Motif ID: Hoxd12
Z-value: 1.524
Transcription factors associated with Hoxd12:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hoxd12 | ENSMUSG00000001823.4 | Hoxd12 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.5 | 17.0 | GO:0042572 | retinol metabolic process(GO:0042572) |
1.2 | 5.9 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
0.9 | 3.7 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.8 | 5.5 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
0.7 | 2.2 | GO:0036292 | DNA rewinding(GO:0036292) |
0.4 | 3.1 | GO:0016584 | nucleosome positioning(GO:0016584) |
0.4 | 9.2 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
0.4 | 1.2 | GO:0060423 | limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023) negative regulation of mitotic cell cycle, embryonic(GO:0045976) foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901963) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173) |
0.4 | 1.1 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
0.4 | 1.1 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
0.3 | 2.4 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
0.3 | 1.4 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
0.3 | 1.9 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.2 | 1.7 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
0.2 | 0.7 | GO:0046101 | hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) |
0.2 | 3.6 | GO:0035493 | SNARE complex assembly(GO:0035493) |
0.2 | 1.1 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
0.2 | 1.6 | GO:0061042 | vascular wound healing(GO:0061042) |
0.2 | 3.2 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
0.2 | 0.7 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.2 | 5.9 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.1 | 0.7 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
0.1 | 0.4 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.1 | 0.4 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
0.1 | 1.3 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
0.1 | 0.5 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
0.1 | 1.0 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
0.1 | 3.5 | GO:0001706 | endoderm formation(GO:0001706) |
0.1 | 1.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.1 | 0.6 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
0.1 | 0.4 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.1 | 2.1 | GO:0006828 | manganese ion transport(GO:0006828) |
0.1 | 0.3 | GO:0097623 | potassium ion export across plasma membrane(GO:0097623) |
0.1 | 0.5 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.1 | 0.3 | GO:0021546 | rhombomere development(GO:0021546) |
0.1 | 0.9 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
0.1 | 1.7 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
0.1 | 0.7 | GO:0048664 | neuron fate determination(GO:0048664) |
0.1 | 2.4 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
0.1 | 0.3 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
0.1 | 0.4 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
0.1 | 0.2 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
0.1 | 2.1 | GO:0046677 | response to antibiotic(GO:0046677) |
0.1 | 1.2 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
0.1 | 0.1 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
0.0 | 0.8 | GO:0055070 | copper ion homeostasis(GO:0055070) |
0.0 | 1.6 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
0.0 | 1.2 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.0 | 0.4 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.0 | 0.3 | GO:0007379 | segment specification(GO:0007379) |
0.0 | 2.9 | GO:0007601 | visual perception(GO:0007601) |
0.0 | 0.5 | GO:1900153 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153) |
0.0 | 1.2 | GO:0030901 | midbrain development(GO:0030901) |
0.0 | 0.2 | GO:0006527 | arginine catabolic process(GO:0006527) |
0.0 | 1.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 2.7 | GO:0030326 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
0.0 | 0.7 | GO:0045471 | response to ethanol(GO:0045471) |
0.0 | 0.4 | GO:0055010 | ventricular cardiac muscle tissue morphogenesis(GO:0055010) |
0.0 | 0.1 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 3.6 | GO:0070820 | tertiary granule(GO:0070820) |
0.5 | 1.4 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
0.4 | 1.1 | GO:0072534 | perineuronal net(GO:0072534) |
0.3 | 3.0 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.3 | 4.4 | GO:0005922 | connexon complex(GO:0005922) |
0.3 | 1.6 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
0.2 | 3.7 | GO:0043205 | fibril(GO:0043205) |
0.2 | 1.0 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
0.2 | 0.7 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
0.1 | 0.4 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.1 | 1.5 | GO:0030057 | desmosome(GO:0030057) |
0.1 | 0.7 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.1 | 0.3 | GO:0042585 | germinal vesicle(GO:0042585) |
0.1 | 0.5 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.1 | 0.3 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.1 | 1.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.1 | 10.1 | GO:0016605 | PML body(GO:0016605) |
0.1 | 3.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.1 | 8.0 | GO:0016607 | nuclear speck(GO:0016607) |
0.1 | 2.2 | GO:0043596 | nuclear replication fork(GO:0043596) |
0.1 | 5.5 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.0 | 2.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 2.8 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 0.3 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 2.6 | GO:0070469 | respiratory chain(GO:0070469) |
0.0 | 0.6 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.1 | GO:0071942 | XPC complex(GO:0071942) |
0.0 | 1.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 0.2 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.0 | 1.1 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.4 | 17.0 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.7 | 3.7 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.3 | 1.3 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
0.3 | 1.7 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.3 | 5.9 | GO:0032183 | SUMO binding(GO:0032183) |
0.2 | 0.9 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
0.2 | 0.7 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
0.2 | 0.7 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
0.2 | 2.2 | GO:0036310 | annealing helicase activity(GO:0036310) |
0.2 | 2.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.2 | 1.2 | GO:1990188 | euchromatin binding(GO:1990188) |
0.1 | 3.3 | GO:0045295 | gamma-catenin binding(GO:0045295) |
0.1 | 0.5 | GO:0031697 | beta-1 adrenergic receptor binding(GO:0031697) |
0.1 | 1.6 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.1 | 1.7 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.1 | 3.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.1 | 1.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.1 | 0.7 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
0.1 | 3.6 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.1 | 2.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.1 | 6.9 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
0.1 | 3.7 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.1 | 0.8 | GO:0003680 | AT DNA binding(GO:0003680) |
0.1 | 0.2 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.1 | 1.1 | GO:0046625 | sphingolipid binding(GO:0046625) |
0.1 | 0.3 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.1 | 5.9 | GO:0033613 | activating transcription factor binding(GO:0033613) |
0.1 | 0.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
0.1 | 1.2 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
0.1 | 1.1 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
0.0 | 1.0 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
0.0 | 0.2 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
0.0 | 0.4 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.0 | 0.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.0 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.0 | 2.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 2.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
0.0 | 0.2 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.0 | 0.4 | GO:0031489 | myosin V binding(GO:0031489) |
0.0 | 0.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
0.0 | 0.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
0.0 | 0.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.1 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
0.0 | 4.2 | GO:0008134 | transcription factor binding(GO:0008134) |
0.0 | 0.6 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 2.4 | GO:0000287 | magnesium ion binding(GO:0000287) |