Motif ID: Pknox2_Pknox1

Z-value: 0.656

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox1mm10_v2_chr17_+_31564749_31564854-0.563.7e-02Click!
Pknox2mm10_v2_chr9_-_37147257_371473230.391.7e-01Click!


Activity profile for motif Pknox2_Pknox1.

activity profile for motif Pknox2_Pknox1


Sorted Z-values histogram for motif Pknox2_Pknox1

Sorted Z-values for motif Pknox2_Pknox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 102 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_113758638 2.916 ENSMUST00000099575.3
 Grem1
gremlin 1
chr9_+_113930934 1.266 ENSMUST00000084885.5
ENSMUST00000009885.7
 Ubp1

upstream binding protein 1

chr9_+_68653761 1.118 ENSMUST00000034766.7
 Rora
RAR-related orphan receptor alpha
chrX_-_109013389 1.020 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chr2_+_105682463 0.991 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr5_+_150673739 0.977 ENSMUST00000016569.4
ENSMUST00000038900.8
 Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr15_+_32920723 0.926 ENSMUST00000022871.5
 Sdc2
syndecan 2
chr2_-_116065047 0.922 ENSMUST00000028639.6
ENSMUST00000102538.4
 Meis2

Meis homeobox 2

chr11_+_23256001 0.872 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
 Xpo1



exportin 1, CRM1 homolog (yeast)



chr7_-_131410495 0.840 ENSMUST00000121033.1
ENSMUST00000046306.8
 Ikzf5

IKAROS family zinc finger 5

chr2_-_34913976 0.836 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr5_-_134747241 0.791 ENSMUST00000015138.9
 Eln
elastin
chr18_+_56432116 0.725 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr13_-_58274121 0.712 ENSMUST00000091579.4
 Gkap1
G kinase anchoring protein 1
chr8_-_115707778 0.710 ENSMUST00000109104.1
 Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr2_-_31142002 0.674 ENSMUST00000113560.1
ENSMUST00000113564.2
ENSMUST00000113562.2
 Fnbp1


formin binding protein 1


chr18_+_49832622 0.645 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr8_+_56294552 0.632 ENSMUST00000034026.8
 Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr7_+_112225856 0.609 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr17_-_48432723 0.575 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 2.9 GO:1901228 regulation of osteoclast proliferation(GO:0090289) negative regulation of bone mineralization involved in bone maturation(GO:1900158) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.2 1.1 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.2 1.0 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.0 1.0 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 1.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.8 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 0.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.7 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.7 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.2 0.6 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.6 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.1 0.6 GO:2000252 negative regulation of feeding behavior(GO:2000252)
0.1 0.6 GO:0097070 ductus arteriosus closure(GO:0097070)
0.0 0.6 GO:0080111 DNA demethylation(GO:0080111)
0.2 0.5 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.5 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.4 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0005642 annulate lamellae(GO:0005642)
0.3 0.8 GO:0071953 elastic fiber(GO:0071953)
0.0 0.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.4 GO:0031415 NatA complex(GO:0031415)
0.0 0.3 GO:0098536 deuterosome(GO:0098536)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.2 GO:0000801 central element(GO:0000801)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.0 GO:1990037 Lewy body core(GO:1990037)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.9 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.3 1.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.0 GO:0020037 heme binding(GO:0020037)
0.0 0.9 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.8 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.7 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.2 0.7 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.2 0.6 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 0.6 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.0 0.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 0.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.5 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)