Motif ID: Mef2c

Z-value: 0.950


Transcription factors associated with Mef2c:

Gene SymbolEntrez IDGene Name
Mef2c ENSMUSG00000005583.10 Mef2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83504032_835040500.312.8e-01Click!


Activity profile for motif Mef2c.

activity profile for motif Mef2c


Sorted Z-values histogram for motif Mef2c

Sorted Z-values for motif Mef2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 197 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_69785507 2.730 ENSMUST00000182993.1
 Ank3
ankyrin 3, epithelial
chr13_+_16011851 1.549 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr19_-_5802640 1.298 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr2_-_57124003 1.282 ENSMUST00000112629.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr1_-_64122256 1.184 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr8_+_45658273 1.146 ENSMUST00000153798.1
 Sorbs2
sorbin and SH3 domain containing 2
chr4_+_82065924 1.111 ENSMUST00000161588.1
 Gm5860
predicted gene 5860
chr5_-_128953303 1.021 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr8_+_45658666 1.016 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr4_+_46039202 0.924 ENSMUST00000156200.1
 Tmod1
tropomodulin 1
chr18_-_47368830 0.911 ENSMUST00000019791.7
ENSMUST00000115449.2
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr1_-_12991109 0.901 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr8_+_45658731 0.901 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr3_-_56183678 0.899 ENSMUST00000029374.6
 Nbea
neurobeachin
chr11_+_77801325 0.896 ENSMUST00000151373.2
ENSMUST00000172303.2
ENSMUST00000130305.2
ENSMUST00000164334.1
ENSMUST00000092884.4
 Myo18a




myosin XVIIIA




chr3_+_103279293 0.893 ENSMUST00000029444.6
ENSMUST00000106860.1
 Trim33

tripartite motif-containing 33

chr2_+_48949495 0.879 ENSMUST00000112745.1
 Mbd5
methyl-CpG binding domain protein 5
chr6_+_42286709 0.855 ENSMUST00000163936.1
 Clcn1
chloride channel 1
chr11_+_20647149 0.823 ENSMUST00000109585.1
 Sertad2
SERTA domain containing 2
chr7_+_112742025 0.791 ENSMUST00000164363.1
 Tead1
TEA domain family member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 2.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 2.2 GO:0048813 dendrite morphogenesis(GO:0048813)
0.3 1.6 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.3 1.5 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.2 1.4 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.3 1.3 GO:0035063 nuclear speck organization(GO:0035063)
0.3 1.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 1.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 1.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 1.0 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 1.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 0.9 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 0.9 GO:0031033 myosin filament organization(GO:0031033)
0.1 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.9 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.9 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 0.8 GO:0080009 mRNA methylation(GO:0080009)
0.1 0.8 GO:0014883 transition between fast and slow fiber(GO:0014883) positive regulation of stem cell population maintenance(GO:1902459)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.6 GO:0016607 nuclear speck(GO:0016607)
0.5 1.5 GO:0043512 inhibin A complex(GO:0043512)
0.2 1.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 0.9 GO:0010369 chromocenter(GO:0010369)
0.0 0.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.8 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.4 GO:0090537 CERF complex(GO:0090537)
0.1 0.4 GO:0044316 cone cell pedicle(GO:0044316)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.6 GO:0043531 ADP binding(GO:0043531)
0.3 1.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 1.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.1 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.1 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 0.9 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.9 GO:0051018 protein kinase A binding(GO:0051018)
0.2 0.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.6 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)