Motif ID: Irx6_Irx2_Irx3

Z-value: 0.710

Transcription factors associated with Irx6_Irx2_Irx3:

Gene SymbolEntrez IDGene Name
Irx2 ENSMUSG00000001504.9 Irx2
Irx3 ENSMUSG00000031734.11 Irx3
Irx6 ENSMUSG00000031738.8 Irx6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx2mm10_v2_chr13_+_72628802_72628825-0.411.4e-01Click!
Irx3mm10_v2_chr8_-_91801948_91802067-0.185.3e-01Click!
Irx6mm10_v2_chr8_+_92674826_92674826,
mm10_v2_chr8_+_92674289_92674289		0.126.7e-01Click!


Activity profile for motif Irx6_Irx2_Irx3.

activity profile for motif Irx6_Irx2_Irx3


Sorted Z-values histogram for motif Irx6_Irx2_Irx3

Sorted Z-values for motif Irx6_Irx2_Irx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_17316078 2.535 ENSMUST00000105311.3
 Gm6712
predicted gene 6712
chr7_-_112159034 1.534 ENSMUST00000033036.5
 Dkk3
dickkopf homolog 3 (Xenopus laevis)
chr10_+_61171954 1.383 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr13_+_76579670 1.156 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr18_-_31820413 0.908 ENSMUST00000165131.2
 Gm6665
predicted gene 6665
chr2_-_98667264 0.816 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr11_-_102897123 0.770 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr10_-_125328957 0.706 ENSMUST00000063318.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chrM_+_7759 0.681 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr3_-_87263518 0.646 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr16_+_17146937 0.605 ENSMUST00000115706.1
ENSMUST00000069064.4
 Ydjc

YdjC homolog (bacterial)

chr12_+_52516077 0.578 ENSMUST00000110725.1
 Arhgap5
Rho GTPase activating protein 5
chr5_-_43981757 0.559 ENSMUST00000061299.7
 Fgfbp1
fibroblast growth factor binding protein 1
chr18_-_12819842 0.527 ENSMUST00000119043.1
 Osbpl1a
oxysterol binding protein-like 1A
chr6_+_138140521 0.527 ENSMUST00000120939.1
ENSMUST00000120302.1
 Mgst1

microsomal glutathione S-transferase 1

chr10_-_39122277 0.519 ENSMUST00000136546.1
 Fam229b
family with sequence similarity 229, member B
chr4_-_136898803 0.512 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr7_-_101845300 0.500 ENSMUST00000094141.5
 Folr2
folate receptor 2 (fetal)
chr6_+_149130170 0.498 ENSMUST00000087348.3
 Gm10203
predicted gene 10203
chr19_+_20601958 0.492 ENSMUST00000087638.3
 Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.4 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.2 1.0 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.2 0.7 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 0.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.6 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.6 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.6 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.1 0.5 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.5 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.4 GO:0042435 indole-containing compound biosynthetic process(GO:0042435)
0.0 0.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.4 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.3 GO:0001866 NK T cell proliferation(GO:0001866) regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.1 0.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.3 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.3 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.0 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0061574 ASAP complex(GO:0061574)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.3 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.2 GO:0097361 CIA complex(GO:0097361)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 0.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.7 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.6 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0 0.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.6 GO:0042169 SH2 domain binding(GO:0042169)
0.2 0.5 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.5 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.3 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.1 0.3 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.2 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.1 0.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)