Motif ID: Dlx5_Dlx4

Z-value: 1.876

Transcription factors associated with Dlx5_Dlx4:

Gene SymbolEntrez IDGene Name
Dlx4 ENSMUSG00000020871.7 Dlx4
Dlx5 ENSMUSG00000029755.9 Dlx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx5mm10_v2_chr6_-_6882068_6882092-0.742.3e-03Click!


Activity profile for motif Dlx5_Dlx4.

activity profile for motif Dlx5_Dlx4


Sorted Z-values histogram for motif Dlx5_Dlx4

Sorted Z-values for motif Dlx5_Dlx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx5_Dlx4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_34904913 9.944 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr19_-_19001099 8.533 ENSMUST00000040153.8
ENSMUST00000112828.1
 Rorb

RAR-related orphan receptor beta

chr9_-_16378231 8.113 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr16_+_52031549 5.386 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr5_-_84417359 4.069 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr12_-_55014329 3.690 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr15_+_7129557 3.424 ENSMUST00000067190.5
ENSMUST00000164529.1
 Lifr

leukemia inhibitory factor receptor

chr3_+_103575275 3.383 ENSMUST00000090697.4
 Syt6
synaptotagmin VI
chr4_+_102570065 3.058 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr13_-_89742244 3.022 ENSMUST00000109543.2
ENSMUST00000159337.1
ENSMUST00000159910.1
ENSMUST00000109544.2
 Vcan



versican



chr11_+_71749914 2.993 ENSMUST00000150531.1
 Wscd1
WSC domain containing 1
chr14_-_16249154 2.856 ENSMUST00000148121.1
ENSMUST00000112624.1
 Oxsm

3-oxoacyl-ACP synthase, mitochondrial

chr3_+_103575231 2.771 ENSMUST00000121834.1
 Syt6
synaptotagmin VI
chrX_-_166585679 2.548 ENSMUST00000000412.2
 Egfl6
EGF-like-domain, multiple 6
chr13_-_89742490 2.505 ENSMUST00000109546.2
 Vcan
versican
chr4_-_132075250 2.494 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chr8_+_3353415 2.454 ENSMUST00000098966.3
 A430078G23Rik
RIKEN cDNA A430078G23 gene
chr4_-_123664725 2.392 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1
chr9_+_27299205 2.266 ENSMUST00000115247.1
ENSMUST00000133213.1
 Igsf9b

immunoglobulin superfamily, member 9B

chr2_-_121235689 2.256 ENSMUST00000142400.1
 Trp53bp1
transformation related protein 53 binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 10.3 GO:0046549 retinal cone cell development(GO:0046549)
2.0 9.9 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.3 8.2 GO:0010842 retina layer formation(GO:0010842)
2.1 6.2 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 5.9 GO:0008347 glial cell migration(GO:0008347)
1.8 5.4 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.4 4.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
1.1 3.4 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 3.4 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.2 3.1 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 3.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.8 3.0 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 3.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 2.9 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.2 2.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 2.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 2.8 GO:0043062 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.9 2.7 GO:0019085 early viral transcription(GO:0019085)
0.0 2.5 GO:0007266 Rho protein signal transduction(GO:0007266)
0.3 2.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.9 GO:0043198 dendritic shaft(GO:0043198)
0.0 10.7 GO:0030425 dendrite(GO:0030425)
0.4 9.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 5.9 GO:0005938 cell cortex(GO:0005938)
0.0 5.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 5.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 4.8 GO:0043034 costamere(GO:0043034)
0.1 4.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.7 3.7 GO:0008623 CHRAC(GO:0008623)
0.1 3.4 GO:0031672 A band(GO:0031672)
0.1 3.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 3.0 GO:0043195 terminal bouton(GO:0043195)
0.0 2.7 GO:0043235 receptor complex(GO:0043235)
0.6 2.4 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 2.2 GO:0060077 inhibitory synapse(GO:0060077)
0.0 2.1 GO:0030018 Z disc(GO:0030018)
0.2 2.0 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.2 1.9 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 1.7 GO:0001741 XY body(GO:0001741)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 11.1 GO:0003779 actin binding(GO:0003779)
3.4 10.3 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 6.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 5.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 5.5 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.2 5.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.5 4.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 3.7 GO:0061659 ubiquitin-like protein ligase activity(GO:0061659)
1.1 3.4 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924)
1.0 3.0 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.7 2.9 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.1 2.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 2.9 GO:0019208 phosphatase regulator activity(GO:0019208)
0.2 2.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 2.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 2.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.5 2.3 GO:0070330 aromatase activity(GO:0070330)
0.1 2.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.3 2.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)