Motif ID: Hsf1

Z-value: 0.778


Transcription factors associated with Hsf1:

Gene SymbolEntrez IDGene Name
Hsf1 ENSMUSG00000022556.9 Hsf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf1mm10_v2_chr15_+_76477404_764774610.087.9e-01Click!


Activity profile for motif Hsf1.

activity profile for motif Hsf1


Sorted Z-values histogram for motif Hsf1

Sorted Z-values for motif Hsf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 107 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136892867 2.879 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr8_-_48555846 1.815 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr7_-_19310035 1.628 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr7_-_110862944 1.603 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr5_-_149636164 1.161 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chr14_-_48667508 0.859 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr9_+_22411515 0.826 ENSMUST00000058868.7
 9530077C05Rik
RIKEN cDNA 9530077C05 gene
chr4_+_152178126 0.802 ENSMUST00000075363.3
 Acot7
acyl-CoA thioesterase 7
chr5_-_149636331 0.770 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
 Hsph1



heat shock 105kDa/110kDa protein 1



chr5_+_30281377 0.701 ENSMUST00000101448.3
 Drc1
dynein regulatory complex subunit 1
chr10_+_59323296 0.613 ENSMUST00000009789.8
ENSMUST00000092512.4
ENSMUST00000105466.2
 P4ha1


procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide


chr6_-_136941887 0.610 ENSMUST00000111891.1
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr19_-_7039987 0.581 ENSMUST00000025918.7
 Stip1
stress-induced phosphoprotein 1
chr11_+_83662579 0.579 ENSMUST00000019074.3
 Ccl4
chemokine (C-C motif) ligand 4
chr10_-_80844025 0.572 ENSMUST00000053986.7
 Lingo3
leucine rich repeat and Ig domain containing 3
chr7_-_89941084 0.557 ENSMUST00000075010.4
ENSMUST00000153470.1
 l7Rn6

lethal, Chr 7, Rinchik 6

chr15_-_81399594 0.556 ENSMUST00000023039.8
 St13
suppression of tumorigenicity 13
chr6_-_128438673 0.528 ENSMUST00000032508.4
 Fkbp4
FK506 binding protein 4
chr18_-_36766198 0.523 ENSMUST00000061522.7
 Dnd1
dead end homolog 1 (zebrafish)
chr9_+_40801235 0.474 ENSMUST00000117870.1
ENSMUST00000117557.1
 Hspa8

heat shock protein 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.9 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.5 1.9 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.2 1.8 GO:0097264 self proteolysis(GO:0097264)
0.2 1.6 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 1.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 1.5 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.2 0.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 0.9 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.2 0.8 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.7 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.2 0.6 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.1 0.6 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.6 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.6 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.6 GO:0034605 cellular response to heat(GO:0034605)
0.2 0.5 GO:1903054 lysosomal membrane organization(GO:0097212) negative regulation of extracellular matrix organization(GO:1903054) positive regulation of protein folding(GO:1903334)
0.1 0.5 GO:0030576 Cajal body organization(GO:0030576)
0.1 0.5 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.5 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.5 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0005581 collagen trimer(GO:0005581)
0.1 1.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 0.6 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.5 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.5 GO:0015030 Cajal body(GO:0015030)
0.0 0.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 1.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.6 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 0.5 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.2 0.5 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.1 0.5 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.5 GO:0046790 virion binding(GO:0046790)
0.0 0.5 GO:0017091 AU-rich element binding(GO:0017091)
0.1 0.4 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.4 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.3 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.3 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.1 0.2 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.1 0.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)