Motif ID: Spic

Z-value: 1.930


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_886830250.166.0e-01Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136892867 13.409 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr1_-_171234290 10.881 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr4_-_136886187 10.632 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr3_+_95526777 7.214 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr4_+_130913120 6.272 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_130913264 6.176 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr1_-_170976112 6.050 ENSMUST00000027966.7
ENSMUST00000081103.5
ENSMUST00000159688.1
 Fcgr2b


Fc receptor, IgG, low affinity IIb


chr8_-_122432924 5.738 ENSMUST00000017604.8
 Cyba
cytochrome b-245, alpha polypeptide
chr12_+_112760652 4.804 ENSMUST00000063888.3
 Pld4
phospholipase D family, member 4
chr1_-_171059390 3.987 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr10_-_117282262 3.895 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr19_+_12460749 3.878 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1
chr19_-_11604828 3.480 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr12_+_77238093 3.148 ENSMUST00000177595.1
ENSMUST00000171770.2
 Fut8

fucosyltransferase 8

chr3_-_106790143 3.078 ENSMUST00000038845.8
 Cd53
CD53 antigen
chr15_+_103453782 3.059 ENSMUST00000047405.7
 Nckap1l
NCK associated protein 1 like
chr11_+_78324200 2.840 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr11_-_78984831 2.592 ENSMUST00000073001.4
ENSMUST00000108269.3
 Lgals9

lectin, galactose binding, soluble 9

chr16_+_91406235 2.591 ENSMUST00000023691.5
 Il10rb
interleukin 10 receptor, beta
chr12_-_4592927 2.569 ENSMUST00000170816.1
 Gm3625
predicted gene 3625

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 17.3 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
2.2 15.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.7 10.6 GO:0006958 complement activation, classical pathway(GO:0006958)
2.5 9.9 GO:1900426 positive regulation of defense response to bacterium(GO:1900426)
0.5 8.2 GO:0030574 collagen catabolic process(GO:0030574)
2.0 6.1 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.3 4.9 GO:0019835 cytolysis(GO:0019835)
0.0 4.1 GO:0006909 phagocytosis(GO:0006909)
0.3 3.9 GO:0010388 cullin deneddylation(GO:0010388)
1.0 3.1 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
1.0 3.1 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 3.1 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.3 2.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 2.6 GO:0007050 cell cycle arrest(GO:0007050)
0.5 2.5 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 2.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.8 2.4 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.6 2.3 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.6 2.3 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.1 2.3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 24.6 GO:0005581 collagen trimer(GO:0005581)
0.1 23.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 23.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.3 8.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
1.6 6.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 4.1 GO:0001772 immunological synapse(GO:0001772)
0.8 3.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 3.9 GO:0008180 COP9 signalosome(GO:0008180)
0.2 3.1 GO:0031209 SCAR complex(GO:0031209)
0.2 3.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.5 2.6 GO:0070820 tertiary granule(GO:0070820)
0.0 2.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.2 GO:0030673 axolemma(GO:0030673)
0.1 2.1 GO:0042555 MCM complex(GO:0042555)
0.1 1.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.8 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 1.5 GO:0005818 aster(GO:0005818)
0.2 1.5 GO:0008278 cohesin complex(GO:0008278)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 23.4 GO:0019864 IgG binding(GO:0019864)
2.0 8.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.3 7.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 7.0 GO:0017124 SH3 domain binding(GO:0017124)
1.0 5.8 GO:0016936 galactoside binding(GO:0016936)
0.5 4.4 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.2 3.6 GO:0042287 MHC protein binding(GO:0042287)
0.4 3.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.5 2.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 2.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 2.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.7 2.2 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.1 2.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 2.1 GO:0019209 kinase activator activity(GO:0019209)
0.0 2.0 GO:0003678 DNA helicase activity(GO:0003678)
0.0 2.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 1.9 GO:0005537 mannose binding(GO:0005537)
0.1 1.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 1.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)