Motif ID: Stat4_Stat3_Stat5b

Z-value: 0.867

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat3mm10_v2_chr11_-_100939540_1009395660.146.3e-01Click!
Stat4mm10_v2_chr1_+_52008210_520082540.107.4e-01Click!
Stat5bmm10_v2_chr11_-_100850724_100850763-0.078.2e-01Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 3.442 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr10_-_20312239 2.011 ENSMUST00000092680.2
 4933406P04Rik
RIKEN cDNA 4933406P04 gene
chr10_+_20312461 1.717 ENSMUST00000092678.3
ENSMUST00000043881.5
 Bclaf1

BCL2-associated transcription factor 1

chr13_-_67755132 1.472 ENSMUST00000091520.6
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr12_+_11265867 1.426 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6
chr3_-_80802789 1.407 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr13_-_67755192 1.356 ENSMUST00000144183.1
 Zfp85-rs1
zinc finger protein 85, related sequence 1
chr10_-_95416850 1.316 ENSMUST00000020215.9
 Socs2
suppressor of cytokine signaling 2
chr15_-_93519499 1.228 ENSMUST00000109255.2
 Prickle1
prickle homolog 1 (Drosophila)
chr5_+_14025305 1.151 ENSMUST00000073957.6
 Sema3e
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr3_+_69004711 1.120 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr1_+_34005872 0.914 ENSMUST00000182296.1
 Dst
dystonin
chr4_+_148602527 0.890 ENSMUST00000105701.2
ENSMUST00000052060.6
 Masp2

mannan-binding lectin serine peptidase 2

chr10_-_95417099 0.806 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr14_-_65833963 0.768 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr2_+_3424123 0.767 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
 Dclre1c



DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)



chr5_-_100500592 0.744 ENSMUST00000149714.1
ENSMUST00000046154.5
 Lin54

lin-54 homolog (C. elegans)

chr7_-_128461630 0.724 ENSMUST00000106226.2
 Tial1
Tia1 cytotoxic granule-associated RNA binding protein-like 1
chr12_-_45074112 0.724 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr7_-_128461168 0.720 ENSMUST00000106228.1
 Tial1
Tia1 cytotoxic granule-associated RNA binding protein-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0017145 stem cell division(GO:0017145)
0.1 2.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.2 1.7 GO:2001198 regulation of dendritic cell differentiation(GO:2001198)
0.1 1.6 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 1.6 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.4 1.5 GO:0071139 resolution of recombination intermediates(GO:0071139)
0.4 1.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.1 1.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 1.2 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.3 1.1 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) cytosol to ER transport(GO:0046967) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.2 1.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.3 1.0 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 1.0 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.9 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.8 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.7 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.6 GO:0016607 nuclear speck(GO:0016607)
0.5 1.4 GO:0035061 interchromatin granule(GO:0035061)
0.1 1.4 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.2 1.1 GO:0000796 condensin complex(GO:0000796)
0.2 1.1 GO:0042825 TAP complex(GO:0042825)
0.3 1.0 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 1.0 GO:0005827 polar microtubule(GO:0005827)
0.2 0.9 GO:0031673 H zone(GO:0031673)
0.2 0.8 GO:0090537 CERF complex(GO:0090537)
0.2 0.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.8 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 0.6 GO:0010369 chromocenter(GO:0010369)
0.0 0.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0017091 AU-rich element binding(GO:0017091)
0.5 2.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 1.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 1.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.2 GO:0038191 neuropilin binding(GO:0038191)
0.3 1.1 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.3 1.0 GO:0031208 POZ domain binding(GO:0031208)
0.3 1.0 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.2 0.9 GO:0016972 thiol oxidase activity(GO:0016972)
0.3 0.8 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.2 0.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.8 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.7 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.7 GO:0001846 opsonin binding(GO:0001846)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 0.5 GO:0048019 receptor antagonist activity(GO:0048019)
0.2 0.5 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)