Motif ID: Nkx6-2

Z-value: 1.829


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.214.8e-01Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_58728887 9.688 ENSMUST00000048644.5
 Pnliprp1
pancreatic lipase related protein 1
chr6_-_144209471 9.656 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr6_-_144209558 9.335 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr19_-_14597983 8.989 ENSMUST00000052011.7
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_-_14598031 8.987 ENSMUST00000167776.2
 Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr3_+_103575275 7.234 ENSMUST00000090697.4
 Syt6
synaptotagmin VI
chr6_-_144209448 6.965 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr3_+_103575231 6.665 ENSMUST00000121834.1
 Syt6
synaptotagmin VI
chr4_-_97584612 6.155 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr16_-_22161450 6.139 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr4_-_97584605 5.910 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr15_-_13173607 4.657 ENSMUST00000036439.4
 Cdh6
cadherin 6
chr18_-_42899294 3.129 ENSMUST00000117687.1
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr17_-_48432723 3.112 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr1_+_66321708 2.117 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr10_+_37139558 1.877 ENSMUST00000062667.3
 5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr1_+_34005872 1.800 ENSMUST00000182296.1
 Dst
dystonin
chr4_-_83285141 1.673 ENSMUST00000150522.1
 Ttc39b
tetratricopeptide repeat domain 39B
chr6_+_125049903 1.592 ENSMUST00000112413.1
 Acrbp
proacrosin binding protein
chr4_-_21767173 1.589 ENSMUST00000029915.5
 Tstd3
thiosulfate sulfurtransferase (rhodanese)-like domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 26.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 14.7 GO:0016055 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
4.6 13.9 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 7.1 GO:0051028 mRNA transport(GO:0051028)
0.0 4.1 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 3.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 3.3 GO:0006869 lipid transport(GO:0006869)
0.2 3.2 GO:0048240 sperm capacitation(GO:0048240)
0.4 3.1 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.2 3.1 GO:0080111 DNA demethylation(GO:0080111)
0.1 1.8 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 1.6 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 1.4 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.1 1.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 1.3 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.4 1.2 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
0.2 1.2 GO:0019695 choline metabolic process(GO:0019695)
0.1 1.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.3 1.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268)
0.0 1.1 GO:0006342 chromatin silencing(GO:0006342)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 26.0 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.6 15.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.4 3.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 3.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.4 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.0 GO:0000786 nucleosome(GO:0000786)
0.0 1.6 GO:0043296 apical junction complex(GO:0043296)
0.1 1.4 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.2 GO:0097440 apical dendrite(GO:0097440)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.7 GO:0033391 chromatoid body(GO:0033391)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 0.7 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.5 GO:0071203 WASH complex(GO:0071203)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 25.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 18.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.3 13.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.9 9.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.4 6.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 4.9 GO:0005509 calcium ion binding(GO:0005509)
0.4 3.6 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 3.2 GO:0016504 peptidase activator activity(GO:0016504)
0.2 3.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 3.1 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.7 2.0 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 2.0 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.3 1.6 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 1.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 1.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 1.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.9 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)