Motif ID: Gli3_Zic1

Z-value: 1.320

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic1mm10_v2_chr9_-_91365756_913657740.851.2e-04Click!
Gli3mm10_v2_chr13_+_15463837_154639800.224.5e-01Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 7.068 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr6_+_17463749 4.308 ENSMUST00000115443.1
 Met
met proto-oncogene
chr14_-_55560340 3.982 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr1_+_195017399 3.916 ENSMUST00000181273.1
 A330023F24Rik
RIKEN cDNA A330023F24 gene
chr9_-_54661870 3.828 ENSMUST00000034822.5
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr8_+_70501116 3.009 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr8_+_76902277 2.997 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr6_+_17463826 2.648 ENSMUST00000140070.1
 Met
met proto-oncogene
chr6_+_110645572 2.620 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr11_-_42182163 2.421 ENSMUST00000153147.1
 Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr10_-_127341583 2.340 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr8_-_105966038 2.339 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4

chr11_+_93098404 2.330 ENSMUST00000107859.1
ENSMUST00000042943.6
ENSMUST00000107861.1
ENSMUST00000107858.2
 Car10



carbonic anhydrase 10



chr2_-_155945282 2.304 ENSMUST00000040162.2
 Gdf5
growth differentiation factor 5
chr16_+_43503607 2.283 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr8_-_105637403 2.194 ENSMUST00000182046.1
 Gm5914
predicted gene 5914
chr8_-_105637350 2.100 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr7_+_35119285 2.094 ENSMUST00000042985.9
 Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr1_+_129273344 2.094 ENSMUST00000073527.6
ENSMUST00000040311.7
 Thsd7b

thrombospondin, type I, domain containing 7B

chr4_+_124657646 2.046 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 9.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 7.5 GO:0048663 neuron fate commitment(GO:0048663)
0.5 4.9 GO:0071420 cellular response to histamine(GO:0071420)
0.8 4.7 GO:0003383 apical constriction(GO:0003383)
0.1 4.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.3 3.5 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.5 3.0 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 3.0 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 3.0 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
1.0 2.9 GO:1904685 positive regulation of metalloendopeptidase activity(GO:1904685)
0.5 2.6 GO:0001661 conditioned taste aversion(GO:0001661)
0.4 2.6 GO:0036233 glycine import(GO:0036233)
0.6 2.3 GO:0060032 notochord regression(GO:0060032)
0.1 2.3 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 2.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 2.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 2.1 GO:0060591 chondroblast differentiation(GO:0060591)
0.3 2.1 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.7 2.0 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.5 2.0 GO:1904425 negative regulation of GTP binding(GO:1904425)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 8.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 6.5 GO:0043235 receptor complex(GO:0043235)
0.3 4.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.6 4.7 GO:0033269 internode region of axon(GO:0033269)
0.0 3.9 GO:0005925 focal adhesion(GO:0005925)
0.0 3.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.0 3.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 2.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 2.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 2.3 GO:0097542 ciliary tip(GO:0097542)
0.0 2.3 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.7 2.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.7 2.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.3 1.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 1.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 1.2 GO:0032420 stereocilium(GO:0032420)
0.0 1.2 GO:0005801 cis-Golgi network(GO:0005801)
0.1 1.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 1.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 10.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 4.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 4.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 4.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 3.6 GO:0005096 GTPase activator activity(GO:0005096)
0.5 3.2 GO:0036122 BMP binding(GO:0036122)
0.1 3.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 3.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.4 3.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.3 2.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 2.7 GO:0042562 hormone binding(GO:0042562)
0.9 2.6 GO:0070905 serine binding(GO:0070905)
0.4 2.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 2.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.4 2.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 2.3 GO:0048038 quinone binding(GO:0048038)
0.0 2.3 GO:0005125 cytokine activity(GO:0005125)
0.7 2.0 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.3 2.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)