Motif ID: Nr4a3

Z-value: 0.675


Transcription factors associated with Nr4a3:

Gene SymbolEntrez IDGene Name
Nr4a3 ENSMUSG00000028341.3 Nr4a3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a3mm10_v2_chr4_+_48045144_48045160-0.165.9e-01Click!


Activity profile for motif Nr4a3.

activity profile for motif Nr4a3


Sorted Z-values histogram for motif Nr4a3

Sorted Z-values for motif Nr4a3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_-_1245685 2.136 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chrY_-_1245753 1.173 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr4_+_154960915 1.086 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr1_-_152386675 0.683 ENSMUST00000015124.8
 Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
chr11_-_100822525 0.650 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr7_+_30712209 0.553 ENSMUST00000005692.6
ENSMUST00000170371.1
 Atp4a

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

chr1_-_152386589 0.542 ENSMUST00000162371.1
 Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
chr11_+_113619318 0.512 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr7_-_109616548 0.489 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr11_+_116657106 0.489 ENSMUST00000116318.2
 Gm11744
predicted gene 11744
chr6_-_137571007 0.448 ENSMUST00000100841.2
 Eps8
epidermal growth factor receptor pathway substrate 8
chr8_+_120668222 0.442 ENSMUST00000034276.6
ENSMUST00000181586.1
 Cox4i1

cytochrome c oxidase subunit IV isoform 1

chr3_-_59210881 0.441 ENSMUST00000040622.1
 P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr6_+_113531675 0.410 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr7_-_127345314 0.388 ENSMUST00000060783.5
 Zfp768
zinc finger protein 768
chr12_-_93929102 0.387 ENSMUST00000180321.1
 Gm9726
predicted gene 9726
chr8_+_120668308 0.386 ENSMUST00000181795.1
 Cox4i1
cytochrome c oxidase subunit IV isoform 1
chr6_+_41546730 0.367 ENSMUST00000103299.1
 Trbc2
T cell receptor beta, constant 2
chr9_-_54661666 0.356 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_+_102267795 0.345 ENSMUST00000033289.4
 Stim1
stromal interaction molecule 1
chr5_+_16553488 0.316 ENSMUST00000030683.3
 Hgf
hepatocyte growth factor
chr1_+_137966529 0.309 ENSMUST00000182158.1
 A430106G13Rik
RIKEN cDNA A430106G13 gene
chr4_-_116075022 0.293 ENSMUST00000050580.4
ENSMUST00000078676.5
 Uqcrh

ubiquinol-cytochrome c reductase hinge protein

chr11_-_4704334 0.291 ENSMUST00000058407.5
 Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr15_-_79804717 0.286 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr11_-_61494173 0.280 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
 Mapk7


mitogen-activated protein kinase 7


chr11_-_72266596 0.271 ENSMUST00000021161.6
ENSMUST00000140167.1
 Slc13a5

solute carrier family 13 (sodium-dependent citrate transporter), member 5

chr3_-_95133989 0.267 ENSMUST00000172572.2
ENSMUST00000173462.2
 Scnm1

sodium channel modifier 1

chrX_+_56447965 0.257 ENSMUST00000079663.6
 Gm2174
predicted gene 2174
chr11_-_115536181 0.255 ENSMUST00000118155.1
ENSMUST00000153892.1
 Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr7_-_19715395 0.255 ENSMUST00000032555.9
ENSMUST00000093552.5
 Tomm40

translocase of outer mitochondrial membrane 40 homolog (yeast)

chr11_-_55033398 0.242 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6

chr11_+_70657687 0.229 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr5_+_66968416 0.229 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr12_-_111966954 0.217 ENSMUST00000021719.5
 2010107E04Rik
RIKEN cDNA 2010107E04 gene
chr2_+_79707780 0.217 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
 Ppp1r1c


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr2_+_92375306 0.207 ENSMUST00000028650.8
 Pex16
peroxisomal biogenesis factor 16
chr17_+_29360923 0.205 ENSMUST00000024810.6
 Fgd2
FYVE, RhoGEF and PH domain containing 2
chr14_-_21848924 0.205 ENSMUST00000124549.1
 Comtd1
catechol-O-methyltransferase domain containing 1
chr7_+_45896941 0.202 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr15_+_79141324 0.198 ENSMUST00000040077.6
 Polr2f
polymerase (RNA) II (DNA directed) polypeptide F
chr9_-_22002599 0.188 ENSMUST00000115336.2
ENSMUST00000044926.5
 Ccdc151

coiled-coil domain containing 151

chr3_-_138131356 0.183 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr4_+_131873608 0.165 ENSMUST00000053819.3
 Srsf4
serine/arginine-rich splicing factor 4
chr15_+_76343504 0.158 ENSMUST00000023210.6
 Cyc1
cytochrome c-1
chr4_+_99955715 0.156 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chr3_-_104818539 0.151 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
 Mov10



Moloney leukemia virus 10



chr4_+_116075269 0.145 ENSMUST00000030471.8
 Lrrc41
leucine rich repeat containing 41
chr12_+_4082574 0.144 ENSMUST00000020986.7
 Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr13_-_73328442 0.137 ENSMUST00000022097.5
 Ndufs6
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr8_-_120668058 0.136 ENSMUST00000181950.1
ENSMUST00000181333.1
 Emc8
Gm27021
ER membrane protein complex subunit 8
predicted gene, 27021
chr7_-_126475082 0.130 ENSMUST00000032978.6
 Sh2b1
SH2B adaptor protein 1
chr3_-_89213840 0.129 ENSMUST00000173477.1
ENSMUST00000119222.1
 Mtx1

metaxin 1

chr4_-_150914401 0.127 ENSMUST00000105675.1
 Park7
Parkinson disease (autosomal recessive, early onset) 7
chr1_+_36691487 0.120 ENSMUST00000081180.4
 Cox5b
cytochrome c oxidase subunit Vb
chr15_-_102516806 0.117 ENSMUST00000169162.1
ENSMUST00000023812.2
ENSMUST00000165174.1
ENSMUST00000169367.1
ENSMUST00000169377.1
 Map3k12




mitogen-activated protein kinase kinase kinase 12




chr2_-_180273488 0.114 ENSMUST00000108891.1
 Cables2
CDK5 and Abl enzyme substrate 2
chr12_-_110978981 0.112 ENSMUST00000135131.1
ENSMUST00000043459.6
ENSMUST00000128353.1
 Ankrd9


ankyrin repeat domain 9


chr8_-_120668121 0.108 ENSMUST00000034277.7
 Emc8
ER membrane protein complex subunit 8
chr4_-_139131058 0.108 ENSMUST00000143971.1
 Minos1
mitochondrial inner membrane organizing system 1
chr2_+_59160838 0.107 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
 Pkp4


plakophilin 4


chr9_+_22003035 0.106 ENSMUST00000115331.2
ENSMUST00000003493.7
 Prkcsh

protein kinase C substrate 80K-H

chr12_-_84194007 0.106 ENSMUST00000110294.1
 Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chr2_-_167492826 0.104 ENSMUST00000109211.2
ENSMUST00000057627.9
 Spata2

spermatogenesis associated 2

chr2_-_163417092 0.103 ENSMUST00000127038.1
 Oser1
oxidative stress responsive serine rich 1
chr9_-_22085391 0.099 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
 Ecsit



ECSIT homolog (Drosophila)



chr7_+_45897429 0.094 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr15_-_79141197 0.092 ENSMUST00000169604.1
 1700088E04Rik
RIKEN cDNA 1700088E04 gene
chr14_+_64589802 0.092 ENSMUST00000180610.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr16_-_18248697 0.086 ENSMUST00000115645.3
 Ranbp1
RAN binding protein 1
chr17_+_34605855 0.084 ENSMUST00000037489.8
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr2_-_165283599 0.081 ENSMUST00000155289.1
 Slc35c2
solute carrier family 35, member C2
chr11_+_115475645 0.076 ENSMUST00000035240.6
 Armc7
armadillo repeat containing 7
chr19_-_45998479 0.073 ENSMUST00000045396.7
 9130011E15Rik
RIKEN cDNA 9130011E15 gene
chr4_-_126202757 0.064 ENSMUST00000080919.5
 Thrap3
thyroid hormone receptor associated protein 3
chr2_+_157279026 0.062 ENSMUST00000116380.2
 Rpn2
ribophorin II
chr4_-_129227883 0.059 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr11_+_90638127 0.058 ENSMUST00000020851.8
 Cox11
cytochrome c oxidase assembly protein 11
chr9_-_70141484 0.050 ENSMUST00000034749.8
 Fam81a
family with sequence similarity 81, member A
chr7_-_28598140 0.050 ENSMUST00000108283.1
ENSMUST00000040531.8
 Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr8_+_119862239 0.049 ENSMUST00000034287.8
 Klhl36
kelch-like 36
chr11_+_70657196 0.049 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr7_-_79842287 0.034 ENSMUST00000049004.6
 Anpep
alanyl (membrane) aminopeptidase
chr2_+_157279065 0.033 ENSMUST00000029171.5
 Rpn2
ribophorin II
chr4_+_134397380 0.030 ENSMUST00000105870.1
 Pafah2
platelet-activating factor acetylhydrolase 2
chr8_+_108714644 0.029 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr7_-_79466167 0.026 ENSMUST00000073889.7
 Polg
polymerase (DNA directed), gamma
chr15_+_25773985 0.022 ENSMUST00000125667.1
 Myo10
myosin X
chr4_-_126202583 0.018 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
 Thrap3


thyroid hormone receptor associated protein 3


chrX_-_150589844 0.015 ENSMUST00000112725.1
ENSMUST00000112720.1
 Apex2

apurinic/apyrimidinic endonuclease 2

chr1_+_93215899 0.014 ENSMUST00000138595.1
 E030010N08Rik
RIKEN cDNA E030010N08 gene
chr16_+_10545339 0.013 ENSMUST00000066345.7
ENSMUST00000115824.3
ENSMUST00000155633.1
 Clec16a


C-type lectin domain family 16, member A


chr17_-_73950172 0.006 ENSMUST00000024866.4
 Xdh
xanthine dehydrogenase
chr11_-_3504766 0.006 ENSMUST00000044507.5
 Inpp5j
inositol polyphosphate 5-phosphatase J
chr2_+_69670100 0.006 ENSMUST00000100050.3
 Klhl41
kelch-like 41
chr16_-_20730544 0.001 ENSMUST00000076422.5
 Thpo
thrombopoietin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.3 1.1 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.2 0.7 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.1 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.3 GO:0070375 ERK5 cascade(GO:0070375)
0.1 1.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.3 GO:0032237 activation of store-operated calcium channel activity(GO:0032237)
0.1 0.3 GO:0006842 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746)
0.1 0.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.4 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 0.5 GO:0030432 peristalsis(GO:0030432)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.6 GO:0036376 sodium ion export from cell(GO:0036376)
0.0 0.1 GO:0050787 glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) glyoxal catabolic process(GO:1903190) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) positive regulation of androgen receptor activity(GO:2000825)
0.0 0.2 GO:0033762 response to glucagon(GO:0033762)
0.0 0.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.2 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:0015786 UDP-glucose transport(GO:0015786)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 0.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.2 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.0 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.2 0.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.3 GO:0001847 opsonin receptor activity(GO:0001847)
0.1 0.3 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.1 0.6 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.6 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0044388 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) small protein activating enzyme binding(GO:0044388) cupric ion binding(GO:1903135) cuprous ion binding(GO:1903136) glyoxalase (glycolic acid-forming) activity(GO:1990422)
0.0 0.3 GO:0015288 porin activity(GO:0015288)
0.0 0.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.3 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)