Motif ID: Onecut1_Cux2

Z-value: 2.035

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux2mm10_v2_chr5_-_122049822_122049882-0.724.0e-03Click!
Onecut1mm10_v2_chr9_+_74861888_74861921-0.165.9e-01Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Showing 1 to 20 of 86 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_64090241 25.122 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090265 22.599 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr14_+_68083853 8.663 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr19_-_57197435 8.603 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197377 8.573 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197496 8.367 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr1_-_158958367 7.310 ENSMUST00000159861.2
 Pappa2
pappalysin 2
chr19_-_57197556 6.647 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr9_-_50739365 6.463 ENSMUST00000117093.1
ENSMUST00000121634.1
 Dixdc1

DIX domain containing 1

chr7_+_75848338 6.341 ENSMUST00000092073.5
ENSMUST00000171155.2
 Klhl25

kelch-like 25

chrX_-_43274786 5.794 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr12_+_72441933 5.551 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr1_+_165302625 5.333 ENSMUST00000111450.1
 Gpr161
G protein-coupled receptor 161
chr7_+_35802593 5.150 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chrX_+_41401128 5.142 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr12_+_72441852 4.413 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr4_+_62965560 3.676 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr13_+_93304940 3.442 ENSMUST00000109497.1
ENSMUST00000109498.1
ENSMUST00000060490.4
ENSMUST00000109492.1
ENSMUST00000109496.1
ENSMUST00000109495.1
 Homer1





homer homolog 1 (Drosophila)





chrX_+_134404780 3.283 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr7_-_127449109 3.000 ENSMUST00000053392.4
 Zfp689
zinc finger protein 689

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 47.7 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.3 31.8 GO:0030032 lamellipodium assembly(GO:0030032)
2.9 8.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.1 7.3 GO:0060349 bone morphogenesis(GO:0060349)
0.5 6.5 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.6 6.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 5.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 5.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.5 5.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 4.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.9 4.6 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 3.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 3.3 GO:0050808 synapse organization(GO:0050808)
0.4 2.8 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.9 2.7 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.2 2.5 GO:0060536 cartilage morphogenesis(GO:0060536)
0.1 2.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 2.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 2.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 2.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 58.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 32.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
2.9 8.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 6.5 GO:0043679 axon terminus(GO:0043679)
0.1 6.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 5.3 GO:0055037 recycling endosome(GO:0055037)
0.5 5.1 GO:0043083 synaptic cleft(GO:0043083)
0.4 4.6 GO:0032584 growth cone membrane(GO:0032584)
0.2 3.0 GO:0030673 axolemma(GO:0030673)
0.2 2.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 2.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 1.7 GO:0010369 chromocenter(GO:0010369)
0.2 1.5 GO:0044308 axonal spine(GO:0044308)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.1 0.9 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.9 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.7 GO:0042587 glycogen granule(GO:0042587)
0.1 0.7 GO:0045298 tubulin complex(GO:0045298)
0.0 0.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 47.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 30.8 GO:0003779 actin binding(GO:0003779)
0.4 8.7 GO:0043274 phospholipase binding(GO:0043274)
0.1 7.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 6.6 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.9 6.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.7 5.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.8 4.6 GO:0005042 netrin receptor activity(GO:0005042)
0.7 3.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 2.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 2.5 GO:0005179 hormone activity(GO:0005179)
0.1 2.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.7 GO:0001948 glycoprotein binding(GO:0001948)
0.2 1.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 1.5 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 1.5 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.2 GO:0005125 cytokine activity(GO:0005125)