Motif ID: Nr6a1

Z-value: 0.621


Transcription factors associated with Nr6a1:

Gene SymbolEntrez IDGene Name
Nr6a1 ENSMUSG00000063972.7 Nr6a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_38926454-0.049.0e-01Click!


Activity profile for motif Nr6a1.

activity profile for motif Nr6a1


Sorted Z-values histogram for motif Nr6a1

Sorted Z-values for motif Nr6a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr6a1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_82505274 0.945 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr7_-_145283915 0.916 ENSMUST00000058022.4
 Tpcn2
two pore segment channel 2
chr4_-_82505749 0.804 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr17_+_72918298 0.772 ENSMUST00000024857.6
 Lbh
limb-bud and heart
chr7_+_30314810 0.763 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
 Syne4



spectrin repeat containing, nuclear envelope family member 4



chr4_-_45530330 0.717 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr9_-_96437434 0.584 ENSMUST00000070500.2
 BC043934
cDNA sequence BC043934
chr5_-_137611429 0.568 ENSMUST00000031731.7
 Pcolce
procollagen C-endopeptidase enhancer protein
chr6_+_42245907 0.562 ENSMUST00000031897.5
 Gstk1
glutathione S-transferase kappa 1
chr5_-_137611372 0.504 ENSMUST00000054564.6
 Pcolce
procollagen C-endopeptidase enhancer protein
chr16_+_17276337 0.461 ENSMUST00000159065.1
ENSMUST00000159494.1
ENSMUST00000159811.1
 Tmem191c


transmembrane protein 191C


chr14_+_12189943 0.436 ENSMUST00000119888.1
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr12_-_115790884 0.322 ENSMUST00000081809.5
 Ighv1-73
immunoglobulin heavy variable 1-73
chr2_+_25054396 0.316 ENSMUST00000102931.4
ENSMUST00000074422.7
ENSMUST00000132172.1
ENSMUST00000114388.1
ENSMUST00000114386.1
 Nsmf




NMDA receptor synaptonuclear signaling and neuronal migration factor




chr5_+_136987019 0.299 ENSMUST00000004968.4
 Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr2_+_172472512 0.286 ENSMUST00000029007.2
 Fam209
family with sequence similarity 209
chr5_-_5694024 0.270 ENSMUST00000115425.2
ENSMUST00000115427.1
ENSMUST00000115424.2
ENSMUST00000015797.4
 Steap2



six transmembrane epithelial antigen of prostate 2



chr4_-_125065603 0.266 ENSMUST00000036383.3
 Dnali1
dynein, axonemal, light intermediate polypeptide 1
chr16_+_17276291 0.260 ENSMUST00000164950.1
ENSMUST00000159242.1
 Tmem191c

transmembrane protein 191C

chr11_-_69822144 0.258 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr6_-_57535422 0.257 ENSMUST00000042766.3
 Ppm1k
protein phosphatase 1K (PP2C domain containing)
chr5_-_136986829 0.255 ENSMUST00000034953.7
ENSMUST00000085941.5
 Znhit1

zinc finger, HIT domain containing 1

chr4_-_123904826 0.239 ENSMUST00000181292.1
 Gm26606
predicted gene, 26606
chr9_+_98296556 0.229 ENSMUST00000035031.6
ENSMUST00000112935.1
 Nmnat3

nicotinamide nucleotide adenylyltransferase 3

chr2_+_177768044 0.219 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chr4_-_139131058 0.208 ENSMUST00000143971.1
 Minos1
mitochondrial inner membrane organizing system 1
chr18_-_77767752 0.189 ENSMUST00000048192.7
 Haus1
HAUS augmin-like complex, subunit 1
chr4_-_82505707 0.188 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr10_+_80855275 0.170 ENSMUST00000035597.8
 Sppl2b
signal peptide peptidase like 2B
chr10_-_43540945 0.164 ENSMUST00000147196.1
ENSMUST00000019932.3
 1700021F05Rik

RIKEN cDNA 1700021F05 gene

chr5_-_5694559 0.159 ENSMUST00000115426.2
 Steap2
six transmembrane epithelial antigen of prostate 2
chr5_-_108674753 0.146 ENSMUST00000119270.1
ENSMUST00000163328.1
ENSMUST00000136227.1
 Slc26a1


solute carrier family 26 (sulfate transporter), member 1


chr17_-_46645128 0.145 ENSMUST00000003642.6
 Klc4
kinesin light chain 4
chr10_+_128083273 0.144 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr10_-_80855187 0.142 ENSMUST00000035775.8
 Lsm7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_-_151428440 0.136 ENSMUST00000064771.5
 Swt1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr5_-_107972864 0.128 ENSMUST00000153172.1
 Fam69a
family with sequence similarity 69, member A
chr9_-_50603792 0.125 ENSMUST00000000175.4
 Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
chr6_+_135198034 0.117 ENSMUST00000130612.1
 8430419L09Rik
RIKEN cDNA 8430419L09 gene
chr15_-_98165560 0.113 ENSMUST00000123922.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr8_-_109693235 0.105 ENSMUST00000034164.4
 Ist1
increased sodium tolerance 1 homolog (yeast)
chr9_-_54647199 0.097 ENSMUST00000128163.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr19_-_5688149 0.096 ENSMUST00000068169.5
 Pcnxl3
pecanex-like 3 (Drosophila)
chr4_+_43632185 0.092 ENSMUST00000107874.2
 Npr2
natriuretic peptide receptor 2
chr17_+_33629078 0.091 ENSMUST00000166627.1
ENSMUST00000073570.5
ENSMUST00000170225.1
 Zfp414


zinc finger protein 414


chr2_+_157424255 0.088 ENSMUST00000029175.7
ENSMUST00000092576.4
 Src

Rous sarcoma oncogene

chr5_-_30073554 0.084 ENSMUST00000026846.6
 Tyms
thymidylate synthase
chr1_+_171329376 0.083 ENSMUST00000111299.1
ENSMUST00000064950.4
 Dedd

death effector domain-containing

chr9_+_50603892 0.075 ENSMUST00000044051.4
 Timm8b
translocase of inner mitochondrial membrane 8B
chr2_+_173737492 0.070 ENSMUST00000067530.4
 Vapb
vesicle-associated membrane protein, associated protein B and C
chr10_-_79916912 0.066 ENSMUST00000045628.7
ENSMUST00000171416.1
 R3hdm4

R3H domain containing 4

chr17_+_26123514 0.065 ENSMUST00000025014.8
 Mrpl28
mitochondrial ribosomal protein L28
chr4_+_123904907 0.064 ENSMUST00000106202.3
 Mycbp
c-myc binding protein
chr13_+_58281183 0.061 ENSMUST00000180882.1
ENSMUST00000180452.1
 Gm26555

predicted gene, 26555

chr13_-_24761440 0.059 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr15_-_98165613 0.058 ENSMUST00000143400.1
 Asb8
ankyrin repeat and SOCS box-containing 8
chr4_+_123904832 0.055 ENSMUST00000030400.7
 Mycbp
c-myc binding protein
chr11_+_120677226 0.049 ENSMUST00000129644.2
ENSMUST00000151160.1
 Aspscr1

alveolar soft part sarcoma chromosome region, candidate 1 (human)

chr11_+_6560183 0.043 ENSMUST00000109722.2
 Ccm2
cerebral cavernous malformation 2
chr7_-_105574324 0.026 ENSMUST00000081165.7
 Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr11_-_100770926 0.025 ENSMUST00000139341.1
ENSMUST00000017891.7
 Ghdc

GH3 domain containing

chr7_-_140881811 0.021 ENSMUST00000106048.3
ENSMUST00000147331.2
ENSMUST00000137710.1
 Sirt3


sirtuin 3


chr2_+_176431829 0.006 ENSMUST00000172025.1
 Gm14435
predicted gene 14435
chr8_+_75109528 0.005 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 0.4 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.1 0.8 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.8 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.2 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.1 GO:0009838 abscission(GO:0009838)
0.0 0.3 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.1 GO:0046078 dUMP metabolic process(GO:0046078)
0.0 0.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.3 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.9 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.3 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.1 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.0 0.3 GO:0006958 complement activation, classical pathway(GO:0006958)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.4 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 0.2 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 1.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.6 GO:0015035 glutathione peroxidase activity(GO:0004602) protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.8 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)