Motif ID: Egr1

Z-value: 1.239


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_348612150.165.9e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_54156039 2.673 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr17_-_83631892 2.134 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr11_-_89302545 1.943 ENSMUST00000061728.3
 Nog
noggin
chr7_+_73740277 1.661 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr11_-_6065538 1.539 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_-_67922136 1.537 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chrY_+_897782 1.351 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chrX_-_160994665 1.307 ENSMUST00000087104.4
 Cdkl5
cyclin-dependent kinase-like 5
chr4_+_128883549 1.260 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr10_-_54075702 1.218 ENSMUST00000105470.1
 Man1a
mannosidase 1, alpha
chr5_+_137288273 1.198 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr19_-_50678642 1.186 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr10_-_54075730 1.130 ENSMUST00000105469.1
ENSMUST00000003843.8
 Man1a

mannosidase 1, alpha

chr5_+_137030275 1.115 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chr9_-_59750616 1.103 ENSMUST00000163586.1
ENSMUST00000177963.1
ENSMUST00000051039.4
 Senp8


SUMO/sentrin specific peptidase 8


chr6_-_60828889 1.052 ENSMUST00000114268.3
 Snca
synuclein, alpha
chr5_-_139130159 1.041 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr7_+_122671401 1.015 ENSMUST00000182095.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr7_+_122671378 1.010 ENSMUST00000182563.1
 Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr2_-_167188787 1.001 ENSMUST00000059826.8
 Kcnb1
potassium voltage gated channel, Shab-related subfamily, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 2.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 2.2 GO:0006491 N-glycan processing(GO:0006491)
0.1 2.1 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.7 2.0 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.5 1.9 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.2 1.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 1.6 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.3 1.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 1.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 1.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.4 1.2 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.2 1.2 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.2 1.2 GO:0019695 choline metabolic process(GO:0019695)
0.3 1.1 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) cellular response to copper ion(GO:0071280) regulation of peroxidase activity(GO:2000468)
0.1 1.1 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 1.1 GO:0043084 penile erection(GO:0043084)
0.2 1.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.2 1.0 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 1.0 GO:1901660 calcium ion export(GO:1901660)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0034704 calcium channel complex(GO:0034704)
0.0 2.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 2.3 GO:0032590 dendrite membrane(GO:0032590)
0.0 2.3 GO:0031526 brush border membrane(GO:0031526)
0.2 2.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.1 GO:0051233 spindle midzone(GO:0051233)
0.1 2.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.8 GO:0048786 presynaptic active zone(GO:0048786)
0.2 1.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 1.4 GO:0008091 spectrin(GO:0008091)
0.2 1.3 GO:0044294 dendritic growth cone(GO:0044294)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.2 GO:0097449 astrocyte projection(GO:0097449)
0.0 1.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 1.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.1 GO:0030667 secretory granule membrane(GO:0030667)
0.2 1.0 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.3 2.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 2.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 2.0 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 2.0 GO:0043274 phospholipase binding(GO:0043274)
0.2 1.8 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 1.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 1.6 GO:0035184 histone threonine kinase activity(GO:0035184)
0.3 1.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 1.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 1.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 1.4 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.3 1.2 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.1 1.2 GO:0032183 SUMO binding(GO:0032183)
0.0 1.2 GO:0019955 cytokine binding(GO:0019955)
0.2 1.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.2 1.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)