Motif ID: Smad3

Z-value: 0.478


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_63757994-0.479.4e-02Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_23531044 1.072 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr13_-_21832194 0.953 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr12_+_119945957 0.907 ENSMUST00000058644.8
 Tmem196
transmembrane protein 196
chrX_-_7188713 0.797 ENSMUST00000004428.7
 Clcn5
chloride channel 5
chr2_-_148408146 0.734 ENSMUST00000099270.3
 Thbd
thrombomodulin
chr7_+_51880312 0.714 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chr15_+_81936753 0.690 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr6_+_116650674 0.625 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr19_-_47919269 0.623 ENSMUST00000095998.5
 Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr5_-_116422858 0.585 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr11_-_116110211 0.574 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr2_+_29869484 0.552 ENSMUST00000047521.6
ENSMUST00000134152.1
 Cercam

cerebral endothelial cell adhesion molecule

chr7_+_82867327 0.548 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr13_+_23581563 0.504 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chrX_+_10485121 0.501 ENSMUST00000076354.6
ENSMUST00000115526.1
 Tspan7

tetraspanin 7

chr14_-_62456286 0.472 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr2_-_26640230 0.431 ENSMUST00000181621.1
ENSMUST00000180659.1
 Snhg7

small nucleolar RNA host gene (non-protein coding) 7

chr17_-_31277327 0.404 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr13_-_23551648 0.395 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr14_+_64589802 0.389 ENSMUST00000180610.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr11_-_103344651 0.388 ENSMUST00000041385.7
 Arhgap27
Rho GTPase activating protein 27
chr15_+_81936911 0.382 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chrX_-_95026671 0.346 ENSMUST00000096367.3
 Spin4
spindlin family, member 4
chr17_-_6827990 0.306 ENSMUST00000181895.1
 Gm2885
predicted gene 2885
chr9_+_69454066 0.287 ENSMUST00000134907.1
 Anxa2
annexin A2
chr13_+_23746734 0.285 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr7_-_81454751 0.281 ENSMUST00000098331.3
ENSMUST00000178892.1
 Cpeb1

cytoplasmic polyadenylation element binding protein 1

chr1_+_172341197 0.279 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr7_-_100964371 0.269 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_-_75210732 0.266 ENSMUST00000113623.1
 Glb1l
galactosidase, beta 1-like
chr10_+_33905015 0.265 ENSMUST00000169670.1
 Rsph4a
radial spoke head 4 homolog A (Chlamydomonas)
chr13_+_21735055 0.265 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr2_-_29869785 0.263 ENSMUST00000047607.1
 2600006K01Rik
RIKEN cDNA 2600006K01 gene
chr6_-_36811361 0.259 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr19_+_5740885 0.259 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr18_-_74207771 0.249 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr9_-_45936049 0.247 ENSMUST00000034590.2
 Tagln
transgelin
chr2_-_104257400 0.247 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr17_-_27623441 0.245 ENSMUST00000025050.5
 Nudt3
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr13_+_23533869 0.244 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr1_-_21079162 0.200 ENSMUST00000037998.4
 Tram2
translocating chain-associating membrane protein 2
chr13_+_92354783 0.191 ENSMUST00000022218.4
 Dhfr
dihydrofolate reductase
chr7_-_127588595 0.184 ENSMUST00000072155.3
 Gm166
predicted gene 166
chr3_-_107760221 0.181 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr12_+_100779074 0.168 ENSMUST00000110073.1
ENSMUST00000110070.1
 9030617O03Rik

RIKEN cDNA 9030617O03 gene

chr13_-_21750505 0.162 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr1_+_146497614 0.159 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr14_+_119138415 0.155 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr15_-_81697256 0.149 ENSMUST00000072910.5
 Chadl
chondroadherin-like
chr3_+_107631322 0.146 ENSMUST00000106703.1
 Gm10961
predicted gene 10961
chr4_+_140986873 0.144 ENSMUST00000168047.1
ENSMUST00000037055.7
ENSMUST00000127833.2
 Atp13a2


ATPase type 13A2


chr11_-_79254663 0.137 ENSMUST00000017821.5
 Wsb1
WD repeat and SOCS box-containing 1
chr13_-_23571151 0.131 ENSMUST00000102969.3
 Hist1h2ae
histone cluster 1, H2ae
chr2_-_30194112 0.119 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr13_+_21833736 0.110 ENSMUST00000180288.1
ENSMUST00000110467.1
 Hist1h2br

histone cluster 1 H2br

chr15_-_76209056 0.101 ENSMUST00000071869.5
ENSMUST00000170915.1
 Plec

plectin

chr10_+_79854658 0.097 ENSMUST00000171599.1
ENSMUST00000095457.4
 Ptbp1

polypyrimidine tract binding protein 1

chr7_-_44236098 0.097 ENSMUST00000037220.4
 1700028J19Rik
RIKEN cDNA 1700028J19 gene
chr12_+_12911986 0.086 ENSMUST00000085720.1
 Rpl36-ps3
ribosomal protein L36, pseudogene 3
chr13_-_21833575 0.084 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr11_-_102447647 0.082 ENSMUST00000049057.4
 Fam171a2
family with sequence similarity 171, member A2
chr10_+_79854618 0.082 ENSMUST00000165704.1
 Ptbp1
polypyrimidine tract binding protein 1
chr7_-_45052865 0.077 ENSMUST00000057293.6
 Prr12
proline rich 12
chr19_+_55898553 0.075 ENSMUST00000148666.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr17_-_27623263 0.074 ENSMUST00000062397.6
ENSMUST00000176876.1
 Nudt3

nudix (nucleotide diphosphate linked moiety X)-type motif 3

chr14_+_32028989 0.069 ENSMUST00000022460.4
 Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr13_+_23571382 0.065 ENSMUST00000079251.5
 Hist1h2bg
histone cluster 1, H2bg
chrX_-_150814265 0.065 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
 Maged2


melanoma antigen, family D, 2


chr13_+_22043189 0.065 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr13_+_22035821 0.062 ENSMUST00000110455.2
 Hist1h2bk
histone cluster 1, H2bk
chr5_+_145204523 0.059 ENSMUST00000085671.3
ENSMUST00000031601.7
 Zkscan5

zinc finger with KRAB and SCAN domains 5

chr6_-_72235559 0.052 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr13_-_22042949 0.051 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chrX_+_105079761 0.047 ENSMUST00000119477.1
 Pbdc1
polysaccharide biosynthesis domain containing 1
chr13_+_21810428 0.045 ENSMUST00000091745.5
 Hist1h2ao
histone cluster 1, H2ao
chr1_-_143702832 0.040 ENSMUST00000018337.7
 Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component
chr13_-_21810190 0.039 ENSMUST00000110469.1
ENSMUST00000091749.2
 Hist1h2bq

histone cluster 1, H2bq

chr10_-_120979327 0.039 ENSMUST00000119944.1
ENSMUST00000119093.1
 Lemd3

LEM domain containing 3

chr13_-_21787218 0.038 ENSMUST00000091751.2
 Hist1h2an
histone cluster 1, H2an
chr7_+_44384803 0.030 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr1_+_75210832 0.022 ENSMUST00000027401.4
ENSMUST00000144355.1
ENSMUST00000123825.1
 Stk16


serine/threonine kinase 16


chr5_-_53707532 0.016 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr4_+_151089570 0.015 ENSMUST00000105667.2
 Gm13090
predicted gene 13090
chr13_-_22035589 0.011 ENSMUST00000091742.4
 Hist1h2ah
histone cluster 1, H2ah
chr7_+_104857009 0.007 ENSMUST00000067695.7
 Usp17la
ubiquitin specific peptidase 17-like A
chr9_-_20879718 0.003 ENSMUST00000043726.6
 Angptl6
angiopoietin-like 6
chr18_+_60526194 0.003 ENSMUST00000025505.5
 Dctn4
dynactin 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.5 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 0.3 GO:0071544 diphosphoinositol polyphosphate metabolic process(GO:0071543) diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.1 0.3 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.3 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 0.3 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.1 0.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.1 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.3 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.0 0.2 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039) peptidyl-aspartic acid modification(GO:0018197)
0.0 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.3 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0 0.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.5 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.6 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.6 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 0.7 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.2 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.3 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.1 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.0 3.2 GO:0042393 histone binding(GO:0042393)
0.0 0.3 GO:0050431 transforming growth factor beta binding(GO:0050431)