Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.569

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx1mm10_v2_chr5_-_24527276_245272760.371.9e-01Click!
Alx3mm10_v2_chr3_+_107595031_107595164-0.303.0e-01Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_11037968 2.202 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr13_-_102906046 1.775 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_14621805 1.578 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr5_-_62765618 1.569 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_134236483 1.420 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr3_-_116253467 1.388 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr1_+_104768510 1.346 ENSMUST00000062528.8
 Cdh20
cadherin 20
chr1_-_152625212 1.342 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr4_-_14621494 1.299 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 1.210 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr18_+_23415400 1.091 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr13_-_102905740 1.050 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr12_+_38780284 1.005 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr15_+_92597104 0.985 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr9_+_32116040 0.883 ENSMUST00000174641.1
 Arhgap32
Rho GTPase activating protein 32
chr5_-_62766153 0.803 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr12_+_38780817 0.777 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr5_-_137684665 0.748 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr4_-_155056784 0.734 ENSMUST00000131173.2
 Plch2
phospholipase C, eta 2
chr13_-_113663670 0.672 ENSMUST00000054650.4
 Hspb3
heat shock protein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.1 GO:0019532 oxalate transport(GO:0019532)
0.1 2.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 2.1 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 1.4 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.9 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.9 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.2 0.6 GO:0071336 lung growth(GO:0060437) positive regulation of fat cell proliferation(GO:0070346) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.1 0.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.5 GO:0016198 axon choice point recognition(GO:0016198)
0.1 0.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.5 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.5 GO:0001553 luteinization(GO:0001553)
0.0 0.5 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.4 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.0 GO:0031672 A band(GO:0031672)
0.0 0.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:0005915 zonula adherens(GO:0005915)
0.0 0.5 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.5 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.1 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.4 GO:0030673 axolemma(GO:0030673)
0.0 0.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.3 GO:0043205 fibril(GO:0043205)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 2.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 2.2 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)
0.2 1.4 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.7 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.7 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0 0.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 0.6 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.5 GO:0048185 activin binding(GO:0048185)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.5 GO:0042562 hormone binding(GO:0042562)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)