Motif ID: Egr3

Z-value: 1.301


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_700774450.224.6e-01Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_144209558 7.918 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr12_-_67221221 4.957 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr17_-_87282793 3.804 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr6_-_49214954 3.729 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr17_-_87282771 3.595 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr7_-_119184374 3.028 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr10_+_69534208 2.969 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
 Ank3





ankyrin 3, epithelial





chr17_-_83631892 2.635 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr10_+_69533803 2.231 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
 Ank3


ankyrin 3, epithelial


chr10_+_69534039 2.162 ENSMUST00000182557.1
 Ank3
ankyrin 3, epithelial
chr3_-_127162328 2.084 ENSMUST00000182994.1
 Ank2
ankyrin 2, brain
chrX_+_143664365 1.931 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
 Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr17_+_87282880 1.902 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr7_+_48959089 1.748 ENSMUST00000183659.1
 Nav2
neuron navigator 2
chr10_+_40883819 1.719 ENSMUST00000105509.1
 Wasf1
WAS protein family, member 1
chr4_+_123183722 1.684 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr1_-_156939387 1.639 ENSMUST00000171292.1
 Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr4_+_123183456 1.599 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr1_+_36068371 1.571 ENSMUST00000088174.3
 Hs6st1
heparan sulfate 6-O-sulfotransferase 1
chr5_+_77265454 1.551 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chr12_-_51971289 1.532 ENSMUST00000040583.5
 Heatr5a
HEAT repeat containing 5A
chr11_-_109722214 1.429 ENSMUST00000020938.7
 Fam20a
family with sequence similarity 20, member A
chr11_+_71750680 1.406 ENSMUST00000021168.7
 Wscd1
WSC domain containing 1
chr1_-_157412576 1.349 ENSMUST00000078308.6
ENSMUST00000139470.1
 Rasal2

RAS protein activator like 2

chrX_+_143664290 1.317 ENSMUST00000112868.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr10_-_29144194 1.268 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr11_+_71750980 1.242 ENSMUST00000108511.1
 Wscd1
WSC domain containing 1
chr10_+_40883469 1.235 ENSMUST00000019975.7
 Wasf1
WAS protein family, member 1
chr2_+_104590453 1.166 ENSMUST00000028599.7
 Cstf3
cleavage stimulation factor, 3' pre-RNA, subunit 3
chr6_+_103510874 1.126 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr12_+_49382791 1.088 ENSMUST00000179669.1
 Foxg1
forkhead box G1
chr9_+_21616230 1.069 ENSMUST00000174008.1
 Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr11_-_23895208 1.057 ENSMUST00000102863.2
ENSMUST00000020513.3
 Papolg

poly(A) polymerase gamma

chr2_-_65529275 1.056 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chrX_-_48513518 1.029 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr9_+_21616166 0.972 ENSMUST00000034707.8
ENSMUST00000098948.3
 Smarca4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

chr13_-_41847626 0.943 ENSMUST00000121404.1
 Adtrp
androgen dependent TFPI regulating protein
chr7_+_100372224 0.924 ENSMUST00000051777.8
ENSMUST00000098259.4
 C2cd3

C2 calcium-dependent domain containing 3

chr8_+_79028317 0.906 ENSMUST00000087927.4
ENSMUST00000098614.2
 Zfp827

zinc finger protein 827

chr5_-_138279960 0.876 ENSMUST00000014089.7
ENSMUST00000161827.1
 Gpc2

glypican 2 (cerebroglycan)

chr10_-_40883073 0.875 ENSMUST00000044166.7
 Cdc40
cell division cycle 40
chr12_+_49383007 0.869 ENSMUST00000021333.3
 Foxg1
forkhead box G1
chr6_-_30896735 0.850 ENSMUST00000048774.6
ENSMUST00000166192.1
ENSMUST00000135230.1
 Copg2


coatomer protein complex, subunit gamma 2


chr2_+_32395896 0.797 ENSMUST00000028162.3
 Ptges2
prostaglandin E synthase 2
chr1_+_125676969 0.787 ENSMUST00000027581.6
 Gpr39
G protein-coupled receptor 39
chr4_-_129662442 0.746 ENSMUST00000003828.4
 Kpna6
karyopherin (importin) alpha 6
chr2_+_3114220 0.679 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr12_+_108635743 0.650 ENSMUST00000172409.1
 Evl
Ena-vasodilator stimulated phosphoprotein
chr16_+_94370786 0.649 ENSMUST00000147046.1
ENSMUST00000149885.1
ENSMUST00000127667.1
ENSMUST00000119131.1
ENSMUST00000145883.1
 Ttc3




tetratricopeptide repeat domain 3




chr4_-_41695935 0.640 ENSMUST00000145379.1
 Cntfr
ciliary neurotrophic factor receptor
chr19_-_38224096 0.604 ENSMUST00000067167.5
 Fra10ac1
FRA10AC1 homolog (human)
chr7_-_144939823 0.603 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr10_+_69533761 0.594 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr11_-_33276334 0.537 ENSMUST00000183831.1
 Gm12117
predicted gene 12117
chr3_+_135438722 0.535 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr7_+_80860909 0.522 ENSMUST00000132163.1
ENSMUST00000147125.1
 Zscan2

zinc finger and SCAN domain containing 2

chr10_-_18023229 0.497 ENSMUST00000020002.7
 Abracl
ABRA C-terminal like
chr9_+_44499126 0.495 ENSMUST00000074989.5
 Bcl9l
B cell CLL/lymphoma 9-like
chr8_+_62951361 0.485 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr4_+_99955715 0.444 ENSMUST00000102783.4
 Pgm2
phosphoglucomutase 2
chrX_+_101274023 0.438 ENSMUST00000117706.1
 Med12
mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
chr9_-_55048544 0.437 ENSMUST00000034854.6
 Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
chr1_-_164307443 0.435 ENSMUST00000027866.4
ENSMUST00000120447.1
ENSMUST00000086032.3
 Blzf1


basic leucine zipper nuclear factor 1


chr9_-_58204310 0.431 ENSMUST00000114144.2
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr13_-_41847482 0.424 ENSMUST00000072012.3
 Adtrp
androgen dependent TFPI regulating protein
chr18_-_12305638 0.407 ENSMUST00000122408.1
ENSMUST00000118525.1
ENSMUST00000142066.1
 Ankrd29


ankyrin repeat domain 29


chr11_+_98937669 0.369 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr1_+_74506044 0.340 ENSMUST00000087215.5
 Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr9_-_66124872 0.332 ENSMUST00000034946.8
 Snx1
sorting nexin 1
chr7_-_141539784 0.328 ENSMUST00000118694.1
ENSMUST00000153191.1
ENSMUST00000166082.1
ENSMUST00000026586.6
 Chid1



chitinase domain containing 1



chr19_+_6975048 0.307 ENSMUST00000070850.6
 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr10_-_5922341 0.302 ENSMUST00000117676.1
ENSMUST00000019909.7
 Rgs17

regulator of G-protein signaling 17

chrX_+_101274198 0.284 ENSMUST00000117203.1
ENSMUST00000087948.4
ENSMUST00000087956.5
 Med12


mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)


chr11_-_98775333 0.284 ENSMUST00000064941.6
 Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr18_-_41951187 0.276 ENSMUST00000070949.4
 Prelid2
PRELI domain containing 2
chr7_-_100371889 0.248 ENSMUST00000032963.8
 Ppme1
protein phosphatase methylesterase 1
chr3_+_97901190 0.232 ENSMUST00000029476.2
ENSMUST00000122288.1
 Sec22b

SEC22 vesicle trafficking protein homolog B (S. cerevisiae)

chr7_+_144896523 0.229 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr19_+_16956110 0.199 ENSMUST00000087689.4
 Prune2
prune homolog 2 (Drosophila)
chr4_+_57637816 0.183 ENSMUST00000150412.1
 Gm20459
predicted gene 20459
chr2_+_121413775 0.175 ENSMUST00000028683.7
 Pdia3
protein disulfide isomerase associated 3
chr18_-_37935403 0.164 ENSMUST00000080033.6
ENSMUST00000115631.1
 Diap1

diaphanous homolog 1 (Drosophila)

chr10_+_29143996 0.135 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr6_-_83572429 0.131 ENSMUST00000068054.7
 Stambp
STAM binding protein
chr2_-_173119402 0.129 ENSMUST00000094287.3
ENSMUST00000179693.1
 Ctcfl

CCCTC-binding factor (zinc finger protein)-like

chr5_-_62765618 0.125 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_105452326 0.114 ENSMUST00000098761.3
 Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr6_+_113307160 0.104 ENSMUST00000113122.1
ENSMUST00000113119.1
ENSMUST00000113121.1
ENSMUST00000113117.1
 Brpf1



bromodomain and PHD finger containing, 1



chr4_-_129696579 0.102 ENSMUST00000137640.1
 Tmem39b
transmembrane protein 39b
chr4_+_40948401 0.102 ENSMUST00000030128.5
 Chmp5
charged multivesicular body protein 5
chr13_-_107022027 0.086 ENSMUST00000117539.1
ENSMUST00000122233.1
ENSMUST00000022204.9
ENSMUST00000159772.1
 Kif2a



kinesin family member 2A



chr2_+_75659253 0.076 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
 Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr9_+_106203108 0.063 ENSMUST00000024047.5
 Twf2
twinfilin, actin-binding protein, homolog 2 (Drosophila)
chr4_-_126968124 0.063 ENSMUST00000106108.2
 Zmym4
zinc finger, MYM-type 4
chr10_-_5922385 0.056 ENSMUST00000131996.1
ENSMUST00000064225.7
 Rgs17

regulator of G-protein signaling 17

chr7_+_4740137 0.041 ENSMUST00000130215.1
ENSMUST00000108582.3
 Suv420h2

suppressor of variegation 4-20 homolog 2 (Drosophila)

chr18_-_37935378 0.031 ENSMUST00000025337.7
 Diap1
diaphanous homolog 1 (Drosophila)
chr9_-_78481724 0.009 ENSMUST00000042235.8
 Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr18_-_37935429 0.003 ENSMUST00000115634.1
 Diap1
diaphanous homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.7 8.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.7 2.0 GO:0061626 pharyngeal arch artery morphogenesis(GO:0061626)
0.7 2.0 GO:0021852 pyramidal neuron migration(GO:0021852)
0.4 1.7 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.4 1.6 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.3 3.0 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.3 1.6 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.3 0.9 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.3 0.8 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.3 1.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 1.4 GO:0070166 enamel mineralization(GO:0070166)
0.2 2.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 0.9 GO:0061511 centriole elongation(GO:0061511)
0.2 1.1 GO:0046684 response to pyrethroid(GO:0046684)
0.2 0.6 GO:0003360 brainstem development(GO:0003360)
0.1 0.4 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.1 0.3 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.1 3.2 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 0.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.6 GO:0070141 response to UV-A(GO:0070141)
0.1 1.0 GO:1903624 regulation of apoptotic DNA fragmentation(GO:1902510) regulation of DNA catabolic process(GO:1903624)
0.1 0.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.7 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 0.7 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 0.2 GO:1903334 positive regulation of protein folding(GO:1903334)
0.1 0.2 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 3.0 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 0.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.9 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 1.2 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.8 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 1.1 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 3.8 GO:0051028 mRNA transport(GO:0051028)
0.0 0.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.1 GO:0035640 exploration behavior(GO:0035640)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 2.6 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 0.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 0.4 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:0032532 regulation of microvillus length(GO:0032532)
0.0 0.9 GO:0007224 smoothened signaling pathway(GO:0007224)
0.0 0.1 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 2.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 3.0 GO:0031209 SCAR complex(GO:0031209)
0.2 0.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 2.1 GO:0031430 M band(GO:0031430)
0.1 1.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.8 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 5.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 7.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 2.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 10.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 4.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 0.9 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.2 0.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 2.0 GO:0030957 Tat protein binding(GO:0030957)
0.2 3.0 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.2 1.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 1.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 3.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.3 GO:0004568 chitinase activity(GO:0004568)
0.1 0.6 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 2.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.3 GO:1990460 leptin receptor binding(GO:1990460)
0.1 4.2 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 1.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 3.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.2 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.1 1.1 GO:0031402 sodium ion binding(GO:0031402)
0.1 0.7 GO:0005522 profilin binding(GO:0005522)
0.0 3.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.4 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.7 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.1 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.7 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 0.2 GO:0051723 protein methylesterase activity(GO:0051723)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 6.0 GO:0046982 protein heterodimerization activity(GO:0046982)