Motif ID: Rela_Rel_Nfkb1

Z-value: 0.929

Transcription factors associated with Rela_Rel_Nfkb1:

Gene SymbolEntrez IDGene Name
Nfkb1 ENSMUSG00000028163.11 Nfkb1
Rel ENSMUSG00000020275.8 Rel
Rela ENSMUSG00000024927.7 Rela

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Relamm10_v2_chr19_+_5637475_5637486-0.391.6e-01Click!
Nfkb1mm10_v2_chr3_-_135691512_1356915640.391.7e-01Click!


Activity profile for motif Rela_Rel_Nfkb1.

activity profile for motif Rela_Rel_Nfkb1


Sorted Z-values histogram for motif Rela_Rel_Nfkb1

Sorted Z-values for motif Rela_Rel_Nfkb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rela_Rel_Nfkb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_81333129 1.868 ENSMUST00000085238.6
ENSMUST00000182208.1
 Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr14_-_30607808 1.650 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chr4_+_42240639 1.307 ENSMUST00000117202.2
 Gm10600
predicted gene 10600
chr1_+_171250416 1.130 ENSMUST00000111315.1
ENSMUST00000006570.5
 Adamts4

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4

chr1_+_64532790 1.122 ENSMUST00000049932.5
ENSMUST00000087366.4
ENSMUST00000171164.1
 Creb1


cAMP responsive element binding protein 1


chr17_-_83631892 1.119 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr4_+_42091207 1.106 ENSMUST00000178882.1
 Gm3893
predicted gene 3893
chr16_-_55838827 0.903 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
 Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr3_-_126998408 0.878 ENSMUST00000182764.1
ENSMUST00000044443.8
 Ank2

ankyrin 2, brain

chr12_+_111166485 0.823 ENSMUST00000139162.1
 Traf3
TNF receptor-associated factor 3
chr6_+_42286709 0.785 ENSMUST00000163936.1
 Clcn1
chloride channel 1
chr14_-_30626196 0.769 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr4_-_82505749 0.720 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr10_+_13966268 0.693 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr4_+_100776664 0.692 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr9_+_64811313 0.664 ENSMUST00000038890.5
 Dennd4a
DENN/MADD domain containing 4A
chr11_-_109298066 0.652 ENSMUST00000106706.1
 Rgs9
regulator of G-protein signaling 9
chr1_+_185454803 0.651 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr10_-_95415283 0.636 ENSMUST00000119917.1
 Socs2
suppressor of cytokine signaling 2
chr12_+_52699297 0.629 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.4 GO:0006680 glucosylceramide catabolic process(GO:0006680) negative regulation of filopodium assembly(GO:0051490)
0.6 1.9 GO:1990034 calcium ion export from cell(GO:1990034)
0.2 1.5 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 1.2 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.4 1.1 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.2 1.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 1.1 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 0.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 0.9 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.1 0.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.9 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.8 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 0.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.7 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.1 0.7 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 0.6 GO:0061144 alveolar secondary septum development(GO:0061144)
0.2 0.6 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 2.0 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.5 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.3 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.2 GO:0031430 M band(GO:0031430)
0.0 1.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.0 GO:0001917 photoreceptor inner segment(GO:0001917)
0.2 0.9 GO:0031523 Myb complex(GO:0031523)
0.0 0.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.8 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.7 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.7 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.6 GO:0042581 specific granule(GO:0042581)
0.0 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.6 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.6 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.4 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.2 1.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 1.5 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 1.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 1.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.0 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.2 0.9 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.8 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.7 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 0.6 GO:0043495 protein anchor(GO:0043495)
0.1 0.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)