Motif ID: Hoxb4

Z-value: 0.490


Transcription factors associated with Hoxb4:

Gene SymbolEntrez IDGene Name
Hoxb4 ENSMUSG00000038692.7 Hoxb4



Activity profile for motif Hoxb4.

activity profile for motif Hoxb4


Sorted Z-values histogram for motif Hoxb4

Sorted Z-values for motif Hoxb4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_116650674 1.276 ENSMUST00000067354.5
ENSMUST00000178241.1
 8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr2_-_84775420 1.099 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr8_-_105471481 1.015 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr13_+_94083490 0.950 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr2_-_84775388 0.910 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr12_+_58211772 0.847 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr18_-_15063560 0.815 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr10_-_92162753 0.664 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr1_+_10993452 0.586 ENSMUST00000027056.5
 Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr17_+_57279094 0.543 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
 Vav1


vav 1 oncogene


chr3_-_37125943 0.459 ENSMUST00000029275.5
 Il2
interleukin 2
chr7_+_28693032 0.393 ENSMUST00000151227.1
ENSMUST00000108281.1
 Fbxo27

F-box protein 27

chrX_-_49797700 0.296 ENSMUST00000033442.7
ENSMUST00000114891.1
 Igsf1

immunoglobulin superfamily, member 1

chr7_+_30232032 0.295 ENSMUST00000149654.1
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr17_+_86963279 0.281 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr1_-_45503282 0.262 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr10_-_59616667 0.262 ENSMUST00000020312.6
 Mcu
mitochondrial calcium uniporter
chr3_-_54714353 0.259 ENSMUST00000178832.1
 Gm21958
predicted gene, 21958
chr7_+_30231884 0.237 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr7_+_30232310 0.229 ENSMUST00000108193.1
ENSMUST00000108192.1
 Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr10_-_88605017 0.227 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr16_-_94370450 0.226 ENSMUST00000138514.1
 Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chrX_-_8193387 0.213 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr16_-_37384915 0.207 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
 Stxbp5l



syntaxin binding protein 5-like



chr4_+_43493345 0.196 ENSMUST00000030181.5
ENSMUST00000107922.2
 Ccdc107

coiled-coil domain containing 107

chr2_-_38714491 0.174 ENSMUST00000028084.4
 Nr5a1
nuclear receptor subfamily 5, group A, member 1
chr16_-_37384940 0.159 ENSMUST00000114781.1
ENSMUST00000114780.1
 Stxbp5l

syntaxin binding protein 5-like

chr15_-_50889691 0.158 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr3_-_39359128 0.154 ENSMUST00000056409.2
 Gm9845
predicted pseudogene 9845
chr10_-_89621253 0.148 ENSMUST00000020102.7
 Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr3_-_51277470 0.134 ENSMUST00000108053.2
ENSMUST00000108051.1
 Elf2

E74-like factor 2

chr17_+_43952999 0.100 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr6_+_142413441 0.099 ENSMUST00000088263.4
 B230216G23Rik
RIKEN cDNA B230216G23 gene
chr2_-_119156824 0.069 ENSMUST00000135419.1
ENSMUST00000129351.1
ENSMUST00000139519.1
ENSMUST00000094695.5
 Rmdn3



regulator of microtubule dynamics 3



chrX_+_166344692 0.066 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr8_+_83666827 0.037 ENSMUST00000019608.5
 Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr18_+_56562443 0.008 ENSMUST00000130163.1
ENSMUST00000132628.1
 Phax

phosphorylated adaptor for RNA export


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.3 0.8 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.1 0.5 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.2 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.0 0.8 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.5 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.3 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 1.0 GO:0001578 microtubule bundle formation(GO:0001578)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 2.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 2.0 GO:0001848 complement binding(GO:0001848)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.2 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 1.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0034711 inhibin binding(GO:0034711)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)