Motif ID: Pitx2_Otx2

Z-value: 1.830

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pitx2mm10_v2_chr3_+_129199960_129199975-0.497.4e-02Click!
Otx2mm10_v2_chr14_-_48667508_486676440.469.9e-02Click!


Activity profile for motif Pitx2_Otx2.

activity profile for motif Pitx2_Otx2


Sorted Z-values histogram for motif Pitx2_Otx2

Sorted Z-values for motif Pitx2_Otx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_99006056 3.308 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr17_-_35188427 2.383 ENSMUST00000097336.4
 Lst1
leukocyte specific transcript 1
chr13_-_66852017 1.768 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr3_+_95526777 1.761 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chrM_+_8600 1.724 ENSMUST00000082409.1
 mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr7_-_75782080 1.677 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr8_+_70131327 1.617 ENSMUST00000095273.5
 Nr2c2ap
nuclear receptor 2C2-associated protein
chr4_+_80910646 1.562 ENSMUST00000055922.3
 Lurap1l
leucine rich adaptor protein 1-like
chr7_-_118116128 1.470 ENSMUST00000128482.1
ENSMUST00000131840.1
 Rps15a

ribosomal protein S15A

chr11_+_101442298 1.455 ENSMUST00000077856.6
 Rpl27
ribosomal protein L27
chr9_-_114982739 1.448 ENSMUST00000053150.5
 Gm9846
predicted gene 9846
chrX_+_7909542 1.447 ENSMUST00000086274.2
 Gm10490
predicted gene 10490
chr10_-_80406811 1.445 ENSMUST00000020372.5
 Uqcr11
ubiquinol-cytochrome c reductase, complex III subunit XI
chr11_+_101448403 1.443 ENSMUST00000010502.6
 Ifi35
interferon-induced protein 35
chr19_+_12846773 1.437 ENSMUST00000164001.1
 Gm5244
predicted pseudogene 5244
chr19_+_3935186 1.424 ENSMUST00000162708.1
ENSMUST00000165711.1
 Unc93b1

unc-93 homolog B1 (C. elegans)

chr8_+_70673198 1.385 ENSMUST00000034311.8
 Lsm4
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr6_-_85933379 1.346 ENSMUST00000162660.1
 Nat8b
N-acetyltransferase 8B
chr4_+_41755210 1.326 ENSMUST00000108038.1
ENSMUST00000084695.4
 Galt

galactose-1-phosphate uridyl transferase

chr11_+_97029925 1.286 ENSMUST00000021249.4
 Scrn2
secernin 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 357 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 3.1 GO:0008360 regulation of cell shape(GO:0008360)
0.1 2.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 2.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 2.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 1.8 GO:2000598 regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.1 1.8 GO:0010447 response to acidic pH(GO:0010447)
0.0 1.8 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.3 1.7 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.5 1.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0 1.6 GO:0022904 respiratory electron transport chain(GO:0022904)
0.1 1.5 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.5 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.5 1.4 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.2 1.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 1.4 GO:0015816 glycine transport(GO:0015816)
0.1 1.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.4 1.3 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.3 1.3 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.2 1.3 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 7.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 6.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 3.8 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 2.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 2.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 2.1 GO:0005688 U6 snRNP(GO:0005688)
0.1 2.0 GO:0070469 respiratory chain(GO:0070469)
0.0 1.9 GO:0005581 collagen trimer(GO:0005581)
0.2 1.7 GO:0032009 early phagosome(GO:0032009)
0.0 1.6 GO:0005740 mitochondrial envelope(GO:0005740)
0.2 1.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 1.3 GO:0044316 cone cell pedicle(GO:0044316)
0.1 1.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 1.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.4 1.2 GO:0048269 methionine adenosyltransferase complex(GO:0048269)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 249 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 3.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 3.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 2.2 GO:0003774 motor activity(GO:0003774)
0.2 2.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 2.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 2.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.5 1.8 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 1.8 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.7 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.7 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 1.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 1.6 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 1.4 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 1.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 1.4 GO:0031491 nucleosome binding(GO:0031491)