Motif ID: Hif1a

Z-value: 1.022


Transcription factors associated with Hif1a:

Gene SymbolEntrez IDGene Name
Hif1a ENSMUSG00000021109.7 Hif1a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hif1amm10_v2_chr12_+_73901370_73901391-0.431.2e-01Click!


Activity profile for motif Hif1a.

activity profile for motif Hif1a


Sorted Z-values histogram for motif Hif1a

Sorted Z-values for motif Hif1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hif1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_45999860 2.025 ENSMUST00000053558.9
 Ankrd37
ankyrin repeat domain 37
chr7_+_46845832 1.702 ENSMUST00000048209.9
ENSMUST00000092621.4
 Ldha

lactate dehydrogenase A

chr19_-_44069690 1.293 ENSMUST00000169092.1
 Erlin1
ER lipid raft associated 1
chr13_-_52981027 1.291 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr13_-_29984219 1.156 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr17_-_27133902 0.993 ENSMUST00000119227.1
ENSMUST00000025045.8
 Uqcc2

ubiquinol-cytochrome c reductase complex assembly factor 2

chr17_-_27133620 0.966 ENSMUST00000118613.1
 Uqcc2
ubiquinol-cytochrome c reductase complex assembly factor 2
chr15_+_44787746 0.841 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr1_+_74771886 0.825 ENSMUST00000006716.6
 Wnt6
wingless-related MMTV integration site 6
chr14_-_68124836 0.810 ENSMUST00000111089.1
ENSMUST00000022638.5
 Nefm

neurofilament, medium polypeptide

chr11_-_120348513 0.729 ENSMUST00000071555.6
 Actg1
actin, gamma, cytoplasmic 1
chr11_-_89302545 0.721 ENSMUST00000061728.3
 Nog
noggin
chr11_+_121259983 0.703 ENSMUST00000106113.1
 Foxk2
forkhead box K2
chr15_-_44788016 0.699 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr8_-_106893581 0.696 ENSMUST00000176437.1
ENSMUST00000177068.1
ENSMUST00000169312.1
ENSMUST00000176515.1
 Chtf8



CTF8, chromosome transmission fidelity factor 8



chr6_-_125165707 0.684 ENSMUST00000118875.1
 Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr11_-_120348475 0.683 ENSMUST00000062147.7
ENSMUST00000128055.1
 Actg1

actin, gamma, cytoplasmic 1

chrX_-_93832106 0.680 ENSMUST00000045748.6
 Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chr8_-_106893515 0.677 ENSMUST00000176090.1
 Chtf8
CTF8, chromosome transmission fidelity factor 8
chr6_-_72958465 0.663 ENSMUST00000114050.1
 Tmsb10
thymosin, beta 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.3 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.2 2.0 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 2.0 GO:0045214 sarcomere organization(GO:0045214)
0.2 1.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.3 1.7 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0 1.7 GO:0071229 cellular response to acid chemical(GO:0071229)
0.2 1.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 1.5 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.2 1.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.3 1.2 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.2 1.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.3 1.0 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 1.0 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.3 0.8 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.3 0.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.2 0.7 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0 0.7 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.7 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.7 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.2 0.6 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.2 GO:0043034 costamere(GO:0043034)
0.1 1.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.5 GO:0043196 varicosity(GO:0043196)
0.2 1.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 1.2 GO:0097452 GAIT complex(GO:0097452)
0.1 0.8 GO:0005883 neurofilament(GO:0005883)
0.1 0.8 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 0.7 GO:0097433 dense body(GO:0097433)
0.1 0.7 GO:1904115 axon cytoplasm(GO:1904115)
0.2 0.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 0.5 GO:0034455 t-UTP complex(GO:0034455)
0.0 0.5 GO:0046930 pore complex(GO:0046930)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.4 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0015485 cholesterol binding(GO:0015485)
0.0 2.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 1.8 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 1.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 1.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 1.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4 1.2 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.0 1.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.2 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.3 1.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.8 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.7 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.7 GO:0019955 cytokine binding(GO:0019955)
0.2 0.6 GO:0030292 hyalurononglucosaminidase activity(GO:0004415) protein tyrosine kinase inhibitor activity(GO:0030292)
0.2 0.6 GO:0031893 vasopressin receptor binding(GO:0031893)