Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.443

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2



Activity profile for motif Nkx1-1_Nkx1-2.

activity profile for motif Nkx1-1_Nkx1-2


Sorted Z-values histogram for motif Nkx1-1_Nkx1-2

Sorted Z-values for motif Nkx1-1_Nkx1-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_102906046 0.970 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102905740 0.764 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr3_+_55782500 0.753 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr11_+_43682038 0.717 ENSMUST00000094294.4
 Pwwp2a
PWWP domain containing 2A
chr3_+_121953213 0.681 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr10_+_128337761 0.661 ENSMUST00000005826.7
 Cs
citrate synthase
chr16_+_52031549 0.612 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr4_+_102570065 0.609 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr7_-_73537621 0.543 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chrX_-_60893430 0.522 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr8_+_113635550 0.516 ENSMUST00000179926.1
 Mon1b
MON1 homolog b (yeast)
chr17_-_63863791 0.510 ENSMUST00000050753.3
 A930002H24Rik
RIKEN cDNA A930002H24 gene
chr8_+_113635787 0.508 ENSMUST00000035777.8
 Mon1b
MON1 homolog b (yeast)
chr5_+_37185897 0.427 ENSMUST00000094840.3
 Gm1043
predicted gene 1043
chr7_+_128744870 0.425 ENSMUST00000042942.8
 Sec23ip
Sec23 interacting protein
chr11_+_43681998 0.415 ENSMUST00000061070.5
 Pwwp2a
PWWP domain containing 2A
chrX_-_74085656 0.391 ENSMUST00000033770.6
 Mecp2
methyl CpG binding protein 2
chr12_-_25096080 0.391 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr2_-_102400257 0.364 ENSMUST00000152929.1
 Trim44
tripartite motif-containing 44
chr14_-_5863663 0.356 ENSMUST00000178594.1
 Gm8237
predicted gene 8237

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.0 GO:0019085 early viral transcription(GO:0019085)
0.0 0.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.2 0.6 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.2 0.6 GO:0009405 pathogenesis(GO:0009405)
0.1 0.6 GO:0019532 oxalate transport(GO:0019532)
0.0 0.6 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.5 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.5 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.5 GO:0007530 sex determination(GO:0007530)
0.1 0.4 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.4 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.3 GO:1904742 protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742)
0.1 0.3 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.1 0.3 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.3 GO:1903056 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.3 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.3 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.3 GO:0060065 uterus development(GO:0060065)
0.1 0.2 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.3 GO:0045120 telomerase holoenzyme complex(GO:0005697) pronucleus(GO:0045120)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0044447 axoneme part(GO:0044447)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:0071204 CRD-mediated mRNA stability complex(GO:0070937) histone pre-mRNA 3'end processing complex(GO:0071204)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.6 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.1 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.6 GO:0030552 cAMP binding(GO:0030552)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0019863 IgE binding(GO:0019863)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)