Motif ID: Spi1

Z-value: 0.742


Transcription factors associated with Spi1:

Gene SymbolEntrez IDGene Name
Spi1 ENSMUSG00000002111.8 Spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spi1mm10_v2_chr2_+_91082362_91082390-0.431.3e-01Click!


Activity profile for motif Spi1.

activity profile for motif Spi1


Sorted Z-values histogram for motif Spi1

Sorted Z-values for motif Spi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Spi1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_57113053 1.690 ENSMUST00000112627.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr18_-_66860458 1.511 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr11_-_95514570 1.327 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr7_+_123982799 0.982 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr10_-_64090241 0.879 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr9_-_16378231 0.833 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr19_-_14597983 0.794 ENSMUST00000052011.7
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr10_-_64090265 0.786 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr17_+_80944611 0.779 ENSMUST00000025092.4
 Tmem178
transmembrane protein 178
chr1_+_153665666 0.754 ENSMUST00000111814.1
ENSMUST00000111810.1
 Rgs8

regulator of G-protein signaling 8

chr17_+_31433054 0.728 ENSMUST00000136384.1
 Pde9a
phosphodiesterase 9A
chr6_+_15185456 0.722 ENSMUST00000115472.1
ENSMUST00000115474.1
ENSMUST00000031545.7
ENSMUST00000137628.1
 Foxp2



forkhead box P2



chr5_+_32136458 0.699 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr11_-_7213897 0.694 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr1_+_152399824 0.692 ENSMUST00000044311.8
 Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr6_-_23248264 0.679 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_+_103313806 0.679 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr8_-_122699066 0.670 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chrX_-_52165252 0.665 ENSMUST00000033450.2
 Gpc4
glypican 4
chr14_-_102982630 0.643 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 449 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.2 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.2 2.0 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 1.7 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 1.7 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.1 1.5 GO:0010842 retina layer formation(GO:0010842)
0.1 1.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 1.2 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 1.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 1.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.3 0.9 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.9 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.9 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 0.8 GO:0070488 neutrophil aggregation(GO:0070488)
0.0 0.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.2 0.7 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.2 0.7 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.1 0.7 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.1 0.7 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.7 GO:1903715 regulation of aerobic respiration(GO:1903715)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.0 GO:0043198 dendritic shaft(GO:0043198)
0.2 0.7 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1 0.7 GO:0008623 CHRAC(GO:0008623)
0.0 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.1 0.6 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.6 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.5 GO:0031430 M band(GO:0031430)
0.0 0.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.4 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.4 GO:0000444 MIS12/MIND type complex(GO:0000444)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 275 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.1 1.9 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 1.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 1.4 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 1.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 1.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.9 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 0.9 GO:0045296 cadherin binding(GO:0045296)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.9 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.9 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 0.8 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.7 GO:0045503 dynein light chain binding(GO:0045503)
0.1 0.7 GO:0072542 protein phosphatase activator activity(GO:0072542)