Motif ID: Mecom

Z-value: 1.028


Transcription factors associated with Mecom:

Gene SymbolEntrez IDGene Name
Mecom ENSMUSG00000027684.10 Mecom



Activity profile for motif Mecom.

activity profile for motif Mecom


Sorted Z-values histogram for motif Mecom

Sorted Z-values for motif Mecom



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecom

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 15.243 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr1_+_152399824 4.240 ENSMUST00000044311.8
 Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr7_-_103853199 1.567 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr10_-_6980376 1.474 ENSMUST00000105617.1
 Ipcef1
interaction protein for cytohesin exchange factors 1
chr5_+_66259890 1.449 ENSMUST00000065530.6
 Nsun7
NOL1/NOP2/Sun domain family, member 7
chr1_+_185454803 1.288 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr14_+_34375504 1.185 ENSMUST00000111908.1
 Mmrn2
multimerin 2
chr6_+_138140298 1.056 ENSMUST00000008684.4
 Mgst1
microsomal glutathione S-transferase 1
chr14_-_52020698 0.883 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chrX_+_112604274 0.841 ENSMUST00000071814.6
 Zfp711
zinc finger protein 711
chr11_-_115367667 0.810 ENSMUST00000123428.1
ENSMUST00000044152.6
ENSMUST00000106542.2
 Hid1


HID1 domain containing


chr1_+_45311538 0.806 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr4_+_133039482 0.797 ENSMUST00000105914.1
 Ahdc1
AT hook, DNA binding motif, containing 1
chr15_-_48791933 0.699 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
 Csmd3


CUB and Sushi multiple domains 3


chrX_-_37110257 0.643 ENSMUST00000076265.6
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chrX_-_113185485 0.636 ENSMUST00000026607.8
ENSMUST00000113388.2
 Chm

choroidermia

chr3_+_36552600 0.548 ENSMUST00000029269.5
ENSMUST00000136890.1
 Exosc9

exosome component 9

chr1_+_156838915 0.465 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr4_-_110292719 0.443 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_+_11704439 0.395 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr9_-_13245741 0.381 ENSMUST00000110582.2
 Jrkl
jerky homolog-like (mouse)
chr5_+_65131184 0.328 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr4_+_128846163 0.326 ENSMUST00000138291.1
 Gm12968
predicted gene 12968
chr6_+_113392417 0.321 ENSMUST00000032414.4
ENSMUST00000038889.5
 Ttll3

tubulin tyrosine ligase-like family, member 3

chr9_+_115909455 0.318 ENSMUST00000119291.1
ENSMUST00000069651.6
 Gadl1

glutamate decarboxylase-like 1

chr13_+_89540636 0.303 ENSMUST00000022108.7
 Hapln1
hyaluronan and proteoglycan link protein 1
chr2_-_149798701 0.301 ENSMUST00000148202.1
ENSMUST00000139471.1
 Gm14133

predicted gene 14133

chr2_+_97467657 0.288 ENSMUST00000059049.7
 Lrrc4c
leucine rich repeat containing 4C
chr18_+_4994600 0.286 ENSMUST00000140448.1
 Svil
supervillin
chrX_+_9885622 0.242 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr6_+_96113146 0.222 ENSMUST00000122120.1
 Fam19a1
family with sequence similarity 19, member A1
chr5_+_34525797 0.221 ENSMUST00000125817.1
ENSMUST00000067638.7
 Sh3bp2

SH3-domain binding protein 2

chr10_+_3740348 0.203 ENSMUST00000120274.1
 Plekhg1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr5_+_134582690 0.194 ENSMUST00000023867.6
 Rfc2
replication factor C (activator 1) 2
chr10_+_5593718 0.192 ENSMUST00000051809.8
 Myct1
myc target 1
chr3_+_41742615 0.174 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr9_+_72806874 0.160 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr13_-_103764502 0.158 ENSMUST00000074616.5
 Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr9_+_105053239 0.149 ENSMUST00000035177.8
ENSMUST00000149243.1
 Mrpl3

mitochondrial ribosomal protein L3

chrX_-_88760312 0.128 ENSMUST00000182943.1
 Gm27000
predicted gene, 27000
chr5_-_120467296 0.117 ENSMUST00000132916.1
 Sdsl
serine dehydratase-like
chr9_+_64235201 0.111 ENSMUST00000039011.3
 Uchl4
ubiquitin carboxyl-terminal esterase L4
chr7_+_82337218 0.103 ENSMUST00000173828.1
 Adamtsl3
ADAMTS-like 3
chr14_+_61599493 0.103 ENSMUST00000039562.6
 Trim13
tripartite motif-containing 13
chr13_+_49544443 0.098 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr5_+_129715488 0.092 ENSMUST00000119576.1
ENSMUST00000042191.5
ENSMUST00000118420.1
ENSMUST00000154358.1
ENSMUST00000121339.1
ENSMUST00000119604.1
ENSMUST00000136108.1
ENSMUST00000121813.1
ENSMUST00000119985.1
ENSMUST00000138812.1
 Mrps17









mitochondrial ribosomal protein S17









chr1_+_107511489 0.090 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr12_-_86079019 0.088 ENSMUST00000003687.6
 Tgfb3
transforming growth factor, beta 3
chr4_+_41569775 0.074 ENSMUST00000102963.3
 Dnaic1
dynein, axonemal, intermediate chain 1
chr2_+_18672384 0.060 ENSMUST00000171845.1
ENSMUST00000061158.4
 Commd3

COMM domain containing 3

chr5_-_136198908 0.053 ENSMUST00000149151.1
ENSMUST00000151786.1
 Prkrip1

Prkr interacting protein 1 (IL11 inducible)

chr18_-_43477764 0.042 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr9_+_65890237 0.036 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr9_+_44398176 0.029 ENSMUST00000165839.1
 Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr10_-_80701811 0.018 ENSMUST00000003438.9
 Mob3a
MOB kinase activator 3A
chr1_+_107511416 0.013 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr16_-_38713235 0.012 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr18_+_80206887 0.009 ENSMUST00000127234.1
 Gm16286
predicted gene 16286
chr13_+_21495218 0.005 ENSMUST00000104942.1
 AK157302
cDNA sequence AK157302
chr1_-_69685937 0.005 ENSMUST00000027146.2
 Ikzf2
IKAROS family zinc finger 2
chr2_-_152830266 0.004 ENSMUST00000140436.1
 Bcl2l1
BCL2-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 15.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 1.6 GO:0015671 oxygen transport(GO:0015671)
0.3 1.1 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.2 1.4 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.2 0.5 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.2 0.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 1.3 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.3 GO:0018094 protein polyglycylation(GO:0018094)
0.1 1.2 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1 0.6 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0003032 detection of oxygen(GO:0003032) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.0 0.8 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.2 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0005833 hemoglobin complex(GO:0005833)
0.2 0.8 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 0.6 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.4 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 15.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.4 1.6 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 4.2 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.4 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)