Motif ID: Nkx6-1_Evx1_Hesx1

Z-value: 0.842

Transcription factors associated with Nkx6-1_Evx1_Hesx1:

Gene SymbolEntrez IDGene Name
Evx1 ENSMUSG00000005503.8 Evx1
Hesx1 ENSMUSG00000040726.8 Hesx1
Nkx6-1 ENSMUSG00000035187.8 Nkx6-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-1mm10_v2_chr5_-_101665195_101665226-0.156.0e-01Click!


Activity profile for motif Nkx6-1_Evx1_Hesx1.

activity profile for motif Nkx6-1_Evx1_Hesx1


Sorted Z-values histogram for motif Nkx6-1_Evx1_Hesx1

Sorted Z-values for motif Nkx6-1_Evx1_Hesx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-1_Evx1_Hesx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_93519499 3.676 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr17_+_17402672 3.643 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr1_-_155417394 2.982 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr14_-_12345847 2.582 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr5_-_84417359 2.366 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr8_-_109251698 2.277 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr5_+_139543889 2.256 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr1_+_72284367 2.061 ENSMUST00000027380.5
ENSMUST00000141783.1
 Tmem169

transmembrane protein 169

chr1_-_172027251 1.934 ENSMUST00000138714.1
 Vangl2
vang-like 2 (van gogh, Drosophila)
chr15_+_25773985 1.843 ENSMUST00000125667.1
 Myo10
myosin X
chr9_+_118478182 1.764 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr13_-_56252163 1.763 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr9_+_118478344 1.745 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr1_-_172027269 1.722 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr2_+_20737306 1.710 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr2_-_72986716 1.646 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chrX_-_143933089 1.560 ENSMUST00000087313.3
 Dcx
doublecortin
chr15_-_93595877 1.490 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr1_-_155417283 1.465 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr15_-_67113909 1.413 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 5.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.7 4.4 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
1.2 3.7 GO:0060489 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 3.6 GO:0097352 autophagosome maturation(GO:0097352)
1.2 3.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.3 2.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 2.7 GO:0021860 pyramidal neuron development(GO:0021860)
0.4 2.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.8 2.4 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.3 2.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 1.8 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.4 1.7 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 1.6 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.3 1.5 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.0 1.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.5 GO:0048706 embryonic skeletal system development(GO:0048706)
0.3 1.4 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 1.4 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 1.4 GO:0008347 glial cell migration(GO:0008347)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0031965 nuclear membrane(GO:0031965)
0.9 3.7 GO:0060187 cell pole(GO:0060187)
0.1 2.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.0 GO:0016459 myosin complex(GO:0016459)
0.1 1.9 GO:0033270 paranode region of axon(GO:0033270)
0.3 1.5 GO:0070826 paraferritin complex(GO:0070826)
0.0 1.3 GO:0097440 apical dendrite(GO:0097440)
0.2 1.2 GO:0008623 CHRAC(GO:0008623)
0.0 1.1 GO:0031672 A band(GO:0031672)
0.3 1.0 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 1.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.0 GO:0043204 perikaryon(GO:0043204)
0.2 0.9 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.9 GO:0043196 varicosity(GO:0043196)
0.1 0.9 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.9 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 0.8 GO:1990075 stereocilia ankle link complex(GO:0002142) periciliary membrane compartment(GO:1990075)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.4 GO:0001618 virus receptor activity(GO:0001618)
0.4 2.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 2.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 2.5 GO:0030507 spectrin binding(GO:0030507)
0.1 2.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 1.5 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 1.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 1.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 1.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.2 GO:0070888 E-box binding(GO:0070888)
0.1 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.1 GO:0019208 phosphatase regulator activity(GO:0019208)
0.2 1.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.0 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)