Motif ID: Mbd2

Z-value: 1.278


Transcription factors associated with Mbd2:

Gene SymbolEntrez IDGene Name
Mbd2 ENSMUSG00000024513.10 Mbd2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mbd2mm10_v2_chr18_+_70568189_705683980.117.1e-01Click!


Activity profile for motif Mbd2.

activity profile for motif Mbd2


Sorted Z-values histogram for motif Mbd2

Sorted Z-values for motif Mbd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mbd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_108003414 7.618 ENSMUST00000109887.1
ENSMUST00000109891.2
 Bcl11b

B cell leukemia/lymphoma 11B

chr19_+_56722372 4.444 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr12_-_108003594 3.473 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr8_-_87959560 2.671 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr16_-_22163299 2.379 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr7_-_120982260 2.346 ENSMUST00000033169.8
 Cdr2
cerebellar degeneration-related 2
chr14_-_39472825 2.273 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr18_-_13972617 2.267 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr7_-_126082406 1.992 ENSMUST00000073935.5
 Gsg1l
GSG1-like
chr6_-_126740151 1.975 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr15_-_85581809 1.970 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr2_+_35622160 1.860 ENSMUST00000112992.2
 Dab2ip
disabled 2 interacting protein
chr9_+_26733845 1.814 ENSMUST00000115269.2
 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr2_+_35622010 1.754 ENSMUST00000091010.5
 Dab2ip
disabled 2 interacting protein
chr9_+_26733728 1.712 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr7_-_130266191 1.637 ENSMUST00000122054.1
 Fgfr2
fibroblast growth factor receptor 2
chr13_-_52981027 1.591 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr4_-_120747248 1.535 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr14_-_68124836 1.486 ENSMUST00000111089.1
ENSMUST00000022638.5
 Nefm

neurofilament, medium polypeptide

chr7_-_130266237 1.479 ENSMUST00000117872.1
ENSMUST00000120187.1
 Fgfr2

fibroblast growth factor receptor 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 11.1 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
1.5 4.4 GO:1900133 renin secretion into blood stream(GO:0002001) negative regulation of urine volume(GO:0035811) regulation of renin secretion into blood stream(GO:1900133)
0.7 3.6 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.2 3.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.0 3.1 GO:0035604 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.0 2.6 GO:0051028 mRNA transport(GO:0051028)
0.1 2.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.3 2.3 GO:0021830 interneuron migration from the subpallium to the cortex(GO:0021830)
0.1 2.2 GO:0007020 microtubule nucleation(GO:0007020)
0.7 2.0 GO:0072070 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) loop of Henle development(GO:0072070) metanephric loop of Henle development(GO:0072236)
0.6 1.9 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.5 1.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.4 1.6 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 1.6 GO:1901250 regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250)
0.1 1.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.5 1.5 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.4 1.5 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.2 1.4 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 1.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0005769 early endosome(GO:0005769)
0.9 3.6 GO:1990032 parallel fiber(GO:1990032)
0.0 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.4 GO:0031965 nuclear membrane(GO:0031965)
0.1 2.0 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.5 GO:0005883 neurofilament(GO:0005883)
0.1 1.4 GO:0071565 nBAF complex(GO:0071565)
0.1 1.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.1 1.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.9 GO:0097470 ribbon synapse(GO:0097470)
0.2 0.8 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.7 GO:0045298 tubulin complex(GO:0045298)
0.1 0.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.5 4.4 GO:0051379 epinephrine binding(GO:0051379)
0.5 3.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.6 3.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 3.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 3.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 2.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 2.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 2.4 GO:0045499 chemorepellent activity(GO:0045499)
0.5 2.0 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.6 1.9 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.4 1.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 1.7 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 1.5 GO:0015643 toxic substance binding(GO:0015643)
0.2 1.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.2 1.4 GO:0043559 insulin binding(GO:0043559)
0.0 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.2 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 1.0 GO:0051434 BH3 domain binding(GO:0051434)