Motif ID: Tfap2a

Z-value: 1.084


Transcription factors associated with Tfap2a:

Gene SymbolEntrez IDGene Name
Tfap2a ENSMUSG00000021359.9 Tfap2a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2amm10_v2_chr13_-_40733768_407338360.602.2e-02Click!


Activity profile for motif Tfap2a.

activity profile for motif Tfap2a


Sorted Z-values histogram for motif Tfap2a

Sorted Z-values for motif Tfap2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_45114926 3.306 ENSMUST00000022967.5
 Kcnv1
potassium channel, subfamily V, member 1
chr12_-_67221221 2.982 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr10_+_100015817 2.874 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr9_+_26733728 2.046 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr13_-_98206151 1.787 ENSMUST00000109426.1
 Arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr14_-_65262391 1.647 ENSMUST00000131309.1
 Fzd3
frizzled homolog 3 (Drosophila)
chr7_+_121392266 1.634 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr17_-_87797994 1.497 ENSMUST00000055221.7
 Kcnk12
potassium channel, subfamily K, member 12
chr9_+_21184103 1.346 ENSMUST00000115458.2
 Pde4a
phosphodiesterase 4A, cAMP specific
chr14_-_102982630 1.322 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr9_+_34904913 1.267 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr2_+_172550991 1.259 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr12_-_45074112 1.236 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr6_+_56714891 1.186 ENSMUST00000031805.8
 Avl9
AVL9 homolog (S. cerevisiase)
chr9_+_26733845 1.118 ENSMUST00000115269.2
 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr10_-_86498836 1.092 ENSMUST00000120638.1
 Syn3
synapsin III
chr6_-_50456085 1.076 ENSMUST00000146341.1
ENSMUST00000071728.4
 Osbpl3

oxysterol binding protein-like 3

chr12_-_45074457 0.981 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chr1_-_52490736 0.979 ENSMUST00000170269.1
 Nab1
Ngfi-A binding protein 1
chr10_-_86498872 0.952 ENSMUST00000121789.1
 Syn3
synapsin III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.7 2.9 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.1 2.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.3 2.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 1.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 1.8 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.6 1.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 1.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.5 1.6 GO:0045976 negative regulation of mitotic cell cycle, embryonic(GO:0045976)
0.1 1.6 GO:0050832 defense response to fungus(GO:0050832)
0.1 1.5 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.5 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.0 1.4 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.3 1.3 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.3 1.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.2 GO:0033572 transferrin transport(GO:0033572)
0.2 1.1 GO:0060017 parathyroid gland development(GO:0060017)
0.1 1.0 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.3 0.9 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.3 0.9 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.2 GO:0000145 exocyst(GO:0000145)
0.0 1.9 GO:0055037 recycling endosome(GO:0055037)
0.0 1.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 1.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 1.6 GO:0032433 filopodium tip(GO:0032433)
0.1 1.5 GO:0043196 varicosity(GO:0043196)
0.1 1.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.4 GO:0005901 caveola(GO:0005901)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 1.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.0 GO:0005916 fascia adherens(GO:0005916)
0.0 1.0 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 0.8 GO:0072534 perineuronal net(GO:0072534)
0.0 0.8 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 5.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 3.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.5 2.9 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 2.6 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 2.5 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 1.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.7 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.2 1.6 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 1.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.3 GO:0030165 PDZ domain binding(GO:0030165)
0.2 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 1.1 GO:0046625 sphingolipid binding(GO:0046625)
0.0 1.1 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.1 GO:0015485 cholesterol binding(GO:0015485)
0.3 1.0 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 1.0 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)