Motif ID: Tgif2_Tgif2lx1_Tgif2lx2

Z-value: 1.048

Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:

Gene SymbolEntrez IDGene Name
Tgif2 ENSMUSG00000062175.7 Tgif2
Tgif2lx1 ENSMUSG00000061283.4 Tgif2lx1
Tgif2lx2 ENSMUSG00000063242.6 Tgif2lx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif2mm10_v2_chr2_+_156840077_1568401410.391.7e-01Click!


Activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2.

activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2


Sorted Z-values histogram for motif Tgif2_Tgif2lx1_Tgif2lx2

Sorted Z-values for motif Tgif2_Tgif2lx1_Tgif2lx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 169 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_86753900 5.184 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr2_+_105675478 3.075 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr5_-_45857473 2.933 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
 Lcorl


ligand dependent nuclear receptor corepressor-like


chr15_+_85510812 2.832 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr2_+_105675429 2.773 ENSMUST00000111085.1
 Pax6
paired box gene 6
chr7_+_51621830 2.346 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr14_-_31019055 1.862 ENSMUST00000037739.6
 Gnl3
guanine nucleotide binding protein-like 3 (nucleolar)
chr1_+_19103022 1.706 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr2_-_165473187 1.629 ENSMUST00000029208.8
ENSMUST00000109279.2
 Slc13a3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr7_-_44670820 1.603 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr11_-_87108656 1.563 ENSMUST00000051395.8
 Prr11
proline rich 11
chr1_-_93343482 1.553 ENSMUST00000128253.1
 Pask
PAS domain containing serine/threonine kinase
chr14_-_70653081 1.548 ENSMUST00000062629.4
 Npm2
nucleophosmin/nucleoplasmin 2
chr9_+_44134562 1.535 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr3_+_102010138 1.521 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr17_-_36989504 1.502 ENSMUST00000169189.1
 H2-M5
histocompatibility 2, M region locus 5
chr2_-_27246814 1.366 ENSMUST00000149733.1
 Sardh
sarcosine dehydrogenase
chrY_+_90755657 1.284 ENSMUST00000167967.2
 Gm21857
predicted gene, 21857
chr5_-_115119277 1.151 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr3_-_107969162 1.091 ENSMUST00000004136.8
ENSMUST00000106678.1
 Gstm3

glutathione S-transferase, mu 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 5.8 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
1.3 5.2 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.1 2.3 GO:0001504 neurotransmitter uptake(GO:0001504)
0.1 1.9 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.1 1.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 1.7 GO:0030901 midbrain development(GO:0030901)
0.4 1.6 GO:0006842 tricarboxylic acid transport(GO:0006842) succinate transport(GO:0015744) citrate transport(GO:0015746)
0.2 1.6 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 1.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 1.5 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 1.5 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.5 GO:0042698 ovulation cycle(GO:0042698)
0.1 1.4 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 1.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 1.2 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 1.1 GO:0030224 monocyte differentiation(GO:0030224)
0.0 1.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.3 1.0 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.2 1.0 GO:0034421 post-translational protein acetylation(GO:0034421)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.2 GO:0016607 nuclear speck(GO:0016607)
0.0 1.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 1.6 GO:0097513 myosin II filament(GO:0097513)
0.1 1.3 GO:0000124 SAGA complex(GO:0000124)
0.0 1.1 GO:0005795 Golgi stack(GO:0005795)
0.1 1.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.0 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.9 GO:0097546 ciliary base(GO:0097546)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.7 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.5 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.8 GO:0003680 AT DNA binding(GO:0003680)
0.4 5.2 GO:0050897 cobalt ion binding(GO:0050897)
0.1 2.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.5 1.6 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.1 1.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.5 GO:0042605 peptide antigen binding(GO:0042605)
0.0 1.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 1.4 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 1.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.2 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.2 1.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 1.1 GO:0005272 sodium channel activity(GO:0005272)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.3 1.0 GO:0004568 chitinase activity(GO:0004568)
0.1 1.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.7 GO:0005179 hormone activity(GO:0005179)