Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.443

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2



Activity profile for motif Nkx1-1_Nkx1-2.

activity profile for motif Nkx1-1_Nkx1-2


Sorted Z-values histogram for motif Nkx1-1_Nkx1-2

Sorted Z-values for motif Nkx1-1_Nkx1-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_102906046 0.970 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102905740 0.764 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_55782500 0.753 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr11_+_43682038 0.717 ENSMUST00000094294.4
 Pwwp2a
PWWP domain containing 2A
chr3_+_121953213 0.681 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr10_+_128337761 0.661 ENSMUST00000005826.7
 Cs
citrate synthase
chr16_+_52031549 0.612 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr4_+_102570065 0.609 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr7_-_73537621 0.543 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chrX_-_60893430 0.522 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr8_+_113635550 0.516 ENSMUST00000179926.1
 Mon1b
MON1 homolog b (yeast)
chr17_-_63863791 0.510 ENSMUST00000050753.3
 A930002H24Rik
RIKEN cDNA A930002H24 gene
chr8_+_113635787 0.508 ENSMUST00000035777.8
 Mon1b
MON1 homolog b (yeast)
chr5_+_37185897 0.427 ENSMUST00000094840.3
 Gm1043
predicted gene 1043
chr7_+_128744870 0.425 ENSMUST00000042942.8
 Sec23ip
Sec23 interacting protein
chr11_+_43681998 0.415 ENSMUST00000061070.5
 Pwwp2a
PWWP domain containing 2A
chrX_-_74085656 0.391 ENSMUST00000033770.6
 Mecp2
methyl CpG binding protein 2
chr12_-_25096080 0.391 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr2_-_102400257 0.364 ENSMUST00000152929.1
 Trim44
tripartite motif-containing 44
chr14_-_5863663 0.356 ENSMUST00000178594.1
 Gm8237
predicted gene 8237
chr1_-_91459254 0.336 ENSMUST00000069620.8
 Per2
period circadian clock 2
chr4_-_132075250 0.305 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chr7_+_24271568 0.301 ENSMUST00000032696.6
 Zfp93
zinc finger protein 93
chr14_-_52104015 0.284 ENSMUST00000111610.4
ENSMUST00000164655.1
 Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr19_+_8802486 0.283 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3
chr4_-_14621494 0.282 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr2_-_45112890 0.274 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr4_-_14621669 0.269 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr7_+_29983948 0.268 ENSMUST00000148442.1
 Zfp568
zinc finger protein 568
chr8_-_34965631 0.267 ENSMUST00000033929.4
 Tnks
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr7_-_143460989 0.262 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr11_+_121237216 0.257 ENSMUST00000103015.3
 Narf
nuclear prelamin A recognition factor
chr19_+_29367447 0.253 ENSMUST00000016640.7
 Cd274
CD274 antigen
chr8_-_3694167 0.251 ENSMUST00000005678.4
 Fcer2a
Fc receptor, IgE, low affinity II, alpha polypeptide
chr9_-_107872403 0.244 ENSMUST00000183035.1
 Rbm6
RNA binding motif protein 6
chr2_-_69712461 0.243 ENSMUST00000102706.3
ENSMUST00000073152.6
 Fastkd1

FAST kinase domains 1

chr5_+_138116903 0.231 ENSMUST00000062350.8
ENSMUST00000110961.2
ENSMUST00000080732.3
ENSMUST00000110960.2
ENSMUST00000142185.1
ENSMUST00000136425.1
ENSMUST00000110959.1
 Zscan21






zinc finger and SCAN domain containing 21






chr5_-_74531619 0.230 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
 Scfd2



Sec1 family domain containing 2



chrX_-_74085586 0.199 ENSMUST00000123362.1
ENSMUST00000140399.1
ENSMUST00000100750.3
 Mecp2


methyl CpG binding protein 2


chr11_+_21572221 0.198 ENSMUST00000020568.3
ENSMUST00000131135.1
 Wdpcp

WD repeat containing planar cell polarity effector

chr2_-_37703845 0.196 ENSMUST00000155237.1
 Strbp
spermatid perinuclear RNA binding protein
chr1_-_172027269 0.195 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr18_-_24603464 0.189 ENSMUST00000154205.1
 Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr1_+_174501796 0.189 ENSMUST00000030039.7
 Fmn2
formin 2
chr18_+_24603952 0.188 ENSMUST00000025120.6
 Elp2
elongator acetyltransferase complex subunit 2
chr11_-_21371143 0.188 ENSMUST00000060895.5
 Ugp2
UDP-glucose pyrophosphorylase 2
chr2_-_165388245 0.183 ENSMUST00000103084.3
 Zfp334
zinc finger protein 334
chr5_+_138187485 0.179 ENSMUST00000110934.2
 Cnpy4
canopy 4 homolog (zebrafish)
chr18_-_24603791 0.169 ENSMUST00000070726.3
 Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr17_-_57031468 0.165 ENSMUST00000007814.8
 Khsrp
KH-type splicing regulatory protein
chr12_+_4769278 0.162 ENSMUST00000020967.4
 Pfn4
profilin family, member 4
chr7_-_44929410 0.159 ENSMUST00000107857.3
ENSMUST00000085399.6
ENSMUST00000167930.1
ENSMUST00000166972.1
 Ap2a1



adaptor-related protein complex 2, alpha 1 subunit



chr12_+_52699297 0.151 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr12_+_4769375 0.151 ENSMUST00000178879.1
 Pfn4
profilin family, member 4
chr11_+_87109221 0.146 ENSMUST00000020794.5
 Ska2
spindle and kinetochore associated complex subunit 2
chr12_+_84417196 0.141 ENSMUST00000183146.1
 Rnf113a2
ring finger protein 113A2
chr5_+_118245226 0.139 ENSMUST00000049138.7
 2410131K14Rik
RIKEN cDNA 2410131K14 gene
chr15_+_98092569 0.125 ENSMUST00000163507.1
 Pfkm
phosphofructokinase, muscle
chr19_+_11965817 0.122 ENSMUST00000025590.9
 Osbp
oxysterol binding protein
chr5_-_84417359 0.122 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr7_-_30552255 0.121 ENSMUST00000108165.1
ENSMUST00000153594.1
 BC053749

cDNA sequence BC053749

chr9_-_85749308 0.121 ENSMUST00000039213.8
 Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr14_+_4198185 0.120 ENSMUST00000180184.1
 Gm2974
predicted gene 2974
chrX_-_160138375 0.118 ENSMUST00000033662.8
 Pdha1
pyruvate dehydrogenase E1 alpha 1
chr5_+_143909964 0.114 ENSMUST00000148011.1
ENSMUST00000110709.3
 Pms2

postmeiotic segregation increased 2 (S. cerevisiae)

chr8_-_86580664 0.113 ENSMUST00000131423.1
ENSMUST00000152438.1
 Abcc12

ATP-binding cassette, sub-family C (CFTR/MRP), member 12

chr9_-_20959785 0.113 ENSMUST00000177754.1
 Dnmt1
DNA methyltransferase (cytosine-5) 1
chr4_-_132463873 0.098 ENSMUST00000102567.3
 Med18
mediator of RNA polymerase II transcription, subunit 18 homolog (yeast)
chr4_-_14621805 0.095 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr9_-_66126559 0.092 ENSMUST00000137542.1
 Snx1
sorting nexin 1
chrX_+_107255878 0.088 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
 Gpr174


G protein-coupled receptor 174


chr2_-_132247747 0.086 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
 Tmem230


transmembrane protein 230


chr7_-_27195727 0.084 ENSMUST00000163311.2
ENSMUST00000126211.1
 Snrpa

small nuclear ribonucleoprotein polypeptide A

chr11_-_99230998 0.083 ENSMUST00000103133.3
 Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr15_+_81663889 0.078 ENSMUST00000023029.8
ENSMUST00000174229.1
ENSMUST00000172748.1
 L3mbtl2


l(3)mbt-like 2 (Drosophila)


chr14_-_6266620 0.076 ENSMUST00000096172.5
 Gm3411
predicted gene 3411
chr19_-_29367294 0.072 ENSMUST00000138051.1
 Plgrkt
plasminogen receptor, C-terminal lysine transmembrane protein
chr5_+_115605642 0.061 ENSMUST00000094427.3
 Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr4_-_119294520 0.060 ENSMUST00000079644.6
 Ybx1
Y box protein 1
chr7_+_27195781 0.057 ENSMUST00000108379.1
ENSMUST00000179391.1
 BC024978

cDNA sequence BC024978

chr5_-_118244861 0.057 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr11_-_43747963 0.056 ENSMUST00000048578.2
ENSMUST00000109278.1
 Ttc1

tetratricopeptide repeat domain 1

chr15_+_41830921 0.055 ENSMUST00000166917.1
 Oxr1
oxidation resistance 1
chr7_-_38019505 0.051 ENSMUST00000085513.4
 Uri1
URI1, prefoldin-like chaperone
chr8_+_83972951 0.047 ENSMUST00000005606.6
 Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr3_-_89101907 0.046 ENSMUST00000081848.8
 Fdps
farnesyl diphosphate synthetase
chr12_-_4769217 0.043 ENSMUST00000053458.5
 Fam228b
family with sequence similarity 228, member B
chr12_+_111039334 0.039 ENSMUST00000084968.7
 Rcor1
REST corepressor 1
chr6_+_145934113 0.033 ENSMUST00000032383.7
 Sspn
sarcospan
chr6_+_37870786 0.028 ENSMUST00000120428.1
ENSMUST00000031859.7
 Trim24

tripartite motif-containing 24

chr5_+_9100681 0.028 ENSMUST00000115365.1
 Tmem243
transmembrane protein 243, mitochondrial
chr10_+_94575257 0.020 ENSMUST00000121471.1
 Tmcc3
transmembrane and coiled coil domains 3
chr10_+_88146992 0.020 ENSMUST00000052355.7
 Nup37
nucleoporin 37
chr5_-_34660068 0.013 ENSMUST00000041364.9
 Nop14
NOP14 nucleolar protein
chr18_+_4993795 0.012 ENSMUST00000153016.1
 Svil
supervillin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0019085 early viral transcription(GO:0019085)
0.2 0.6 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.2 0.6 GO:0009405 pathogenesis(GO:0009405)
0.1 0.5 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.6 GO:0019532 oxalate transport(GO:0019532)
0.1 0.3 GO:1904742 protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742)
0.1 0.3 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.1 0.4 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.3 GO:0090365 regulation of mRNA modification(GO:0090365)
0.1 0.2 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)
0.1 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.6 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:1903056 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.3 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.2 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.5 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.4 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.3 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.5 GO:0007530 sex determination(GO:0007530)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.0 0.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.0 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.2 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.1 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.3 GO:0060065 uterus development(GO:0060065)
0.0 0.1 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0044447 axoneme part(GO:0044447)
0.0 0.3 GO:0045120 telomerase holoenzyme complex(GO:0005697) pronucleus(GO:0045120)
0.0 0.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0071204 CRD-mediated mRNA stability complex(GO:0070937) histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.1 0.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.3 GO:0019863 IgE binding(GO:0019863)
0.1 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.6 GO:0030552 cAMP binding(GO:0030552)
0.0 0.1 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.0 GO:0004337 geranyltranstransferase activity(GO:0004337)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.3 GO:0003785 actin monomer binding(GO:0003785)