Motif ID: Runx1

Z-value: 0.913


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_42907563 4.691 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr11_-_83649349 3.954 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr12_-_34528844 3.485 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr5_+_104435112 3.139 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr13_+_76579670 2.700 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr8_+_76902277 2.040 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr13_+_49608030 1.928 ENSMUST00000021822.5
 Ogn
osteoglycin
chr6_+_17491216 1.864 ENSMUST00000080469.5
 Met
met proto-oncogene
chr1_-_140183404 1.652 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr1_-_140183283 1.475 ENSMUST00000111977.1
 Cfh
complement component factor h
chrX_-_57338598 1.424 ENSMUST00000033468.4
ENSMUST00000114736.1
 Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr7_-_90129339 1.339 ENSMUST00000181189.1
 2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr15_+_62037986 1.267 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
 Pvt1




plasmacytoma variant translocation 1




chr16_+_43510267 1.211 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr15_+_9436028 1.192 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr14_-_66280949 1.184 ENSMUST00000111121.1
ENSMUST00000022622.7
ENSMUST00000089250.2
 Ptk2b


PTK2 protein tyrosine kinase 2 beta


chr11_-_79530569 1.179 ENSMUST00000103236.3
ENSMUST00000170799.1
ENSMUST00000170422.2
 Evi2a

Evi2b
ecotropic viral integration site 2a

ecotropic viral integration site 2b
chr3_-_88296979 1.135 ENSMUST00000107556.3
 Tsacc
TSSK6 activating co-chaperone
chr17_-_90455872 1.104 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr2_-_116065798 1.100 ENSMUST00000110907.1
ENSMUST00000110908.2
 Meis2

Meis homeobox 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.5 5.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.4 4.0 GO:0043615 astrocyte cell migration(GO:0043615)
0.5 3.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 3.1 GO:0033280 response to vitamin D(GO:0033280)
0.3 2.1 GO:0019532 oxalate transport(GO:0019532)
0.1 2.0 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.2 1.9 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 1.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 1.2 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
0.2 1.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.2 1.1 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 1.1 GO:0008542 visual learning(GO:0008542)
0.3 1.0 GO:0050929 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.2 1.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.8 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 0.7 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.6 GO:0007386 compartment pattern specification(GO:0007386)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.2 GO:0072562 blood microparticle(GO:0072562)
0.0 3.2 GO:0045177 apical part of cell(GO:0045177)
0.0 2.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.9 GO:0030027 lamellipodium(GO:0030027)
0.0 1.5 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 1.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.0 GO:0010369 chromocenter(GO:0010369)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.6 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 0.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 4.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 4.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 3.6 GO:0050840 extracellular matrix binding(GO:0050840)
1.0 3.1 GO:0001851 complement component C3b binding(GO:0001851)
0.2 2.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 2.1 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 2.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.5 1.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 1.7 GO:0008083 growth factor activity(GO:0008083)
0.1 1.2 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 1.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 1.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.0 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.7 GO:0043426 MRF binding(GO:0043426)
0.2 0.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)