Motif ID: Nkx6-2
Z-value: 1.829
Transcription factors associated with Nkx6-2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx6-2 | ENSMUSG00000041309.11 | Nkx6-2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx6-2 | mm10_v2_chr7_-_139582790_139582808 | -0.21 | 4.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.6 | 13.9 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
3.2 | 26.0 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
0.4 | 3.1 | GO:0034047 | regulation of protein phosphatase type 2A activity(GO:0034047) |
0.4 | 1.2 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
0.3 | 1.4 | GO:0050913 | sensory perception of bitter taste(GO:0050913) |
0.3 | 1.1 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268) |
0.2 | 0.7 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
0.2 | 1.2 | GO:0019695 | choline metabolic process(GO:0019695) |
0.2 | 3.2 | GO:0048240 | sperm capacitation(GO:0048240) |
0.2 | 3.1 | GO:0080111 | DNA demethylation(GO:0080111) |
0.1 | 0.9 | GO:1903056 | regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 0.4 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
0.1 | 0.7 | GO:0014719 | skeletal muscle satellite cell activation(GO:0014719) |
0.1 | 0.9 | GO:0007320 | insemination(GO:0007320) |
0.1 | 1.2 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
0.1 | 0.6 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
0.1 | 0.5 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of extracellular exosome assembly(GO:1903553) |
0.1 | 0.7 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.1 | 1.8 | GO:0008090 | retrograde axonal transport(GO:0008090) |
0.1 | 1.6 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
0.1 | 0.8 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.1 | 0.4 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
0.1 | 7.1 | GO:0051028 | mRNA transport(GO:0051028) |
0.1 | 0.2 | GO:0072356 | chromosome passenger complex localization to kinetochore(GO:0072356) |
0.1 | 1.3 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
0.1 | 0.2 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
0.0 | 4.1 | GO:0001578 | microtubule bundle formation(GO:0001578) |
0.0 | 3.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.5 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
0.0 | 0.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 0.5 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.0 | 0.2 | GO:0021631 | optic nerve morphogenesis(GO:0021631) |
0.0 | 0.1 | GO:1903887 | motile primary cilium assembly(GO:1903887) |
0.0 | 14.7 | GO:0016055 | Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738) |
0.0 | 0.3 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
0.0 | 0.2 | GO:1902965 | protein localization to early endosome(GO:1902946) regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
0.0 | 0.3 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.0 | 1.3 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
0.0 | 0.1 | GO:0033603 | positive regulation of dopamine secretion(GO:0033603) |
0.0 | 0.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
0.0 | 0.1 | GO:0008343 | adult feeding behavior(GO:0008343) |
0.0 | 1.1 | GO:0006342 | chromatin silencing(GO:0006342) |
0.0 | 0.2 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
0.0 | 3.3 | GO:0006869 | lipid transport(GO:0006869) |
0.0 | 0.7 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
0.0 | 0.2 | GO:0097352 | autophagosome maturation(GO:0097352) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 15.7 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.4 | 3.6 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.2 | 26.0 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
0.1 | 0.7 | GO:0033391 | chromatoid body(GO:0033391) |
0.1 | 1.4 | GO:0005652 | nuclear lamina(GO:0005652) |
0.1 | 1.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 0.5 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.0 | 0.5 | GO:0071203 | WASH complex(GO:0071203) |
0.0 | 3.2 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 0.7 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 1.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.0 | 1.2 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 2.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.5 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.0 | 0.3 | GO:0005642 | annulate lamellae(GO:0005642) |
0.0 | 2.0 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 0.7 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
0.0 | 0.3 | GO:0031011 | Ino80 complex(GO:0031011) |
0.0 | 0.1 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 0.1 | GO:0005883 | neurofilament(GO:0005883) |
0.0 | 0.2 | GO:0051286 | cell tip(GO:0051286) |
0.0 | 0.2 | GO:0046930 | pore complex(GO:0046930) |
0.0 | 1.6 | GO:0043296 | apical junction complex(GO:0043296) |
0.0 | 0.2 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
0.0 | 0.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.0 | 0.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.2 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 9.7 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.7 | 2.0 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
0.4 | 3.6 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.4 | 6.1 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
0.3 | 13.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.3 | 1.6 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
0.2 | 3.1 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
0.2 | 18.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.2 | 0.5 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
0.1 | 1.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.1 | 0.4 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
0.1 | 1.2 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.1 | 0.3 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
0.1 | 3.1 | GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814) |
0.1 | 3.2 | GO:0016504 | peptidase activator activity(GO:0016504) |
0.1 | 1.2 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.1 | 0.6 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.0 | 1.3 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.0 | 25.5 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
0.0 | 0.2 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.0 | 0.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.0 | 0.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.2 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
0.0 | 1.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.0 | 0.2 | GO:0015288 | porin activity(GO:0015288) |
0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 0.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 0.3 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.0 | 2.0 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
0.0 | 0.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.8 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
0.0 | 0.6 | GO:0004601 | peroxidase activity(GO:0004601) |
0.0 | 0.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 4.9 | GO:0005509 | calcium ion binding(GO:0005509) |