Motif ID: Runx1
Z-value: 0.913
Transcription factors associated with Runx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Runx1 | ENSMUSG00000022952.10 | Runx1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.5 | 5.3 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.4 | 4.0 | GO:0043615 | astrocyte cell migration(GO:0043615) |
| 0.4 | 1.2 | GO:0010752 | signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752) |
| 0.3 | 1.0 | GO:0050929 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.3 | 3.1 | GO:0033280 | response to vitamin D(GO:0033280) |
| 0.3 | 2.1 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.2 | 1.1 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.2 | 1.9 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.2 | 5.9 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.2 | 1.0 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.2 | 1.1 | GO:0051461 | regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 0.1 | 0.4 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 0.1 | 0.7 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 0.4 | GO:0032829 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) negative regulation of interleukin-2 biosynthetic process(GO:0045085) negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.1 | 0.6 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.1 | 0.4 | GO:0045472 | response to ether(GO:0045472) |
| 0.1 | 0.8 | GO:0002681 | somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) |
| 0.1 | 0.5 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.1 | 2.0 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 0.4 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
| 0.1 | 0.3 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
| 0.1 | 0.2 | GO:2000813 | negative regulation of barbed-end actin filament capping(GO:2000813) |
| 0.1 | 0.2 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.1 | 0.2 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
| 0.0 | 0.2 | GO:2001274 | negative regulation of glucose import in response to insulin stimulus(GO:2001274) |
| 0.0 | 0.4 | GO:0002903 | negative regulation of B cell apoptotic process(GO:0002903) |
| 0.0 | 0.2 | GO:0035752 | lysosomal lumen pH elevation(GO:0035752) |
| 0.0 | 0.3 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.0 | 0.3 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.9 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.2 | GO:0061101 | neuroendocrine cell differentiation(GO:0061101) |
| 0.0 | 0.3 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.0 | 0.3 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.0 | 0.1 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.0 | 0.1 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.0 | 1.6 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 1.1 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 0.4 | GO:0006767 | water-soluble vitamin metabolic process(GO:0006767) |
| 0.0 | 0.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 0.5 | GO:0035066 | positive regulation of histone acetylation(GO:0035066) |
| 0.0 | 0.1 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.0 | 0.1 | GO:0046036 | GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036) |
| 0.0 | 0.2 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.0 | 0.3 | GO:0034724 | DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.1 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.1 | 1.2 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 0.6 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.4 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 1.0 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 4.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 3.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 1.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.8 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.1 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 0.1 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.0 | 0.2 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.0 | 1.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 3.2 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.0 | 0.1 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.0 | 1.9 | GO:0030027 | lamellipodium(GO:0030027) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 0.5 | 1.9 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.2 | 1.1 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.2 | 0.6 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.2 | 4.4 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.2 | 2.1 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 1.2 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 4.0 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 1.0 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.1 | 0.7 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 0.9 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 1.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 3.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.4 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.1 | 0.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 0.3 | GO:0004999 | vasoactive intestinal polypeptide receptor activity(GO:0004999) |
| 0.1 | 0.4 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 0.6 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 2.1 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 5.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.4 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 2.0 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 0.1 | GO:0047760 | butyrate-CoA ligase activity(GO:0047760) |
| 0.0 | 0.3 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.3 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.0 | 0.1 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 1.7 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.3 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 0.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.2 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 0.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.1 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.0 | 0.4 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 0.4 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.1 | GO:0042610 | CD8 receptor binding(GO:0042610) |
