Motif ID: Hlf

Z-value: 0.618


Transcription factors associated with Hlf:

Gene SymbolEntrez IDGene Name
Hlf ENSMUSG00000003949.10 Hlf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlfmm10_v2_chr11_-_90390895_90390926-0.352.2e-01Click!


Activity profile for motif Hlf.

activity profile for motif Hlf


Sorted Z-values histogram for motif Hlf

Sorted Z-values for motif Hlf



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_30413744 1.335 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr6_+_17463749 1.051 ENSMUST00000115443.1
 Met
met proto-oncogene
chr5_-_3473178 0.944 ENSMUST00000168422.1
 Gm17590
predicted gene, 17590
chr15_-_88978958 0.901 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr1_-_140183404 0.879 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr11_-_101785252 0.877 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr7_-_42578588 0.813 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr18_-_36726730 0.677 ENSMUST00000061829.6
 Cd14
CD14 antigen
chr10_-_31445921 0.641 ENSMUST00000000305.5
 Tpd52l1
tumor protein D52-like 1
chr8_-_92355764 0.616 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
 4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr1_-_140183283 0.588 ENSMUST00000111977.1
 Cfh
complement component factor h
chr9_+_94669876 0.587 ENSMUST00000033463.9
 Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr19_-_50678642 0.569 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr4_+_42735545 0.524 ENSMUST00000068158.3
 4930578G10Rik
RIKEN cDNA 4930578G10 gene
chr9_-_77347816 0.521 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr9_-_77347787 0.512 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr3_+_84952146 0.499 ENSMUST00000029727.7
 Fbxw7
F-box and WD-40 domain protein 7
chr9_-_21037775 0.496 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr7_+_18884679 0.493 ENSMUST00000032573.6
 Pglyrp1
peptidoglycan recognition protein 1
chr9_-_77347889 0.477 ENSMUST00000185039.1
 Mlip
muscular LMNA-interacting protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.5 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.3 1.3 GO:2001204 regulation of osteoclast development(GO:2001204)
0.2 1.1 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.1 1.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.9 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.1 0.9 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.2 0.7 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.1 0.6 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.6 GO:0043101 purine-containing compound salvage(GO:0043101)
0.2 0.5 GO:0008228 opsonization(GO:0008228) modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.1 0.5 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 0.5 GO:0098543 detection of bacterium(GO:0016045) negative regulation of natural killer cell activation(GO:0032815) detection of other organism(GO:0098543)
0.1 0.4 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.1 0.3 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.1 0.3 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.1 0.3 GO:0006867 asparagine transport(GO:0006867) glutamine transport(GO:0006868)
0.0 0.3 GO:0051043 regulation of membrane protein ectodomain proteolysis(GO:0051043) positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.3 GO:0015862 uridine transport(GO:0015862)
0.0 0.3 GO:0060012 synaptic transmission, glycinergic(GO:0060012)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 1.5 GO:0055037 recycling endosome(GO:0055037)
0.0 1.3 GO:0072562 blood microparticle(GO:0072562)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.1 0.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0031091 platelet alpha granule(GO:0031091)
0.0 0.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.5 GO:0001851 complement component C3b binding(GO:0001851)
0.3 1.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.9 GO:0051787 misfolded protein binding(GO:0051787)
0.2 0.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.2 0.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.6 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.2 0.5 GO:0042834 peptidoglycan binding(GO:0042834)
0.1 0.5 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.3 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 0.3 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 0.3 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.3 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 0.3 GO:0015186 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.3 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)