Motif ID: E2f4

Z-value: 1.094


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.156.0e-01Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 154 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_53638945 2.826 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)
chr15_+_57912199 2.414 ENSMUST00000022992.6
 Tbc1d31
TBC1 domain family, member 31
chrY_-_90754821 2.364 ENSMUST00000177893.1
 Gm21860
predicted gene, 21860
chrY_+_90784738 2.355 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1
chr2_-_172940299 2.278 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr17_+_86753900 2.267 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr12_+_76533540 2.235 ENSMUST00000075249.4
 Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chrX_+_170009892 2.197 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr1_-_189688074 2.096 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr17_-_28350747 2.070 ENSMUST00000080572.7
ENSMUST00000156862.1
 Tead3

TEA domain family member 3

chr19_+_6084983 2.030 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr11_-_101551837 1.951 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr15_-_76639840 1.799 ENSMUST00000166974.1
ENSMUST00000168185.1
 Tonsl

tonsoku-like, DNA repair protein

chr7_+_126781483 1.793 ENSMUST00000172352.1
ENSMUST00000094037.4
 Tbx6

T-box 6

chr17_-_28350600 1.784 ENSMUST00000114799.1
 Tead3
TEA domain family member 3
chr2_+_125136692 1.711 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr9_-_82975475 1.689 ENSMUST00000034787.5
 Phip
pleckstrin homology domain interacting protein
chr17_-_25727364 1.665 ENSMUST00000170070.1
ENSMUST00000048054.7
 Chtf18

CTF18, chromosome transmission fidelity factor 18

chr13_+_23535411 1.547 ENSMUST00000080859.5
 Hist1h3g
histone cluster 1, H3g
chr5_-_112228934 1.546 ENSMUST00000181535.2
 Miat
myocardial infarction associated transcript (non-protein coding)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.1 3.4 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.2 3.0 GO:0070986 left/right axis specification(GO:0070986)
0.1 2.9 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 2.8 GO:0006284 base-excision repair(GO:0006284)
0.1 2.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.8 2.3 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.6 2.3 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.2 2.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 2.1 GO:0051310 metaphase plate congression(GO:0051310)
0.7 2.0 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.7 2.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.4 1.8 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.1 1.8 GO:0031297 replication fork processing(GO:0031297)
0.2 1.7 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 1.7 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.4 1.6 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990) negative regulation of t-circle formation(GO:1904430)
0.3 1.5 GO:0036233 glycine import(GO:0036233)
0.0 1.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5 1.4 GO:0000087 mitotic M phase(GO:0000087)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.2 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.4 2.6 GO:0031262 Ndc80 complex(GO:0031262)
0.2 2.6 GO:0042555 MCM complex(GO:0042555)
0.2 2.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 2.0 GO:0008278 cohesin complex(GO:0008278)
0.2 2.0 GO:0070531 BRCA1-A complex(GO:0070531)
0.2 1.7 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 1.5 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 1.4 GO:0031523 Myb complex(GO:0031523)
0.0 1.4 GO:0000922 spindle pole(GO:0000922)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.2 1.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.8 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.8 GO:0000795 synaptonemal complex(GO:0000795)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0042393 histone binding(GO:0042393)
0.1 2.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 2.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.6 2.8 GO:0000405 bubble DNA binding(GO:0000405)
0.2 2.3 GO:0070700 BMP receptor binding(GO:0070700)
0.2 2.3 GO:0050897 cobalt ion binding(GO:0050897)
0.0 2.1 GO:0045502 dynein binding(GO:0045502)
0.1 1.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 1.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.3 1.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 1.5 GO:0003684 damaged DNA binding(GO:0003684)
0.2 1.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.4 GO:0050699 WW domain binding(GO:0050699)
0.3 1.1 GO:0042731 PH domain binding(GO:0042731)
0.0 1.1 GO:0005112 Notch binding(GO:0005112)
0.0 1.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 0.9 GO:0009982 pseudouridine synthase activity(GO:0009982)