Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 0.735

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrx2mm10_v2_chr2_+_30834972_308349720.234.4e-01Click!
Uncxmm10_v2_chr5_+_139543889_139543904-0.146.3e-01Click!
Shox2mm10_v2_chr3_-_66981279_669813180.009.9e-01Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_71528657 4.020 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr7_-_45103747 2.854 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr6_+_125552948 2.570 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr14_-_48665098 2.261 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr8_+_121116163 2.190 ENSMUST00000054691.6
 Foxc2
forkhead box C2
chr5_-_62766153 2.166 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_190170671 2.049 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr1_-_158356258 2.034 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr16_+_42907563 1.953 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chrM_+_7005 1.861 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chrM_+_2743 1.813 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr9_+_118478344 1.786 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_+_116067213 1.764 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr2_+_25372315 1.723 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr6_-_147264124 1.692 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr18_+_57468478 1.585 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr2_+_125136692 1.577 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr6_+_124304646 1.530 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr2_-_116067391 1.522 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr4_-_24430838 1.518 ENSMUST00000183964.1
 RP23-35K5.2
RP23-35K5.2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 4.0 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
1.2 3.5 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 3.4 GO:0022900 electron transport chain(GO:0022900)
1.0 3.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.0 2.6 GO:0030168 platelet activation(GO:0030168)
0.6 2.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 2.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 2.4 GO:0060074 synapse maturation(GO:0060074)
0.1 2.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.7 2.2 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278) regulation of vascular wound healing(GO:0061043) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.0 2.1 GO:0019882 antigen processing and presentation(GO:0019882)
0.2 2.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 1.8 GO:0033194 response to hydroperoxide(GO:0033194)
0.2 1.7 GO:0043129 surfactant homeostasis(GO:0043129)
0.3 1.5 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 1.5 GO:0006953 acute-phase response(GO:0006953)
0.1 1.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 1.3 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 1.3 GO:0030901 midbrain development(GO:0030901)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0070469 respiratory chain(GO:0070469)
0.0 4.5 GO:0005667 transcription factor complex(GO:0005667)
0.5 2.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.5 GO:0097440 apical dendrite(GO:0097440)
0.2 1.3 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 1.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.2 0.8 GO:0032280 symmetric synapse(GO:0032280)
0.2 0.8 GO:0031523 Myb complex(GO:0031523)
0.0 0.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.0 0.6 GO:0016459 myosin complex(GO:0016459)
0.1 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.3 GO:0044301 climbing fiber(GO:0044301)
0.1 0.3 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.1 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.3 GO:0070695 FHF complex(GO:0070695)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.0 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 4.3 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.4 3.5 GO:0050693 LBD domain binding(GO:0050693)
0.1 3.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 3.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 3.0 GO:0031490 chromatin DNA binding(GO:0031490)
1.0 2.9 GO:0019770 IgG receptor activity(GO:0019770)
0.0 2.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 2.6 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 2.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 1.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 1.5 GO:0031628 opioid receptor binding(GO:0031628)
0.1 1.5 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 1.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 1.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 1.3 GO:0001968 fibronectin binding(GO:0001968)