Motif ID: Tfdp1_Wt1_Egr2

Z-value: 2.609

Transcription factors associated with Tfdp1_Wt1_Egr2:

Gene SymbolEntrez IDGene Name
Egr2 ENSMUSG00000037868.9 Egr2
Tfdp1 ENSMUSG00000038482.10 Tfdp1
Wt1 ENSMUSG00000016458.7 Wt1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr2mm10_v2_chr10_+_67537861_67537930-0.303.1e-01Click!
Tfdp1mm10_v2_chr8_+_13339656_133396740.253.9e-01Click!


Activity profile for motif Tfdp1_Wt1_Egr2.

activity profile for motif Tfdp1_Wt1_Egr2


Sorted Z-values histogram for motif Tfdp1_Wt1_Egr2

Sorted Z-values for motif Tfdp1_Wt1_Egr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfdp1_Wt1_Egr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_125490688 19.395 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr7_+_123982799 9.825 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr11_+_7063423 9.575 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr11_+_119942763 9.409 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
 Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr16_-_22163299 8.533 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr12_+_112146187 8.506 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr18_-_13972617 8.467 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr11_-_95514570 8.354 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr11_-_95587691 7.682 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr11_+_77930800 7.045 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6

chr13_-_56252163 6.961 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr14_-_39472825 6.954 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr2_-_118703963 6.758 ENSMUST00000104937.1
 Ankrd63
ankyrin repeat domain 63
chr5_+_141241490 6.562 ENSMUST00000085774.4
 Sdk1
sidekick homolog 1 (chicken)
chr10_-_127534540 6.471 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr4_+_47353283 6.337 ENSMUST00000044234.7
 Tgfbr1
transforming growth factor, beta receptor I
chr11_-_33147400 6.317 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr1_-_52500679 6.307 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr2_-_162661075 6.301 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr7_-_34812677 6.266 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,008 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.8 19.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
1.3 18.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.8 16.1 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
1.9 13.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.9 13.0 GO:0051764 actin crosslink formation(GO:0051764)
0.4 11.6 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
1.8 10.9 GO:0060017 parathyroid gland development(GO:0060017)
0.7 10.8 GO:0007252 I-kappaB phosphorylation(GO:0007252)
1.3 10.6 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.8 10.6 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.9 10.1 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
3.2 9.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.4 9.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
2.9 8.7 GO:0050975 sensory perception of touch(GO:0050975)
0.9 8.7 GO:0008063 Toll signaling pathway(GO:0008063)
0.4 8.7 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.9 8.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 8.2 GO:0048148 behavioral response to cocaine(GO:0048148)
1.2 8.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 359 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 39.3 GO:0060076 excitatory synapse(GO:0060076)
0.3 39.1 GO:0043197 dendritic spine(GO:0043197)
0.4 27.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.7 23.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.4 22.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 17.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.4 16.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.0 15.2 GO:0043196 varicosity(GO:0043196)
0.2 14.6 GO:0016605 PML body(GO:0016605)
0.8 13.4 GO:0097470 ribbon synapse(GO:0097470)
0.2 12.9 GO:0005871 kinesin complex(GO:0005871)
0.4 11.1 GO:0071565 nBAF complex(GO:0071565)
0.1 10.2 GO:0031965 nuclear membrane(GO:0031965)
0.5 9.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 9.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.5 9.6 GO:0032279 asymmetric synapse(GO:0032279)
0.8 8.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.7 8.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.2 8.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.4 8.2 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 553 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 27.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 26.2 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.9 24.6 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.1 24.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
3.8 18.8 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.8 18.3 GO:0070064 proline-rich region binding(GO:0070064)
0.2 16.0 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 14.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 13.6 GO:0005096 GTPase activator activity(GO:0005096)
1.6 13.2 GO:0046790 virion binding(GO:0046790)
0.5 13.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 13.1 GO:0019905 syntaxin binding(GO:0019905)
2.2 13.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.8 12.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
1.0 12.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.0 11.4 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.2 11.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 11.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.5 11.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
1.5 10.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)