Motif ID: Hoxd11_Cdx1_Hoxc11

Z-value: 0.876

Transcription factors associated with Hoxd11_Cdx1_Hoxc11:

Gene SymbolEntrez IDGene Name
Cdx1 ENSMUSG00000024619.8 Cdx1
Hoxc11 ENSMUSG00000001656.3 Hoxc11
Hoxd11 ENSMUSG00000042499.12 Hoxd11



Activity profile for motif Hoxd11_Cdx1_Hoxc11.

activity profile for motif Hoxd11_Cdx1_Hoxc11


Sorted Z-values histogram for motif Hoxd11_Cdx1_Hoxc11

Sorted Z-values for motif Hoxd11_Cdx1_Hoxc11



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_144209558 5.307 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209448 5.250 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr6_-_144209471 5.160 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr15_+_25773985 3.230 ENSMUST00000125667.1
 Myo10
myosin X
chr17_+_31433054 1.788 ENSMUST00000136384.1
 Pde9a
phosphodiesterase 9A
chr18_-_62741387 1.488 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr6_+_15196949 1.167 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr10_+_116177351 1.167 ENSMUST00000155606.1
ENSMUST00000128399.1
 Ptprr

protein tyrosine phosphatase, receptor type, R

chr17_+_3397189 1.131 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr19_+_24875679 1.124 ENSMUST00000073080.5
 Gm10053
predicted gene 10053
chr18_-_42899470 1.114 ENSMUST00000120632.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr3_+_103575275 1.053 ENSMUST00000090697.4
 Syt6
synaptotagmin VI
chr6_+_80018877 1.026 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4



chr3_+_103575231 0.992 ENSMUST00000121834.1
 Syt6
synaptotagmin VI
chrX_+_96455359 0.889 ENSMUST00000033553.7
 Heph
hephaestin
chr7_-_73537621 0.870 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr9_-_21067093 0.854 ENSMUST00000115494.2
 Zglp1
zinc finger, GATA-like protein 1
chr1_-_163289214 0.731 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr5_-_25100624 0.730 ENSMUST00000030784.7
 Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr1_-_172027251 0.723 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 16.2 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 3.4 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.7 2.0 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 1.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 1.6 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.3 1.5 GO:0060467 negative regulation of fertilization(GO:0060467)
0.3 1.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 1.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 1.1 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.1 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.0 GO:1901629 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) regulation of presynaptic membrane organization(GO:1901629)
0.0 1.0 GO:0015813 L-glutamate transport(GO:0015813)
0.1 0.9 GO:0007320 insemination(GO:0007320)
0.1 0.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.9 GO:0006825 copper ion transport(GO:0006825)
0.0 0.9 GO:0048599 oocyte development(GO:0048599)
0.0 0.8 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.2 0.7 GO:0007210 serotonin receptor signaling pathway(GO:0007210)
0.1 0.7 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.7 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.3 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 3.9 GO:0016459 myosin complex(GO:0016459)
0.0 2.0 GO:0043204 perikaryon(GO:0043204)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 1.1 GO:0060187 cell pole(GO:0060187)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.7 GO:0070852 cell body fiber(GO:0070852)
0.0 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.6 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.6 GO:1990391 DNA repair complex(GO:1990391)
0.1 0.5 GO:1990357 terminal web(GO:1990357)
0.1 0.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.3 GO:0097440 apical dendrite(GO:0097440)
0.0 0.3 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 3.4 GO:0030507 spectrin binding(GO:0030507)
0.0 2.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.9 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 1.6 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.0 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 0.9 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.8 GO:0045499 chemorepellent activity(GO:0045499)
0.2 0.7 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 0.7 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin binding(GO:0051378) serotonin receptor activity(GO:0099589)
0.1 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.7 GO:0071837 HMG box domain binding(GO:0071837)
0.2 0.6 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.2 0.6 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.6 GO:0030552 cAMP binding(GO:0030552)
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)