Motif ID: Smad3

Z-value: 0.478


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_63757994-0.479.4e-02Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 87 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_23531044 1.072 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr13_-_21832194 0.953 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr12_+_119945957 0.907 ENSMUST00000058644.8
 Tmem196
transmembrane protein 196
chrX_-_7188713 0.797 ENSMUST00000004428.7
 Clcn5
chloride channel 5
chr2_-_148408146 0.734 ENSMUST00000099270.3
 Thbd
thrombomodulin
chr7_+_51880312 0.714 ENSMUST00000145049.1
 Gas2
growth arrest specific 2
chr15_+_81936753 0.690 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr6_+_116650674 0.625 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr19_-_47919269 0.623 ENSMUST00000095998.5
 Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr5_-_116422858 0.585 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr11_-_116110211 0.574 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr2_+_29869484 0.552 ENSMUST00000047521.6
ENSMUST00000134152.1
 Cercam

cerebral endothelial cell adhesion molecule

chr7_+_82867327 0.548 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr13_+_23581563 0.504 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chrX_+_10485121 0.501 ENSMUST00000076354.6
ENSMUST00000115526.1
 Tspan7

tetraspanin 7

chr14_-_62456286 0.472 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr2_-_26640230 0.431 ENSMUST00000181621.1
ENSMUST00000180659.1
 Snhg7

small nucleolar RNA host gene (non-protein coding) 7

chr17_-_31277327 0.404 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr13_-_23551648 0.395 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr14_+_64589802 0.389 ENSMUST00000180610.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.7 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.6 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.6 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.5 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.5 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 0.3 GO:0071544 diphosphoinositol polyphosphate metabolic process(GO:0071543) diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.1 0.3 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.3 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 0.3 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 0.3 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.0 0.3 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.1 0.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.2 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
0.0 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.2 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 0.1 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0000786 nucleosome(GO:0000786)
0.1 0.7 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.3 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.3 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0042393 histone binding(GO:0042393)
0.0 0.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.3 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.2 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.2 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)