Motif ID: Smad1

Z-value: 1.802


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.352.2e-01Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 4.842 ENSMUST00000075312.3
 Ttr
transthyretin
chrX_+_73483602 3.984 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr1_-_171234290 3.185 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr2_-_25470031 2.847 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr3_+_94693556 1.981 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr7_-_142576492 1.930 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA
chr6_+_55336424 1.615 ENSMUST00000004774.3
 Aqp1
aquaporin 1
chr8_+_119666498 1.570 ENSMUST00000024107.5
 Wfdc1
WAP four-disulfide core domain 1
chr11_-_55419898 1.568 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr11_+_101448403 1.437 ENSMUST00000010502.6
 Ifi35
interferon-induced protein 35
chr2_-_25469742 1.404 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr11_-_50238480 1.399 ENSMUST00000102772.3
ENSMUST00000125555.1
 Ltc4s

leukotriene C4 synthase

chr4_+_148160613 1.357 ENSMUST00000047951.8
 Fbxo2
F-box protein 2
chr11_+_32296489 1.333 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr4_-_136886187 1.330 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr10_-_117282262 1.328 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr17_-_35175995 1.313 ENSMUST00000173324.1
 Aif1
allograft inflammatory factor 1
chr6_+_121300227 1.306 ENSMUST00000064580.7
 Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr2_-_33942111 1.186 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr11_-_102897123 1.183 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 651 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.0 4.9 GO:0070327 thyroid hormone transport(GO:0070327)
1.4 4.1 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.3 2.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.9 2.8 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.4 2.8 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.1 2.7 GO:0030199 collagen fibril organization(GO:0030199)
0.2 2.6 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.2 2.4 GO:0018149 peptide cross-linking(GO:0018149)
0.8 2.3 GO:0015889 cobalamin transport(GO:0015889)
0.2 2.3 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 2.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.6 2.2 GO:0071280 cellular response to copper ion(GO:0071280)
0.7 2.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.7 2.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.2 2.1 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.1 2.1 GO:0010595 positive regulation of endothelial cell migration(GO:0010595)
0.4 2.0 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.2 2.0 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.2 2.0 GO:0006958 complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 240 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.8 GO:0005615 extracellular space(GO:0005615)
0.1 10.6 GO:0072562 blood microparticle(GO:0072562)
0.0 8.2 GO:0031012 extracellular matrix(GO:0031012)
0.1 6.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.8 GO:0005925 focal adhesion(GO:0005925)
0.8 3.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 3.0 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 2.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 2.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.5 2.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 2.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 2.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 2.1 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)
0.0 1.9 GO:0005844 polysome(GO:0005844)
0.0 1.8 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0008180 COP9 signalosome(GO:0008180)
0.4 1.6 GO:0032127 dense core granule membrane(GO:0032127)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 415 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 5.7 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 5.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 5.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 5.2 GO:0004364 glutathione transferase activity(GO:0004364)
1.2 4.9 GO:0019763 immunoglobulin receptor activity(GO:0019763)
1.2 4.8 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 3.8 GO:0008430 selenium binding(GO:0008430)
0.8 3.1 GO:0031720 haptoglobin binding(GO:0031720)
0.7 2.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 2.7 GO:0001848 complement binding(GO:0001848)
0.0 2.7 GO:0005178 integrin binding(GO:0005178)
0.0 2.7 GO:0008201 heparin binding(GO:0008201)
0.6 2.5 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.1 2.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 2.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 2.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 2.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 2.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 2.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)