Motif ID: Mef2c
Z-value: 0.950
Transcription factors associated with Mef2c:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Mef2c | ENSMUSG00000005583.10 | Mef2c |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mef2c | mm10_v2_chr13_+_83504032_83504050 | 0.31 | 2.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.5 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.3 | 1.3 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.3 | 1.3 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.3 | 1.0 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
| 0.3 | 1.6 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
| 0.3 | 1.5 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.3 | 0.9 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.2 | 1.4 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.2 | 0.7 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.2 | 0.6 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.2 | 0.9 | GO:0031033 | myosin filament organization(GO:0031033) |
| 0.2 | 1.1 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.2 | 0.5 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 0.2 | 0.5 | GO:0032512 | regulation of protein phosphatase type 2B activity(GO:0032512) |
| 0.1 | 0.7 | GO:0031133 | regulation of axon diameter(GO:0031133) |
| 0.1 | 0.4 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.1 | 0.4 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.1 | 0.7 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 0.1 | 1.3 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 0.5 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 0.1 | 0.3 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.1 | 0.3 | GO:0070375 | ERK5 cascade(GO:0070375) |
| 0.1 | 0.3 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.1 | 0.4 | GO:1900127 | positive regulation of hyaluronan biosynthetic process(GO:1900127) |
| 0.1 | 2.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.8 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.1 | 0.8 | GO:0014883 | transition between fast and slow fiber(GO:0014883) positive regulation of stem cell population maintenance(GO:1902459) |
| 0.1 | 0.1 | GO:1901420 | negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) negative regulation of response to alcohol(GO:1901420) |
| 0.1 | 0.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 0.6 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.1 | 0.4 | GO:0021780 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.1 | 0.5 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.1 | 0.2 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.1 | 0.5 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.4 | GO:0036506 | maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.0 | 0.9 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.0 | 0.1 | GO:1901509 | regulation of endothelial tube morphogenesis(GO:1901509) |
| 0.0 | 0.5 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.3 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.0 | 0.7 | GO:0008209 | androgen metabolic process(GO:0008209) |
| 0.0 | 0.2 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
| 0.0 | 0.4 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.8 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.2 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.0 | 0.5 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.6 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 0.3 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
| 0.0 | 0.1 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.0 | 0.3 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.0 | 0.2 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.0 | 0.4 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.0 | 0.1 | GO:0015840 | urea transport(GO:0015840) urea transmembrane transport(GO:0071918) |
| 0.0 | 0.3 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.9 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 0.3 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.1 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.0 | 1.0 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.5 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 0.7 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
| 0.0 | 0.2 | GO:0030813 | positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) |
| 0.0 | 0.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.1 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.0 | 0.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.0 | GO:0002024 | diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845) |
| 0.0 | 0.1 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
| 0.0 | 0.2 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 2.2 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.3 | 5.5 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.2 | 1.0 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 0.8 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.1 | 0.4 | GO:0090537 | CERF complex(GO:0090537) |
| 0.1 | 0.4 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.1 | 0.2 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.1 | 0.3 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.9 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.9 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 0.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.1 | GO:0031088 | platelet dense granule membrane(GO:0031088) platelet dense tubular network(GO:0031094) |
| 0.0 | 0.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.2 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 0.5 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.3 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 0.2 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.7 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 0.7 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 1.0 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.1 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.7 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.3 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.1 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.5 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.4 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 1.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.5 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.2 | 5.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.2 | 0.7 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.1 | 0.4 | GO:0070615 | nucleosome-dependent ATPase activity(GO:0070615) |
| 0.1 | 0.6 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.1 | 0.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 0.9 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.1 | 1.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.2 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 0.1 | 1.4 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 0.4 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.1 | 0.5 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 0.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 0.6 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.2 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 0.0 | 0.7 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.4 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 0.1 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.0 | 0.2 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.0 | 1.1 | GO:0034930 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131) |
| 0.0 | 1.6 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 0.3 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.2 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.0 | 1.4 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.7 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.2 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 0.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 0.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.4 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.0 | 0.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.4 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.1 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.0 | 0.1 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.0 | 0.5 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.0 | 0.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.9 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.1 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.0 | 0.5 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 0.1 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.0 | 1.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.3 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.2 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.5 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 0.4 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.1 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 0.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
