Motif ID: Cdx2

Z-value: 0.810


Transcription factors associated with Cdx2:

Gene SymbolEntrez IDGene Name
Cdx2 ENSMUSG00000029646.3 Cdx2



Activity profile for motif Cdx2.

activity profile for motif Cdx2


Sorted Z-values histogram for motif Cdx2

Sorted Z-values for motif Cdx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Cdx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_3270767 3.044 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr4_-_64046925 2.920 ENSMUST00000107377.3
Tnc
tenascin C
chr12_+_85473883 2.590 ENSMUST00000021674.6
Fos
FBJ osteosarcoma oncogene
chr1_-_186705980 2.497 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr4_+_144893127 2.230 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_+_118433797 2.168 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
Gm26871



predicted gene, 26871



chr6_+_17491216 1.902 ENSMUST00000080469.5
Met
met proto-oncogene
chr12_+_77238093 1.812 ENSMUST00000177595.1
ENSMUST00000171770.2
Fut8

fucosyltransferase 8

chr16_-_44016387 1.293 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C
chr6_+_38918969 1.262 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chrX_+_13632769 1.124 ENSMUST00000096492.3
Gpr34
G protein-coupled receptor 34
chr13_+_63282142 1.013 ENSMUST00000159152.1
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr4_-_24430838 0.903 ENSMUST00000183964.1
RP23-35K5.2
RP23-35K5.2
chr2_-_59948155 0.815 ENSMUST00000153136.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chrM_+_7759 0.743 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr11_-_79504078 0.718 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr2_+_4300462 0.596 ENSMUST00000175669.1
Frmd4a
FERM domain containing 4A
chr13_-_107890059 0.554 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr5_+_13399309 0.522 ENSMUST00000030714.7
ENSMUST00000141968.1
Sema3a

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

chr17_-_90088343 0.516 ENSMUST00000173917.1
Nrxn1
neurexin I
chr1_-_89933290 0.494 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr8_-_33843562 0.468 ENSMUST00000183062.1
Rbpms
RNA binding protein gene with multiple splicing
chr7_-_139582790 0.466 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr2_-_24048857 0.412 ENSMUST00000114497.1
Hnmt
histamine N-methyltransferase
chr8_-_105933832 0.395 ENSMUST00000034368.6
Ctrl
chymotrypsin-like
chr18_+_11839220 0.389 ENSMUST00000171109.1
ENSMUST00000046948.8
Cables1

CDK5 and Abl enzyme substrate 1

chr6_+_42286676 0.383 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr17_-_91092715 0.371 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr11_+_87663087 0.227 ENSMUST00000165679.1
Rnf43
ring finger protein 43
chr7_+_140763739 0.215 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr19_-_34879452 0.204 ENSMUST00000036584.5
Pank1
pantothenate kinase 1
chr19_+_8850785 0.200 ENSMUST00000096257.2
Lrrn4cl
LRRN4 C-terminal like
chr3_+_40540751 0.180 ENSMUST00000091186.3
Intu
inturned planar cell polarity effector homolog (Drosophila)
chr14_+_54686171 0.138 ENSMUST00000038539.6
1700123O20Rik
RIKEN cDNA 1700123O20 gene
chr3_-_10208569 0.132 ENSMUST00000029041.4
Fabp4
fatty acid binding protein 4, adipocyte
chr1_-_163289214 0.125 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr9_-_45936049 0.122 ENSMUST00000034590.2
Tagln
transgelin
chr18_+_37513652 0.092 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr15_-_50882806 0.062 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chrM_+_8600 0.057 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr6_-_122340525 0.051 ENSMUST00000112600.2
Phc1
polyhomeotic-like 1 (Drosophila)
chrX_+_96455359 0.040 ENSMUST00000033553.7
Heph
hephaestin
chr13_+_89540636 0.035 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr14_+_80000292 0.016 ENSMUST00000088735.3
Olfm4
olfactomedin 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.7 2.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.6 1.8 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.4 3.0 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 1.1 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.2 1.9 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.2 1.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 2.2 GO:0042572 retinol metabolic process(GO:0042572)
0.2 0.9 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 2.6 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.5 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 0.5 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1 0.5 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 1.0 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.7 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.2 GO:1903887 motile primary cilium assembly(GO:1903887)
0.0 0.5 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.6 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.2 GO:0019369 drug metabolic process(GO:0017144) arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0048664 neuron fate determination(GO:0048664)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.5 GO:0005604 basement membrane(GO:0005604)
0.0 1.9 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.6 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.9 GO:0042734 presynaptic membrane(GO:0042734)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.5 2.9 GO:0045545 syndecan binding(GO:0045545)
0.5 1.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 2.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 3.0 GO:0008430 selenium binding(GO:0008430)
0.2 1.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 2.6 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.9 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 1.8 GO:0046921 alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.0 1.3 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.5 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)