Motif ID: Nfat5

Z-value: 0.790


Transcription factors associated with Nfat5:

Gene SymbolEntrez IDGene Name
Nfat5 ENSMUSG00000003847.10 Nfat5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293463_1072934830.401.6e-01Click!


Activity profile for motif Nfat5.

activity profile for motif Nfat5


Sorted Z-values histogram for motif Nfat5

Sorted Z-values for motif Nfat5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfat5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_144209558 2.442 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209471 2.413 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209448 2.393 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr10_-_29535857 2.036 ENSMUST00000092623.3
 Rspo3
R-spondin 3 homolog (Xenopus laevis)
chr2_+_172549581 1.514 ENSMUST00000030391.2
 Tfap2c
transcription factor AP-2, gamma
chr10_-_95415484 1.272 ENSMUST00000172070.1
ENSMUST00000150432.1
 Socs2

suppressor of cytokine signaling 2

chr4_-_82505749 1.128 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr10_-_95415283 1.121 ENSMUST00000119917.1
 Socs2
suppressor of cytokine signaling 2
chr2_+_68117713 1.106 ENSMUST00000112346.2
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr4_-_82505707 1.019 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr3_-_129755305 0.935 ENSMUST00000029653.2
 Egf
epidermal growth factor
chr6_-_58907120 0.934 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr5_-_124354671 0.618 ENSMUST00000031341.4
 Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr13_+_44840686 0.598 ENSMUST00000173906.1
 Jarid2
jumonji, AT rich interactive domain 2
chr6_-_101377897 0.588 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr8_+_86745679 0.567 ENSMUST00000098532.2
 Gm10638
predicted gene 10638
chr5_-_66618772 0.560 ENSMUST00000162994.1
ENSMUST00000159512.1
ENSMUST00000159786.1
 Apbb2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr15_-_38078842 0.501 ENSMUST00000110336.2
 Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr16_-_55838827 0.460 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr9_-_13446753 0.448 ENSMUST00000167906.2
 Gm17571
predicted gene, 17571
chr11_+_119022962 0.378 ENSMUST00000026662.7
 Cbx2
chromobox 2
chr6_+_91684061 0.322 ENSMUST00000032185.7
 Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr7_+_46847128 0.321 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chrX_+_123793665 0.317 ENSMUST00000178148.1
 Gm5167
predicted gene 5167
chr10_+_4611971 0.307 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr4_+_110397661 0.303 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr5_-_66618636 0.297 ENSMUST00000162382.1
ENSMUST00000160870.1
ENSMUST00000087256.5
ENSMUST00000160103.1
ENSMUST00000162349.1
 Apbb2




amyloid beta (A4) precursor protein-binding, family B, member 2




chrX_+_74429671 0.282 ENSMUST00000114127.1
ENSMUST00000064407.3
ENSMUST00000156707.1
 Ikbkg


inhibitor of kappaB kinase gamma


chr9_-_105521147 0.273 ENSMUST00000176770.1
ENSMUST00000085133.6
 Atp2c1

ATPase, Ca++-sequestering

chr12_+_102948843 0.268 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr19_+_25236959 0.258 ENSMUST00000049400.8
 Kank1
KN motif and ankyrin repeat domains 1
chr18_+_36559972 0.252 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr9_-_7835255 0.252 ENSMUST00000074246.6
 Birc2
baculoviral IAP repeat-containing 2
chr5_-_66618752 0.240 ENSMUST00000162366.1
 Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr12_-_83597140 0.231 ENSMUST00000048319.4
 Zfyve1
zinc finger, FYVE domain containing 1
chr9_+_92457369 0.223 ENSMUST00000034941.7
 Plscr4
phospholipid scramblase 4
chr5_-_104021919 0.217 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr18_+_36560581 0.211 ENSMUST00000155329.2
 Ankhd1
ankyrin repeat and KH domain containing 1
chr5_+_120511213 0.211 ENSMUST00000111890.2
ENSMUST00000076051.5
ENSMUST00000147496.1
 Slc8b1


solute carrier family 8 (sodium/lithium/calcium exchanger), member B1


chr15_-_75894474 0.204 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr11_-_70656467 0.199 ENSMUST00000131642.1
 Gm12319
predicted gene 12319
chr2_-_30415302 0.198 ENSMUST00000132981.2
ENSMUST00000129494.1
 Crat

carnitine acetyltransferase

chr5_-_66451629 0.179 ENSMUST00000160063.1
 Apbb2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr4_+_110397764 0.178 ENSMUST00000097920.2
ENSMUST00000080744.6
 Agbl4

ATP/GTP binding protein-like 4

chr3_-_98724543 0.171 ENSMUST00000107022.1
ENSMUST00000107021.1
 Hsd3b2

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

chr10_+_84622365 0.156 ENSMUST00000077175.5
 Polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr11_-_77725281 0.149 ENSMUST00000078623.4
 Cryba1
crystallin, beta A1
chr17_+_43389436 0.143 ENSMUST00000113599.1
 Gpr116
G protein-coupled receptor 116
chr6_-_142964404 0.142 ENSMUST00000032421.3
 St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chrX_+_139684980 0.140 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr12_+_84417196 0.139 ENSMUST00000183146.1
 Rnf113a2
ring finger protein 113A2
chr18_-_43477764 0.130 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr5_+_139423151 0.118 ENSMUST00000066211.4
 Gper1
G protein-coupled estrogen receptor 1
chr12_+_98920567 0.116 ENSMUST00000085109.3
ENSMUST00000079146.6
 Ttc8

tetratricopeptide repeat domain 8

chr19_-_10525201 0.109 ENSMUST00000025570.6
 Sdhaf2
succinate dehydrogenase complex assembly factor 2
chr2_-_30415389 0.109 ENSMUST00000142096.1
 Crat
carnitine acetyltransferase
chr9_+_7764041 0.109 ENSMUST00000052865.9
 Tmem123
transmembrane protein 123
chr5_-_27501362 0.109 ENSMUST00000155721.1
ENSMUST00000053257.3
 Speer4b

spermatogenesis associated glutamate (E)-rich protein 4b

chr15_-_52478228 0.103 ENSMUST00000081993.1
 Gm10020
predicted pseudogene 10020
chr14_+_8080315 0.102 ENSMUST00000023924.3
 Rpp14
ribonuclease P 14 subunit
chr4_-_135573623 0.101 ENSMUST00000105855.1
 Grhl3
grainyhead-like 3 (Drosophila)
chr11_+_120491840 0.097 ENSMUST00000026899.3
 Slc25a10
solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
chr16_-_16600533 0.096 ENSMUST00000159542.1
 Fgd4
FYVE, RhoGEF and PH domain containing 4
chr5_-_104021799 0.091 ENSMUST00000119025.1
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr15_-_98881255 0.081 ENSMUST00000024518.9
 Rhebl1
Ras homolog enriched in brain like 1
chr8_+_125730005 0.080 ENSMUST00000143504.1
 Ntpcr
nucleoside-triphosphatase, cancer-related
chr13_+_73626886 0.078 ENSMUST00000022104.7
 Tert
telomerase reverse transcriptase
chr7_-_46958475 0.066 ENSMUST00000094398.4
 Uevld
UEV and lactate/malate dehyrogenase domains
chr4_+_141444654 0.065 ENSMUST00000006377.6
 Zbtb17
zinc finger and BTB domain containing 17
chr5_+_120511168 0.062 ENSMUST00000068326.7
 Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr1_+_83159733 0.060 ENSMUST00000113436.1
ENSMUST00000065436.3
ENSMUST00000065403.6
 Daw1


dynein assembly factor with WDR repeat domains 1


chr6_-_92183972 0.058 ENSMUST00000140438.1
 Mrps25
mitochondrial ribosomal protein S25
chr7_+_99535439 0.056 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chrX_-_49797700 0.050 ENSMUST00000033442.7
ENSMUST00000114891.1
 Igsf1

immunoglobulin superfamily, member 1

chr2_+_176831140 0.047 ENSMUST00000122218.2
ENSMUST00000126726.1
 Gm14408

predicted gene 14408

chr14_-_55116935 0.045 ENSMUST00000022819.5
 Jph4
junctophilin 4
chr7_+_99535652 0.044 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr9_-_71771535 0.040 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
 Cgnl1


cingulin-like 1


chr7_-_81493883 0.031 ENSMUST00000082090.7
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr17_+_87107621 0.030 ENSMUST00000041369.6
 Socs5
suppressor of cytokine signaling 5
chr12_-_40248073 0.023 ENSMUST00000169926.1
 Ifrd1
interferon-related developmental regulator 1
chr6_+_73248382 0.020 ENSMUST00000064740.6
 Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
chr14_-_23803304 0.020 ENSMUST00000179836.1
ENSMUST00000172099.2
ENSMUST00000065788.8
ENSMUST00000179097.1
ENSMUST00000177634.1
ENSMUST00000074983.6
ENSMUST00000163322.2
ENSMUST00000100831.4
 Kcnma1







potassium large conductance calcium-activated channel, subfamily M, alpha member 1







chr15_+_5185700 0.014 ENSMUST00000081640.5
 Ttc33
tetratricopeptide repeat domain 33
chr4_+_3940747 0.009 ENSMUST00000119403.1
 Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr3_-_27710413 0.005 ENSMUST00000046157.4
 Fndc3b
fibronectin type III domain containing 3B
chr2_-_30415509 0.003 ENSMUST00000134120.1
ENSMUST00000102854.3
 Crat

carnitine acetyltransferase

chr14_-_16575456 0.001 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 7.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.5 2.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.5 1.5 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 0.9 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.2 0.5 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 2.0 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 0.3 GO:1900044 regulation of protein K63-linked ubiquitination(GO:1900044)
0.1 2.4 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 0.5 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.3 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 1.1 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.3 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.1 0.3 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 0.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.3 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.1 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0 0.3 GO:0042447 hormone catabolic process(GO:0042447)
0.0 0.1 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.3 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.0 0.1 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.1 GO:0015744 succinate transport(GO:0015744)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.0 0.1 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 0.1 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.1 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.3 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.6 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.1 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.1 GO:0030035 microspike assembly(GO:0030035)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 7.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0044327 dendritic spine membrane(GO:0032591) dendritic spine head(GO:0044327)
0.0 0.1 GO:0034464 BBSome(GO:0034464)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 1.1 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.1 0.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.3 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 0.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.3 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 0.3 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 0.3 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 2.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 2.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.0 1.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 1.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 7.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)