Motif ID: Pitx3

Z-value: 0.873


Transcription factors associated with Pitx3:

Gene SymbolEntrez IDGene Name
Pitx3 ENSMUSG00000025229.9 Pitx3



Activity profile for motif Pitx3.

activity profile for motif Pitx3


Sorted Z-values histogram for motif Pitx3

Sorted Z-values for motif Pitx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_62899118 2.604 ENSMUST00000174189.1
 Tet1
tet methylcytosine dioxygenase 1
chr16_+_17276291 2.011 ENSMUST00000164950.1
ENSMUST00000159242.1
 Tmem191c

transmembrane protein 191C

chr9_+_22454290 1.986 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr8_-_72213636 1.512 ENSMUST00000109987.1
 Gm11034
predicted gene 11034
chr7_+_18987518 1.389 ENSMUST00000063563.7
 Nanos2
nanos homolog 2 (Drosophila)
chr8_+_65967157 1.237 ENSMUST00000072482.6
 March1
membrane-associated ring finger (C3HC4) 1
chr2_-_73312701 1.037 ENSMUST00000058615.9
 Cir1
corepressor interacting with RBPJ, 1
chr9_+_118506226 1.022 ENSMUST00000084820.4
 Golga4
golgi autoantigen, golgin subfamily a, 4
chr10_-_62792243 1.002 ENSMUST00000020268.5
 Ccar1
cell division cycle and apoptosis regulator 1
chrX_-_37104523 0.994 ENSMUST00000130324.1
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr16_+_17276337 0.914 ENSMUST00000159065.1
ENSMUST00000159494.1
ENSMUST00000159811.1
 Tmem191c


transmembrane protein 191C


chrX_-_103623648 0.911 ENSMUST00000156211.1
 Ftx
Ftx transcript, Xist regulator (non-protein coding)
chrX_+_142226765 0.906 ENSMUST00000112916.2
 Nxt2
nuclear transport factor 2-like export factor 2
chr11_-_62457772 0.895 ENSMUST00000127471.2
 Ncor1
nuclear receptor co-repressor 1
chr11_-_115133981 0.889 ENSMUST00000106561.1
ENSMUST00000051264.7
ENSMUST00000106562.2
 Cd300lf


CD300 antigen like family member F


chr4_-_86612009 0.877 ENSMUST00000125481.1
ENSMUST00000070607.7
 Haus6

HAUS augmin-like complex, subunit 6

chr9_-_15357692 0.837 ENSMUST00000098979.3
ENSMUST00000161132.1
 5830418K08Rik

RIKEN cDNA 5830418K08 gene

chr2_+_127008711 0.831 ENSMUST00000110394.1
ENSMUST00000002063.8
 Ap4e1

adaptor-related protein complex AP-4, epsilon 1

chr3_-_152340350 0.820 ENSMUST00000073089.6
ENSMUST00000068243.6
 Fam73a

family with sequence similarity 73, member A

chrX_-_36645359 0.806 ENSMUST00000051906.6
 Akap17b
A kinase (PRKA) anchor protein 17B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.6 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.4 1.7 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.3 1.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.3 1.5 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.3 1.4 GO:0044838 cell quiescence(GO:0044838)
0.0 1.3 GO:0006986 response to unfolded protein(GO:0006986)
0.3 1.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 1.2 GO:0001824 blastocyst development(GO:0001824)
0.1 1.0 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 0.9 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.3 0.8 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.0 0.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.8 GO:0031297 replication fork processing(GO:0031297)
0.2 0.7 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.1 0.7 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.7 GO:0003383 apical constriction(GO:0003383)
0.1 0.7 GO:0036297 interstrand cross-link repair(GO:0036297)
0.2 0.6 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.2 0.6 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 0.6 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0005802 trans-Golgi network(GO:0005802)
0.6 1.7 GO:0000802 transverse filament(GO:0000802)
0.0 1.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.9 GO:0070652 HAUS complex(GO:0070652)
0.1 0.9 GO:0042555 MCM complex(GO:0042555)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.9 GO:0043596 nuclear replication fork(GO:0043596)
0.2 0.8 GO:0031230 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
0.2 0.7 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 0.7 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.7 GO:0033269 internode region of axon(GO:0033269)
0.1 0.6 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 0.5 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 0.5 GO:0070938 contractile ring(GO:0070938)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.4 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.6 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.4 1.7 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 1.2 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.9 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.2 0.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 0.8 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)
0.1 0.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.7 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.1 0.6 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.6 GO:0043559 insulin binding(GO:0043559)
0.0 0.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.6 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.4 GO:0031871 proteinase activated receptor binding(GO:0031871)