Motif ID: Hnf4a

Z-value: 0.458


Transcription factors associated with Hnf4a:

Gene SymbolEntrez IDGene Name
Hnf4a ENSMUSG00000017950.10 Hnf4a



Activity profile for motif Hnf4a.

activity profile for motif Hnf4a


Sorted Z-values histogram for motif Hnf4a

Sorted Z-values for motif Hnf4a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf4a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_41273977 1.171 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr9_-_77347816 0.640 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chrX_+_6415736 0.541 ENSMUST00000143641.3
 Shroom4
shroom family member 4
chr6_-_86765807 0.496 ENSMUST00000123732.1
 Anxa4
annexin A4
chr12_+_58211772 0.487 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr9_-_77347787 0.473 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr15_+_76797628 0.470 ENSMUST00000165535.2
 Gm17271
predicted gene, 17271
chr11_-_81968415 0.457 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr2_+_59160838 0.429 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
 Pkp4


plakophilin 4


chrX_-_162565514 0.429 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr3_+_107877227 0.407 ENSMUST00000037375.8
 Eps8l3
EPS8-like 3
chr6_+_54429603 0.407 ENSMUST00000132855.1
ENSMUST00000126637.1
 Wipf3

WAS/WASL interacting protein family, member 3

chr6_+_86195214 0.401 ENSMUST00000032066.9
 Tgfa
transforming growth factor alpha
chr7_+_112225856 0.393 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr4_+_152199805 0.359 ENSMUST00000105652.2
 Acot7
acyl-CoA thioesterase 7
chr4_+_126609818 0.346 ENSMUST00000097886.3
ENSMUST00000164362.1
 5730409E04Rik

RIKEN cDNA 5730409E04Rik gene

chr11_+_103774150 0.324 ENSMUST00000000127.5
 Wnt3
wingless-related MMTV integration site 3
chr11_+_104282371 0.320 ENSMUST00000106988.1
ENSMUST00000106989.1
 Mapt

microtubule-associated protein tau

chr17_+_55445375 0.308 ENSMUST00000133899.1
ENSMUST00000086878.3
 St6gal2

beta galactoside alpha 2,6 sialyltransferase 2

chr2_-_155582656 0.292 ENSMUST00000126322.1
 Gss
glutathione synthetase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 0.8 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.2 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.5 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.5 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.5 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.5 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 0.4 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.4 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.4 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.4 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.0 0.4 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.3 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.3 GO:0015879 carnitine transport(GO:0015879)
0.0 0.3 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.3 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 0.2 GO:0046104 thymidine metabolic process(GO:0046104)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 GO:0016460 myosin II complex(GO:0016460)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0045298 tubulin complex(GO:0045298)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 0.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.5 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.4 GO:0052872 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) tocotrienol omega-hydroxylase activity(GO:0052872) thalianol hydroxylase activity(GO:0080014)
0.0 0.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.3 GO:0005124 scavenger receptor binding(GO:0005124)
0.1 0.3 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.3 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.3 GO:0016594 glycine binding(GO:0016594)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0002054 nucleobase binding(GO:0002054)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)