Motif ID: Egr3

Z-value: 1.301


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_700774450.224.6e-01Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_144209558 7.918 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr12_-_67221221 4.957 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr17_-_87282793 3.804 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr6_-_49214954 3.729 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr17_-_87282771 3.595 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr7_-_119184374 3.028 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr10_+_69534208 2.969 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
 Ank3





ankyrin 3, epithelial





chr17_-_83631892 2.635 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr10_+_69533803 2.231 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
 Ank3


ankyrin 3, epithelial


chr10_+_69534039 2.162 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr3_-_127162328 2.084 ENSMUST00000182994.1
 Ank2
ankyrin 2, brain
chrX_+_143664365 1.931 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
 Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr17_+_87282880 1.902 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr7_+_48959089 1.748 ENSMUST00000183659.1
 Nav2
neuron navigator 2
chr10_+_40883819 1.719 ENSMUST00000105509.1
 Wasf1
WAS protein family, member 1
chr4_+_123183722 1.684 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr1_-_156939387 1.639 ENSMUST00000171292.1
 Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr4_+_123183456 1.599 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr1_+_36068371 1.571 ENSMUST00000088174.3
 Hs6st1
heparan sulfate 6-O-sulfotransferase 1
chr5_+_77265454 1.551 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.0 7.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 3.8 GO:0051028 mRNA transport(GO:0051028)
0.1 3.2 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.3 3.0 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 3.0 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 2.6 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.2 2.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.7 2.0 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.7 2.0 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 1.9 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.4 1.7 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.4 1.6 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.3 1.6 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.3 1.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 1.4 GO:0070166 enamel mineralization(GO:0070166)
0.0 1.2 GO:0006379 mRNA cleavage(GO:0006379)
0.2 1.1 GO:0046684 response to pyrethroid(GO:0046684)
0.0 1.1 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 1.1 GO:0035640 exploration behavior(GO:0035640)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 7.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 5.8 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.0 GO:0031209 SCAR complex(GO:0031209)
0.0 2.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 2.1 GO:0031430 M band(GO:0031430)
0.3 2.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 1.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.8 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.2 0.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 6.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 4.2 GO:0008146 sulfotransferase activity(GO:0008146)
0.3 4.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 3.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 3.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 3.0 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 3.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 2.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 2.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 1.7 GO:0008201 heparin binding(GO:0008201)
0.1 1.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 1.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 1.1 GO:0031402 sodium ion binding(GO:0031402)
0.3 1.0 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 0.9 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 0.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.7 GO:0005522 profilin binding(GO:0005522)