Motif ID: Onecut1_Cux2

Z-value: 2.035

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux2mm10_v2_chr5_-_122049822_122049882-0.724.0e-03Click!
Onecut1mm10_v2_chr9_+_74861888_74861921-0.165.9e-01Click!


Activity profile for motif Onecut1_Cux2.

activity profile for motif Onecut1_Cux2


Sorted Z-values histogram for motif Onecut1_Cux2

Sorted Z-values for motif Onecut1_Cux2



Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_64090241 25.122 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090265 22.599 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr14_+_68083853 8.663 ENSMUST00000022639.7
 Nefl
neurofilament, light polypeptide
chr19_-_57197435 8.603 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197377 8.573 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197496 8.367 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr1_-_158958367 7.310 ENSMUST00000159861.2
 Pappa2
pappalysin 2
chr19_-_57197556 6.647 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr9_-_50739365 6.463 ENSMUST00000117093.1
ENSMUST00000121634.1
 Dixdc1

DIX domain containing 1

chr7_+_75848338 6.341 ENSMUST00000092073.5
ENSMUST00000171155.2
 Klhl25

kelch-like 25

chrX_-_43274786 5.794 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr12_+_72441933 5.551 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr1_+_165302625 5.333 ENSMUST00000111450.1
 Gpr161
G protein-coupled receptor 161
chr7_+_35802593 5.150 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chrX_+_41401128 5.142 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr12_+_72441852 4.413 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr4_+_62965560 3.676 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
 Zfp618


zinc finger protein 618


chr13_+_93304940 3.442 ENSMUST00000109497.1
ENSMUST00000109498.1
ENSMUST00000060490.4
ENSMUST00000109492.1
ENSMUST00000109496.1
ENSMUST00000109495.1
 Homer1





homer homolog 1 (Drosophila)





chrX_+_134404780 3.283 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr7_-_127449109 3.000 ENSMUST00000053392.4
 Zfp689
zinc finger protein 689
chr8_-_31918203 2.981 ENSMUST00000073884.4
 Nrg1
neuregulin 1
chr7_-_127448993 2.895 ENSMUST00000106299.1
 Zfp689
zinc finger protein 689
chr13_+_93304799 2.755 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr19_-_37178011 2.667 ENSMUST00000133988.1
 Cpeb3
cytoplasmic polyadenylation element binding protein 3
chrX_+_134404543 2.652 ENSMUST00000113228.1
ENSMUST00000153424.1
 Drp2

dystrophin related protein 2

chr14_+_69029289 2.471 ENSMUST00000014957.8
 Stc1
stanniocalcin 1
chr18_-_72351009 2.362 ENSMUST00000073379.5
 Dcc
deleted in colorectal carcinoma
chr18_-_72351029 2.251 ENSMUST00000114943.3
 Dcc
deleted in colorectal carcinoma
chr11_+_120232921 2.170 ENSMUST00000122148.1
ENSMUST00000044985.7
 Bahcc1

BAH domain and coiled-coil containing 1

chr10_-_112928974 2.042 ENSMUST00000099276.2
 Atxn7l3b
ataxin 7-like 3B
chr6_+_4755327 1.980 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr8_+_20136455 1.961 ENSMUST00000179299.1
ENSMUST00000096485.4
 Gm21811

predicted gene, 21811

chr6_-_23248264 1.798 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_-_72986716 1.786 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr12_+_55598917 1.785 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr15_-_103215285 1.749 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5


chr2_-_7081207 1.734 ENSMUST00000114923.2
ENSMUST00000182706.1
 Celf2

CUGBP, Elav-like family member 2

chr15_+_92161343 1.733 ENSMUST00000068378.5
 Cntn1
contactin 1
chr4_-_97584612 1.628 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584605 1.540 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chrX_+_56609751 1.491 ENSMUST00000144068.1
 Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr1_+_191717834 1.453 ENSMUST00000110855.1
ENSMUST00000133076.1
 Lpgat1

lysophosphatidylglycerol acyltransferase 1

chr8_-_8660773 1.244 ENSMUST00000001319.7
 Efnb2
ephrin B2
chr9_-_114844090 1.243 ENSMUST00000047013.3
 Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr18_+_35965036 1.188 ENSMUST00000176873.1
ENSMUST00000177432.1
 Psd2

pleckstrin and Sec7 domain containing 2

chr9_+_54980880 1.102 ENSMUST00000093844.3
 Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr18_+_35965088 1.094 ENSMUST00000175734.1
 Psd2
pleckstrin and Sec7 domain containing 2
chr19_+_26750939 1.018 ENSMUST00000175953.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_+_8509477 0.968 ENSMUST00000029002.7
 Stmn2
stathmin-like 2
chr1_-_54438940 0.935 ENSMUST00000041638.6
 Gtf3c3
general transcription factor IIIC, polypeptide 3
chr2_+_163602294 0.929 ENSMUST00000171696.1
ENSMUST00000109408.3
 Ttpal

tocopherol (alpha) transfer protein-like

chr7_+_67647405 0.905 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr17_-_24479034 0.861 ENSMUST00000179163.1
ENSMUST00000070888.6
 Mlst8

MTOR associated protein, LST8 homolog (S. cerevisiae)

chr3_+_125404292 0.851 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr2_+_163602331 0.812 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr2_-_168767136 0.777 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr1_-_54194048 0.764 ENSMUST00000120904.1
 Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr8_-_79399513 0.736 ENSMUST00000066091.7
ENSMUST00000109885.1
ENSMUST00000066081.3
 Smad1


SMAD family member 1


chr3_+_125404072 0.690 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr2_-_25224653 0.669 ENSMUST00000043584.4
 Tubb4b
tubulin, beta 4B class IVB
chr5_+_149678224 0.624 ENSMUST00000100404.3
 B3galtl
beta 1,3-galactosyltransferase-like
chr2_-_7081256 0.616 ENSMUST00000183209.1
 Celf2
CUGBP, Elav-like family member 2
chr14_-_55092277 0.569 ENSMUST00000036328.8
 Zfhx2
zinc finger homeobox 2
chrX_-_51205990 0.550 ENSMUST00000114876.2
 Mbnl3
muscleblind-like 3 (Drosophila)
chr2_-_32451396 0.539 ENSMUST00000028160.8
ENSMUST00000113310.2
 Slc25a25

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

chr13_-_54688246 0.513 ENSMUST00000122935.1
ENSMUST00000128257.1
 Rnf44

ring finger protein 44

chr7_+_67655414 0.486 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr16_+_32431225 0.485 ENSMUST00000115140.1
 Pcyt1a
phosphate cytidylyltransferase 1, choline, alpha isoform
chr3_-_129755305 0.442 ENSMUST00000029653.2
 Egf
epidermal growth factor
chr4_+_5724304 0.440 ENSMUST00000108380.1
 Fam110b
family with sequence similarity 110, member B
chr3_+_68572245 0.384 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr12_-_80260091 0.381 ENSMUST00000167327.1
 Actn1
actinin, alpha 1
chr11_-_120624973 0.357 ENSMUST00000106183.2
ENSMUST00000080202.5
 Sirt7

sirtuin 7

chr2_+_130277157 0.309 ENSMUST00000028890.8
ENSMUST00000159373.1
 Nop56

NOP56 ribonucleoprotein

chr11_+_4902212 0.278 ENSMUST00000142543.1
 Thoc5
THO complex 5
chr3_+_94372794 0.273 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr16_+_32430895 0.230 ENSMUST00000115137.1
ENSMUST00000079791.4
 Pcyt1a

phosphate cytidylyltransferase 1, choline, alpha isoform

chr2_-_92392634 0.178 ENSMUST00000111279.2
 Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr17_+_55986494 0.077 ENSMUST00000011733.8
 Fsd1
fibronectin type 3 and SPRY domain-containing protein
chrX_-_102505359 0.047 ENSMUST00000087916.4
 Hdac8
histone deacetylase 8
chr2_-_168767029 0.047 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr7_-_116084635 0.044 ENSMUST00000111755.3
 Gm4353
predicted gene 4353
chr5_+_92683625 0.039 ENSMUST00000168878.1
 Shroom3
shroom family member 3
chr6_-_143100028 0.038 ENSMUST00000111758.2
ENSMUST00000171349.1
ENSMUST00000087485.4
 C2cd5


C2 calcium-dependent domain containing 5


chr1_-_51941261 0.026 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr7_+_45627482 0.001 ENSMUST00000057927.7
 Rasip1
Ras interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 47.7 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
2.9 8.7 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.9 4.6 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.9 2.7 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.6 6.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.5 6.5 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.5 5.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.4 2.8 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.3 31.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 1.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.3 1.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 2.5 GO:0060536 cartilage morphogenesis(GO:0060536)
0.2 0.7 GO:0006657 CDP-choline pathway(GO:0006657)
0.2 5.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 1.5 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.2 1.2 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.7 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 2.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 1.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 1.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 2.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.4 GO:0045896 regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.1 0.4 GO:0007262 STAT protein import into nucleus(GO:0007262) negative regulation of cholesterol efflux(GO:0090370) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 5.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 3.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 7.3 GO:0060349 bone morphogenesis(GO:0060349)
0.1 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 4.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 2.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.3 GO:0045650 negative regulation of macrophage differentiation(GO:0045650) negative regulation of DNA damage checkpoint(GO:2000002) regulation of stem cell division(GO:2000035)
0.0 0.3 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.0 0.5 GO:0002021 response to dietary excess(GO:0002021)
0.0 2.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.9 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.6 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 1.7 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 0.0 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 1.2 GO:0006935 chemotaxis(GO:0006935) taxis(GO:0042330)
0.0 0.4 GO:0001553 luteinization(GO:0001553)
0.0 3.3 GO:0050808 synapse organization(GO:0050808)
0.0 0.3 GO:0000154 rRNA modification(GO:0000154)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.5 5.1 GO:0043083 synaptic cleft(GO:0043083)
0.4 4.6 GO:0032584 growth cone membrane(GO:0032584)
0.3 32.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.5 GO:0044308 axonal spine(GO:0044308)
0.2 2.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.2 58.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 2.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 3.0 GO:0030673 axolemma(GO:0030673)
0.1 0.9 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 6.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.7 GO:0042587 glycogen granule(GO:0042587)
0.1 1.7 GO:0010369 chromocenter(GO:0010369)
0.1 0.9 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.7 GO:0045298 tubulin complex(GO:0045298)
0.1 0.2 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.0 5.3 GO:0055037 recycling endosome(GO:0055037)
0.0 6.5 GO:0043679 axon terminus(GO:0043679)
0.0 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.3 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.7 GO:0005637 nuclear inner membrane(GO:0005637)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.8 4.6 GO:0005042 netrin receptor activity(GO:0005042)
0.7 3.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.7 5.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.4 47.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.4 8.7 GO:0043274 phospholipase binding(GO:0043274)
0.2 2.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 1.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 1.5 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.2 6.6 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.2 0.7 GO:0070878 primary miRNA binding(GO:0070878)
0.1 0.7 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.1 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.1 0.4 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 7.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 30.8 GO:0003779 actin binding(GO:0003779)
0.0 1.5 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.0 2.5 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.7 GO:0001948 glycoprotein binding(GO:0001948)
0.0 1.2 GO:0005125 cytokine activity(GO:0005125)
0.0 1.8 GO:0003714 transcription corepressor activity(GO:0003714)