Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 4.642

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:

Gene SymbolEntrez IDGene Name
Irf1 ENSMUSG00000018899.10 Irf1
Irf2 ENSMUSG00000031627.7 Irf2
Irf7 ENSMUSG00000025498.8 Irf7
Irf8 ENSMUSG00000041515.3 Irf8
Irf9 ENSMUSG00000002325.8 Irf9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770458_537705090.631.6e-02Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.516.0e-02Click!
Irf2mm10_v2_chr8_+_46739745_467397910.303.0e-01Click!
Irf7mm10_v2_chr7_-_141266415_1412664810.273.5e-01Click!
Irf9mm10_v2_chr14_+_55604550_55604579-0.146.3e-01Click!


Activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7.

activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7


Sorted Z-values histogram for motif Irf2_Irf1_Irf8_Irf9_Irf7

Sorted Z-values for motif Irf2_Irf1_Irf8_Irf9_Irf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 40.299 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3027439 37.896 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3023547 35.398 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr2_-_98667264 35.115 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3000922 33.264 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3017408 32.919 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3034599 31.808 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3015654 31.594 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3037111 30.179 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3004457 29.769 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr14_-_19418930 28.866 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3036877 27.928 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3005125 25.590 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3025417 25.380 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3018753 22.881 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_+_98662227 16.680 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr11_+_70459940 10.766 ENSMUST00000147289.1
ENSMUST00000126105.1
 Zmynd15

zinc finger, MYND-type containing 15

chr16_+_23609895 9.182 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr4_-_40239779 9.158 ENSMUST00000037907.6
 Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_+_122147680 8.670 ENSMUST00000102476.4
 B2m
beta-2 microglobulin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 235 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 14.8 GO:1900122 positive regulation of receptor binding(GO:1900122)
3.7 14.6 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
3.5 14.2 GO:0009597 detection of virus(GO:0009597)
0.7 12.6 GO:0042832 defense response to protozoan(GO:0042832)
3.8 11.4 GO:2000562 negative regulation of interferon-gamma secretion(GO:1902714) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.7 10.8 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1 10.8 GO:0007286 spermatid development(GO:0007286)
0.4 10.6 GO:0035456 response to interferon-beta(GO:0035456)
3.4 10.3 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.3 9.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
3.1 9.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
1.0 7.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.5 7.5 GO:0010447 response to acidic pH(GO:0010447)
0.1 7.3 GO:0016052 carbohydrate catabolic process(GO:0016052)
0.1 6.0 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.2 5.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 5.0 GO:0071346 cellular response to interferon-gamma(GO:0071346)
1.6 4.7 GO:1902915 negative regulation of protein import into nucleus, translocation(GO:0033159) protein poly-ADP-ribosylation(GO:0070212) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.3 4.6 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 4.5 GO:0006914 autophagy(GO:0006914)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 253.2 GO:0005575 cellular_component(GO:0005575)
1.6 20.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 14.2 GO:0032587 ruffle membrane(GO:0032587)
1.0 11.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 9.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 8.5 GO:0009986 cell surface(GO:0009986)
0.0 8.4 GO:0005770 late endosome(GO:0005770)
0.0 7.5 GO:0009897 external side of plasma membrane(GO:0009897)
2.5 7.4 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.1 6.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.9 GO:0005604 basement membrane(GO:0005604)
1.2 5.0 GO:1990111 spermatoproteasome complex(GO:1990111)
1.1 4.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 4.3 GO:0036126 sperm flagellum(GO:0036126)
0.0 4.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 3.2 GO:0005614 interstitial matrix(GO:0005614)
0.4 3.1 GO:0033269 internode region of axon(GO:0033269)
0.0 3.0 GO:0031519 PcG protein complex(GO:0031519)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 22.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 19.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 17.0 GO:0005525 GTP binding(GO:0005525)
1.9 11.4 GO:0016936 galactoside binding(GO:0016936)
0.8 10.8 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.8 10.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
2.9 8.7 GO:0004556 alpha-amylase activity(GO:0004556)
0.6 8.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 8.1 GO:0042826 histone deacetylase binding(GO:0042826)
1.5 7.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 5.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.2 5.6 GO:0001968 fibronectin binding(GO:0001968)
1.8 5.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 4.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
1.1 4.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 4.4 GO:0001948 glycoprotein binding(GO:0001948)
0.1 4.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 3.7 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 3.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.3 3.3 GO:0031386 protein tag(GO:0031386)