Motif ID: Pbx1_Pbx3

Z-value: 0.734

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx1mm10_v2_chr1_-_168431502_168431513-0.841.6e-04Click!
Pbx3mm10_v2_chr2_-_34372004_343720440.723.8e-03Click!


Activity profile for motif Pbx1_Pbx3.

activity profile for motif Pbx1_Pbx3


Sorted Z-values histogram for motif Pbx1_Pbx3

Sorted Z-values for motif Pbx1_Pbx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 1.727 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr7_-_31054815 1.601 ENSMUST00000071697.4
ENSMUST00000108110.3
 Fxyd1

FXYD domain-containing ion transport regulator 1

chr18_-_84086379 1.359 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr4_+_3938904 1.200 ENSMUST00000120732.1
ENSMUST00000041122.4
ENSMUST00000121651.1
ENSMUST00000121210.1
ENSMUST00000119307.1
ENSMUST00000123769.1
 Chchd7





coiled-coil-helix-coiled-coil-helix domain containing 7





chr2_-_116065047 1.159 ENSMUST00000028639.6
ENSMUST00000102538.4
 Meis2

Meis homeobox 2

chr4_+_3938888 1.144 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr17_+_83215271 1.094 ENSMUST00000170794.1
 Pkdcc
protein kinase domain containing, cytoplasmic
chr19_+_55741810 1.085 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr3_-_87263518 0.959 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr8_-_115707778 0.937 ENSMUST00000109104.1
 Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr10_-_81600857 0.923 ENSMUST00000151858.1
ENSMUST00000142948.1
ENSMUST00000072020.2
 Tle6


transducin-like enhancer of split 6, homolog of Drosophila E(spl)


chr9_+_113930934 0.911 ENSMUST00000084885.5
ENSMUST00000009885.7
 Ubp1

upstream binding protein 1

chr4_-_43523746 0.900 ENSMUST00000150592.1
 Tpm2
tropomyosin 2, beta
chrX_-_109013389 0.855 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chr5_-_109558957 0.854 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr11_-_19018714 0.853 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chr7_+_141475459 0.823 ENSMUST00000138092.1
ENSMUST00000146305.1
 Tspan4

tetraspanin 4

chr4_-_43523595 0.814 ENSMUST00000107914.3
 Tpm2
tropomyosin 2, beta
chr9_-_116175318 0.806 ENSMUST00000061101.4
ENSMUST00000035014.6
 Tgfbr2

transforming growth factor, beta receptor II

chr4_-_43523388 0.799 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 1.7 GO:0042572 retinol metabolic process(GO:0042572)
0.5 1.6 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.1 1.6 GO:0035855 megakaryocyte development(GO:0035855)
0.5 1.4 GO:0060023 soft palate development(GO:0060023)
0.1 1.4 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 1.2 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.4 1.1 GO:0097402 neuroblast migration(GO:0097402)
0.2 1.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 1.1 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.1 1.0 GO:0043383 negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060)
0.2 0.9 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.9 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743) T-helper 2 cell cytokine production(GO:0035745)
0.2 0.8 GO:0003430 tolerance induction to self antigen(GO:0002513) growth plate cartilage chondrocyte growth(GO:0003430) lens fiber cell apoptotic process(GO:1990086)
0.1 0.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.8 GO:0060346 bone trabecula formation(GO:0060346)
0.2 0.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 0.7 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.3 0.6 GO:0061074 regulation of neural retina development(GO:0061074)
0.2 0.6 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 2.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.2 1.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 1.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 0.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.6 GO:0008091 spectrin(GO:0008091)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.1 0.5 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.5 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.4 GO:1990246 uniplex complex(GO:1990246)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.1 0.3 GO:0000801 central element(GO:0000801)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.3 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 1.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.7 GO:0003823 antigen binding(GO:0003823)
0.3 1.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.9 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.2 0.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 0.6 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 0.6 GO:0036004 GAF domain binding(GO:0036004)
0.1 0.6 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)