Motif ID: Zfhx3

Z-value: 0.983


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_1087146440.185.4e-01Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrM_+_7759 1.663 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chrM_-_14060 1.428 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chrM_+_2743 1.358 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr1_-_24612700 1.350 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr2_+_82053222 1.215 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chrM_+_9870 1.172 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr15_-_79285502 1.046 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr13_-_110280103 0.983 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr5_-_107875035 0.956 ENSMUST00000138111.1
ENSMUST00000112642.1
 Evi5

ecotropic viral integration site 5

chrM_+_7005 0.947 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chrM_+_14138 0.908 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr8_-_67818284 0.852 ENSMUST00000120071.1
 Psd3
pleckstrin and Sec7 domain containing 3
chr4_+_82065924 0.846 ENSMUST00000161588.1
 Gm5860
predicted gene 5860
chrM_+_9452 0.797 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr10_-_56228636 0.720 ENSMUST00000099739.3
 Tbc1d32
TBC1 domain family, member 32
chr12_+_71170589 0.714 ENSMUST00000129376.1
 2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr1_+_179961110 0.702 ENSMUST00000076687.5
ENSMUST00000097450.3
 Cdc42bpa

CDC42 binding protein kinase alpha

chr2_-_63184253 0.656 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr5_+_107497718 0.648 ENSMUST00000112671.2
 A830010M20Rik
RIKEN cDNA A830010M20 gene
chr9_+_95857597 0.614 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chr3_+_136670076 0.601 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr10_+_115384951 0.598 ENSMUST00000036044.8
 Zfc3h1
zinc finger, C3H1-type containing
chrX_-_111536325 0.594 ENSMUST00000156639.1
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chrX_-_143933204 0.592 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr8_-_9976294 0.583 ENSMUST00000095476.4
 Lig4
ligase IV, DNA, ATP-dependent
chr2_+_110597298 0.572 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr19_-_31765027 0.499 ENSMUST00000065067.6
 Prkg1
protein kinase, cGMP-dependent, type I
chr1_+_179960472 0.474 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr2_-_37647199 0.473 ENSMUST00000028279.3
 Strbp
spermatid perinuclear RNA binding protein
chr12_-_27160311 0.473 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
 Gm9866


predicted gene 9866


chr3_+_90537306 0.467 ENSMUST00000107335.1
 S100a16
S100 calcium binding protein A16
chr2_+_177768044 0.455 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chr9_-_22208546 0.445 ENSMUST00000167359.1
 1810064F22Rik
RIKEN cDNA 1810064F22 gene
chr4_+_13743424 0.435 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_172698046 0.392 ENSMUST00000038495.3
 Crp
C-reactive protein, pentraxin-related
chr1_-_158814469 0.392 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr1_+_74661794 0.377 ENSMUST00000129890.1
 Ttll4
tubulin tyrosine ligase-like family, member 4
chr8_+_47713266 0.370 ENSMUST00000180928.1
 E030037K01Rik
RIKEN cDNA E030037K01 gene
chr9_+_86485407 0.342 ENSMUST00000034987.8
 Dopey1
dopey family member 1
chr3_-_123385925 0.340 ENSMUST00000090371.7
ENSMUST00000174323.1
ENSMUST00000029759.9
 Mettl14


methyltransferase like 14


chr2_-_72986716 0.333 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr18_+_11633276 0.332 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr2_-_63184170 0.327 ENSMUST00000112452.1
 Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr5_+_107497762 0.300 ENSMUST00000152474.1
ENSMUST00000060553.7
 A830010M20Rik

RIKEN cDNA A830010M20 gene

chr3_+_28263205 0.275 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr4_+_109343029 0.263 ENSMUST00000030281.5
 Eps15
epidermal growth factor receptor pathway substrate 15
chr11_+_24078173 0.260 ENSMUST00000109514.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chrX_-_143933089 0.252 ENSMUST00000087313.3
 Dcx
doublecortin
chr2_+_121506748 0.250 ENSMUST00000099473.3
ENSMUST00000110602.2
 Wdr76

WD repeat domain 76

chr3_+_66985680 0.248 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr1_+_125676969 0.240 ENSMUST00000027581.6
 Gpr39
G protein-coupled receptor 39
chr2_-_140671462 0.207 ENSMUST00000110057.2
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr2_-_140671400 0.204 ENSMUST00000056760.3
 Flrt3
fibronectin leucine rich transmembrane protein 3
chr13_-_75943812 0.194 ENSMUST00000022078.5
ENSMUST00000109606.1
 Rhobtb3

Rho-related BTB domain containing 3

chr6_-_101377897 0.189 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr8_-_67818218 0.189 ENSMUST00000059374.4
 Psd3
pleckstrin and Sec7 domain containing 3
chr4_-_36056726 0.182 ENSMUST00000108124.3
 Lingo2
leucine rich repeat and Ig domain containing 2
chr17_+_36958571 0.174 ENSMUST00000040177.6
 Znrd1as
Znrd1 antisense
chr10_+_90576252 0.165 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
 Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr3_+_108571699 0.153 ENSMUST00000143054.1
 Taf13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr13_-_18382041 0.148 ENSMUST00000139064.2
ENSMUST00000175703.2
 Pou6f2

POU domain, class 6, transcription factor 2

chr14_+_64588112 0.133 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr3_+_76075583 0.128 ENSMUST00000160261.1
 Fstl5
follistatin-like 5
chr3_+_125404072 0.125 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr9_+_55326913 0.119 ENSMUST00000085754.3
ENSMUST00000034862.4
 AI118078

expressed sequence AI118078

chr10_-_17947997 0.115 ENSMUST00000037879.6
 Heca
headcase homolog (Drosophila)
chr7_+_55794146 0.100 ENSMUST00000032627.3
 Tubgcp5
tubulin, gamma complex associated protein 5
chr1_-_12991109 0.090 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr7_-_99980431 0.089 ENSMUST00000080817.4
 Rnf169
ring finger protein 169
chrX_+_163911401 0.085 ENSMUST00000140845.1
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr1_+_164275559 0.083 ENSMUST00000027867.6
 Ccdc181
coiled-coil domain containing 181
chr13_+_83732438 0.080 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr11_-_76027726 0.070 ENSMUST00000021207.6
 Fam101b
family with sequence similarity 101, member B
chr11_+_24078022 0.069 ENSMUST00000000881.6
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr3_+_66985647 0.059 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_90537242 0.053 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr19_+_10015016 0.050 ENSMUST00000137637.1
ENSMUST00000149967.1
 Rab3il1

RAB3A interacting protein (rabin3)-like 1

chr9_+_54980880 0.048 ENSMUST00000093844.3
 Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr8_-_66486494 0.047 ENSMUST00000026681.5
 Tma16
translation machinery associated 16 homolog (S. cerevisiae)
chr13_-_58354862 0.044 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr17_+_36958623 0.044 ENSMUST00000173814.1
 Znrd1as
Znrd1 antisense
chr8_+_33517306 0.040 ENSMUST00000124496.1
 Tex15
testis expressed gene 15
chr3_-_39359128 0.008 ENSMUST00000056409.2
 Gm9845
predicted pseudogene 9845

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.2 0.6 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.2 0.9 GO:0033762 response to glucagon(GO:0033762)
0.2 0.5 GO:2000224 testosterone biosynthetic process(GO:0061370) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.3 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 0.6 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.1 0.2 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.1 1.0 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.3 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.4 GO:0032929 negative regulation of macrophage derived foam cell differentiation(GO:0010745) negative regulation of superoxide anion generation(GO:0032929)
0.1 1.4 GO:0033194 response to hydroperoxide(GO:0033194)
0.1 1.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 1.2 GO:0007097 nuclear migration(GO:0007097)
0.0 0.6 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0080009 mRNA methylation(GO:0080009)
0.0 1.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.3 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.8 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.5 GO:0022900 electron transport chain(GO:0022900)
0.0 0.0 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 1.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.3 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.6 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.9 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 1.0 GO:0071439 clathrin complex(GO:0071439)
0.1 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.1 5.7 GO:0070469 respiratory chain(GO:0070469)
0.0 0.3 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.1 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.1 GO:0032432 actin filament bundle(GO:0032432)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.9 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.6 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 0.6 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.6 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.0 GO:0031489 myosin V binding(GO:0031489)
0.0 0.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.3 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 1.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.4 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0008758 thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.0 0.1 GO:0051011 microtubule minus-end binding(GO:0051011)