Motif ID: Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.711

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec:

Gene SymbolEntrez IDGene Name
Arntl ENSMUSG00000055116.7 Arntl
Mitf ENSMUSG00000035158.9 Mitf
Mlx ENSMUSG00000017801.9 Mlx
Mlxipl ENSMUSG00000005373.7 Mlxipl
Tfe3 ENSMUSG00000000134.11 Tfe3
Tfec ENSMUSG00000029553.7 Tfec

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfe3mm10_v2_chrX_+_7763943_77640870.381.9e-01Click!
Mitfmm10_v2_chr6_+_97807014_97807067-0.352.2e-01Click!
Mlxiplmm10_v2_chr5_+_135106881_135106918-0.195.1e-01Click!
Arntlmm10_v2_chr7_+_113207465_113207595-0.185.4e-01Click!
Mlxmm10_v2_chr11_+_101087277_1010873230.097.6e-01Click!


Activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec.

activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec


Sorted Z-values histogram for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Sorted Z-values for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec



Network of associatons between targets according to the STRING database.



First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_108660772 2.723 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr6_+_108660616 2.232 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr2_-_71546745 1.968 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr8_+_13159135 1.656 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr9_+_21368014 1.591 ENSMUST00000067646.4
ENSMUST00000115414.1
 Ilf3

interleukin enhancer binding factor 3

chr10_-_128923439 1.462 ENSMUST00000153731.1
ENSMUST00000026405.3
 Bloc1s1

biogenesis of lysosome-related organelles complex-1, subunit 1

chr4_-_148038769 1.445 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr6_+_116338013 1.429 ENSMUST00000079012.6
ENSMUST00000101032.3
 March8

membrane-associated ring finger (C3HC4) 8

chr10_-_128923948 1.417 ENSMUST00000131271.1
 Bloc1s1
biogenesis of lysosome-related organelles complex-1, subunit 1
chr8_+_75093591 1.343 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr7_+_35802593 1.298 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr10_-_128922888 1.138 ENSMUST00000135161.1
 Rdh5
retinol dehydrogenase 5
chr13_-_92131494 1.131 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chrX_+_136224035 1.124 ENSMUST00000113116.2
 Tceal7
transcription elongation factor A (SII)-like 7
chr11_+_70000578 1.123 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr10_+_122678764 1.100 ENSMUST00000161487.1
ENSMUST00000067918.5
 Ppm1h

protein phosphatase 1H (PP2C domain containing)

chr3_+_137864573 1.043 ENSMUST00000174561.1
ENSMUST00000173790.1
 H2afz

H2A histone family, member Z

chr9_+_21411824 1.037 ENSMUST00000002902.6
 Qtrt1
queuine tRNA-ribosyltransferase 1
chr3_-_90052463 1.024 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
 Ubap2l


ubiquitin associated protein 2-like


chr19_-_4201591 1.020 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 379 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 2.8 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 2.6 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 2.4 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.5 2.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 2.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.7 2.0 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.4 1.7 GO:0010288 response to lead ion(GO:0010288)
0.0 1.7 GO:0007601 visual perception(GO:0007601)
0.5 1.6 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.2 1.6 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.1 1.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.3 1.5 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.2 1.5 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.5 1.4 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 1.4 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 1.4 GO:0048255 mRNA stabilization(GO:0048255)
0.4 1.3 GO:0015889 cobalamin transport(GO:0015889)
0.3 1.2 GO:1900426 positive regulation of defense response to bacterium(GO:1900426)
0.1 1.2 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 2.8 GO:0031083 BLOC-1 complex(GO:0031083)
0.3 1.9 GO:0001740 Barr body(GO:0001740)
0.2 1.8 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.5 1.6 GO:0044194 cytolytic granule(GO:0044194)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.0 1.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.2 GO:0031514 motile cilium(GO:0031514)
0.2 1.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 1.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.1 GO:0043203 axon hillock(GO:0043203)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.0 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.3 0.9 GO:0033186 CAF-1 complex(GO:0033186)
0.2 0.9 GO:0043020 NADPH oxidase complex(GO:0043020)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 257 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.0 GO:0043426 MRF binding(GO:0043426)
0.1 2.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 2.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.0 GO:0003924 GTPase activity(GO:0003924)
0.1 1.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.7 GO:0050699 WW domain binding(GO:0050699)
0.1 1.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 1.6 GO:0030332 cyclin binding(GO:0030332)
0.1 1.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.5 GO:0031404 chloride ion binding(GO:0031404)
0.5 1.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 1.4 GO:0031386 protein tag(GO:0031386)
0.3 1.3 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 1.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 1.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.3 1.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 1.1 GO:0031419 cobalamin binding(GO:0031419)
0.2 1.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)