969 1.547 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr16_+_64851991 1.131 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr7_+_82867327 1.114 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr15_+_102102926 1.075 ENSMUST00000169627.1
ENSMUST00000046144.9
 Tenc1

tensin like C1 domain-containing phosphatase

chr18_+_11839220 1.022 ENSMUST00000171109.1
ENSMUST00000046948.8
 Cables1

CDK5 and Abl enzyme substrate 1

chr8_+_110721462 0.951 ENSMUST00000052457.8
 Mtss1l
metastasis suppressor 1-like
chr4_+_11191726 0.887 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr11_+_69846665 0.868 ENSMUST00000019605.2
 Plscr3
phospholipid scramblase 3
chr11_+_69846610 0.837 ENSMUST00000152566.1
ENSMUST00000108633.2
 Plscr3

phospholipid scramblase 3

chr17_-_25861456 0.834 ENSMUST00000079461.8
ENSMUST00000176923.1
 Wdr90

WD repeat domain 90

chr9_+_44107286 0.800 ENSMUST00000152956.1
ENSMUST00000114815.1
 C1qtnf5

C1q and tumor necrosis factor related protein 5

chr2_-_128967725 0.792 ENSMUST00000099385.2
 Gm10762
predicted gene 10762
chr2_-_148443543 0.747 ENSMUST00000099269.3
 Cd93
CD93 antigen
chr6_+_83137089 0.735 ENSMUST00000121093.1
ENSMUST00000087938.4
 Rtkn

rhotekin

chr8_-_70439557 0.705 ENSMUST00000076615.5
 Crtc1
CREB regulated transcription coactivator 1
chr4_+_11191354 0.693 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr6_+_125009261 0.673 ENSMUST00000112427.1
 Zfp384
zinc finger protein 384
chr6_+_125009232 0.673 ENSMUST00000112428.1
 Zfp384
zinc finger protein 384
chr11_-_69560186 0.670 ENSMUST00000004036.5
 Efnb3
ephrin B3
chr13_+_96542727 0.595 ENSMUST00000077672.4
ENSMUST00000109444.2
 Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr7_-_45052865 0.494 ENSMUST00000057293.6
 Prr12
proline rich 12
chr17_-_34615965 0.489 ENSMUST00000097345.3
ENSMUST00000015611.7
 Egfl8

EGF-like domain 8

chr10_-_42583628 0.475 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr10_-_37138863 0.449 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr2_+_177768044 0.423 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chr4_-_155010984 0.402 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chrX_-_94123359 0.397 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
 Zfx


zinc finger protein X-linked


chr6_+_125009665 0.380 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
 Zfp384




zinc finger protein 384




chr17_+_7925990 0.333 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr6_-_142702259 0.328 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
 Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr7_+_101321703 0.295 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chr17_-_35980197 0.294 ENSMUST00000055454.7
 Prr3
proline-rich polypeptide 3
chr8_+_109705549 0.269 ENSMUST00000034163.8
 Zfp821
zinc finger protein 821
chr7_-_116237767 0.265 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr18_+_37307445 0.263 ENSMUST00000056712.2
 Pcdhb4
protocadherin beta 4
chr10_-_5069044 0.230 ENSMUST00000095899.3
 Syne1
spectrin repeat containing, nuclear envelope 1
chr8_-_90908415 0.224 ENSMUST00000098517.1
 Gm6658
predicted gene 6658
chr13_-_104816908 0.198 ENSMUST00000022228.6
 Cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr2_-_91950386 0.190 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chr17_-_46032366 0.180 ENSMUST00000071648.5
ENSMUST00000142351.2
ENSMUST00000167860.1
 Vegfa


vascular endothelial growth factor A


chr13_+_23752267 0.180 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr14_-_20496780 0.175 ENSMUST00000022353.3
 Mss51
MSS51 mitochondrial translational activator
chr9_-_119578981 0.123 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr15_+_82252397 0.121 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr16_-_17722879 0.118 ENSMUST00000080936.6
ENSMUST00000012259.7
 Med15

mediator complex subunit 15

chr4_+_148591482 0.111 ENSMUST00000006611.8
 Srm
spermidine synthase
chr7_-_34654342 0.088 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr16_+_32914094 0.063 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
 Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr11_-_75190458 0.047 ENSMUST00000044949.4
 Dph1
DPH1 homolog (S. cerevisiae)
chr14_+_21500879 0.009 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.9 2.8 GO:0060166 olfactory pit development(GO:0060166)
0.8 2.5 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.3 1.7 GO:1903012 positive regulation of bone development(GO:1903012)
0.3 1.1 GO:0072697 protein localization to cell cortex(GO:0072697)
0.2 3.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.2 0.6 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.1 1.6 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 2.3 GO:0032060 bleb assembly(GO:0032060)
0.1 0.5 GO:0021764 amygdala development(GO:0021764)
0.1 1.7 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.7 GO:0016198 axon choice point recognition(GO:0016198)
0.1 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.2 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.1 3.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 0.7 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.3 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 1.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.2 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 1.0 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 1.7 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 1.9 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 3.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 2.0 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.8 GO:0070206 protein trimerization(GO:0070206)
0.0 0.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.0 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 1.6 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 2.3 GO:0043218 compact myelin(GO:0043218)
0.1 1.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 2.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 6.3 GO:0098793 presynapse(GO:0098793)
0.0 2.2 GO:0043197 dendritic spine(GO:0043197)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.3 2.5 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239)
0.3 1.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.9 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 0.7 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.6 GO:0097001 sphingolipid transporter activity(GO:0046624) ceramide binding(GO:0097001)
0.1 1.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 1.7 GO:0042287 MHC protein binding(GO:0042287)
0.1 2.8 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 1.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 3.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)